Zobrazeno 1 - 10
of 214
pro vyhledávání: '"Uridine transport"'
Autor:
Hamza A. A. Elati, Amber L. Goerner, Bruno Martorelli Di Genova, Lilach Sheiner, Harry P. de Koning
Publikováno v:
Frontiers in Cellular and Infection Microbiology, Vol 13 (2023)
Toxoplasmosis is a common protozoan infection that can have severe outcomes in the immunocompromised and during pregnancy, but treatment options are limited. Recently, nucleotide metabolism has received much attention as a target for new antiprotozoa
Externí odkaz:
https://doaj.org/article/bce7ae6bd9e84fbcb7717fc87cda9754
Akademický článek
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Autor:
Kimberley M. Zorn, Joseph L. Jilek, Xiaohong Zhang, Raymond K. Hau, Siennah R. Miller, Erin Q. Jennings, Sean Ekins, Daniel H. Foil, Nathan J. Cherrington, James J. Galligan, Stephen H. Wright
Publikováno v:
Mol Pharmacol
Equilibrative nucleoside transporters (ENTs) 1 and 2 facilitate nucleoside transport across the blood-testis barrier (BTB). Improving drug entry into the testes with drugs that use endogenous transport pathways may lead to more effective treatments f
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9787db3cc85c03d7e5045ec556121646
https://doi.org/10.1124/molpharm.120.000169
https://doi.org/10.1124/molpharm.120.000169
Autor:
Joseph L. Jilek, Raymond K. Hau, Nathan J. Cherrington, Siennah R. Miller, Mark Morales, Stephen H. Wright
Publikováno v:
Drug Metab Dispos
Equilibrative nucleoside transporters (ENTs) transport nucleosides across the blood-testis barrier (BTB). ENTs are of interest to study the disposition of nucleoside reverse-transcriptase inhibitors (NRTIs) in the human male genital tract because of
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7fc9a31cd6154302aa91efd017491b3c
https://europepmc.org/articles/PMC7318791/
https://europepmc.org/articles/PMC7318791/
Publikováno v:
Biochemical Journal. 475:3293-3309
Human equilibrative nucleoside transporter 1 (hENT1), the first identified member of the ENT family of integral membrane proteins, is the primary mechanism for cellular uptake of physiologic nucleosides and many antineoplastic and antiviral nucleosid
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::169d77ca49d5a9ba91989e58210e2aff
https://doi.org/10.1042/bcj20180543
https://doi.org/10.1042/bcj20180543
Akademický článek
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K zobrazení výsledku je třeba se přihlásit.
Autor:
George P.H. Leung, Shun Wan Chan, Chung Ming Tse, Philip Chiu Tsun Tang, Rachel Wai Sum Li, Simon Ming-Yuen Lee, Maggie Pui Man Hoi, Cui Yang, Yiu Wa Kwan
Publikováno v:
European Journal of Pharmacology. 791:544-551
Equilibrative nucleoside transporters (ENTs) play a crucial role in the transport of nucleoside and nucleoside analogues, which are important for nucleotide synthesis and chemotherapy. In addition, ENTs regulate extracellular adenosine levels in the
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::11fce8bd60acc348ea8691e94fa13642
https://doi.org/10.1016/j.ejphar.2016.07.002
https://doi.org/10.1016/j.ejphar.2016.07.002
Publikováno v:
Journal of Biological Chemistry. 291:18809-18817
Human nucleoside transporters (hNTs) mediate cellular influx of anticancer nucleoside drugs, including cytarabine, cladribine, and fludarabine. BCR-ABL tyrosine kinase inhibitors (TKIs) imatinib and dasatinib inhibit fludarabine and cytarabine uptake
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::e2bfc23e0a152203b184ce8f67fde99f
https://doi.org/10.1074/jbc.m116.741074
https://doi.org/10.1074/jbc.m116.741074
Autor:
Michelle Kuzma, Anderson J. Ryan, Carol E. Cass, Tara Scriver, Delores Mowles, Michael B. Sawyer, Vijaya L. Damaraju
Publikováno v:
Clinical Cancer Research. 20:176-186
Purpose: Combinations of tyrosine kinase inhibitors (TKI) with gemcitabine have been attempted with little added benefit to patients. We hypothesized that TKIs designed to bind to ATP-binding pockets of growth factor receptors also bind to transporte
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::61aff54f02549dec30791b53889f025d
https://doi.org/10.1158/1078-0432.ccr-13-2293
https://doi.org/10.1158/1078-0432.ccr-13-2293
Autor:
Ireneusz Nowak, Carol E. Cass, James D. Young, Edward Karpinski, Delores Mowles, Vijaya L. Damaraju, Kyla M. Smith, Morris J. Robins
Publikováno v:
Biochemical Pharmacology. 81:82-90
Human concentrative nucleoside transporters (hCNTs) mediate electrogenic secondary active transport of physiological nucleosides and nucleoside drugs into cells. Six fused-pyrimidine ribonucleosides and one 2'-deoxynucleoside were assessed for their
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::38b69eea87905d7c62b8afb2c8104779
https://doi.org/10.1016/j.bcp.2010.09.009
https://doi.org/10.1016/j.bcp.2010.09.009