Zobrazeno 1 - 10
of 209
pro vyhledávání: '"Uri, Seligsohn"'
Autor:
Nurit Rosenberg, Assaf A. Barg, Ivan Budnik, Sarina Levy-Mendelovich, Gili Kenet, Tami Livnat, Uri Seligsohn, Tamara Levy
Publikováno v:
Thrombosis and Haemostasis. 119:117-127
Introduction Glanzmann thrombasthenia (GT) is a rare bleeding disorder. The disease is caused by the lack or dysfunction of platelet membrane glycoprotein IIb/IIIa (integrin αIIbβ3) which is essential for platelet aggregation. Bleeding episodes are
Autor:
Marc A Rodger, Marisol T Betancourt, Peter Clark, Pelle G Lindqvist, Donna Dizon-Townson, Joanne Said, Uri Seligsohn, Marc Carrier, Ophira Salomon, Ian A Greer
Publikováno v:
PLoS Medicine, Vol 7, Iss 6, p e1000292 (2010)
BackgroundFactor V Leiden (FVL) and prothrombin gene mutation (PGM) are common inherited thrombophilias. Retrospective studies variably suggest a link between maternal FVL/PGM and placenta-mediated pregnancy complications including pregnancy loss, sm
Externí odkaz:
https://doaj.org/article/3427f3312eca46fc8ef1b913e66573b3
Autor:
Giorgia Zadra, Rosanna Asselta, Maria Luisa Tenchini, Giancarlo Castaman, Uri Seligsohn, Pier Mannuccio Mannucci, Stefano Duga
Publikováno v:
Haematologica, Vol 93, Iss 5 (2008)
Background Factor XI deficiency is a rare autosomal recessive coagulopathy, which is, however, common among Ashkenazi Jews, in whom the so-called type II (E117X) and type III (F283L) mutations account for 98% of alleles. In non-Jewish populations, a
Externí odkaz:
https://doaj.org/article/6a9f88f649334ac293993782ba1f585d
Autor:
Alkes L Price, Johannah Butler, Nick Patterson, Cristian Capelli, Vincenzo L Pascali, Francesca Scarnicci, Andres Ruiz-Linares, Leif Groop, Angelica A Saetta, Penelope Korkolopoulou, Uri Seligsohn, Alicja Waliszewska, Christine Schirmer, Kristin Ardlie, Alexis Ramos, James Nemesh, Lori Arbeitman, David B Goldstein, David Reich, Joel N Hirschhorn
Publikováno v:
PLoS Genetics, Vol 4, Iss 1, p e236 (2008)
European Americans are often treated as a homogeneous group, but in fact form a structured population due to historical immigration of diverse source populations. Discerning the ancestry of European Americans genotyped in association studies is impor
Externí odkaz:
https://doaj.org/article/57cfd5c3757043aebd911a8b61f1b22e
Autor:
Michal Zucker, Ariella Zivelin, Meytal Landau, Ophira Salomon, Gili Kenet, Frederic Bauduer, Michel Samama, Jacqueline Conard, Marie-Hélène Denninger, Abu-Samra Hani, Micheline Berruyer, Donald Feinstein, Uri Seligsohn
Publikováno v:
Haematologica, Vol 92, Iss 10 (2007)
Background and Objectives Factor XI (FXI) deficiency is a rare autosomal recessive disorder, the main manifestation of which is injury-related bleeding. The disorder is rare in most populations, but common among Jews in whom two mutations, E117X and
Externí odkaz:
https://doaj.org/article/47f3ce0a707347499acff32ff6842104
Autor:
Uri Seligsohn, Meital Nagar, Modi Misgav, Melanie Bokstad Horev, Maya Koren-Michowitz, Nurit Rosenberg, Hagit Hauschner
Publikováno v:
American journal of hematologyREFERENCES. 95(4)
Both JAK2V617F and calreticulin (CALR) mutated essential thrombocythemia (ET) patients have different clinical characteristics, with lower thrombosis risk in patients with CALR mutations. To elucidate the mechanism for this lower risk we studied plat
Autor:
Uri Seligsohn, Antoinette Blair, Matthew T. Rondina, Michal Zucker, Ronit Mor-Cohen, Colin K. Grissom, Robert A. Campbell, Samuel M. Brown
Publikováno v:
Journal of thrombosis and thrombolysis. 47(2)
BACKGROUND. Coagulation Factor XI (FXI) contributes to the pathobiology of sepsis-associated thrombosis and is a target for new therapeutics. Through cleavage of disulfide bonds, FXI becomes reduced (rFXI), accelerating intrinsic coagulation cascade
Autor:
Uri Seligsohn, Avigal Lask, Amihai Rottenstreich, Yosef Kalish, Ariella Zivelin, Lilliana Schliamser
Publikováno v:
Journal of Thrombosis and Thrombolysis. 42:261-266
Inherited afibrinogenemia and hypofibrinogenemia are rare bleeding disorders characterized by markedly reduced levels of fibrinogen in blood. Thrombotic complications in these disorders have been rarely described. We performed a multicenter retrospec
Publikováno v:
The Protein Journal. 33:474-483
The platelet integrin αIIbβ3 is widely accepted as a structural and a functional model of the broad integrin protein family. The four calcium-binding sites in the αIIb subunit contribute to biogenesis and stability of the protein. Mansour et al. (
Publikováno v:
Blood cells, moleculesdiseases. 69
Background The structure and function of platelet factor XI (FXI) protein and the presence of F11 mRNA in platelets are controversial. Although platelets are anucleated cells they contain spliceosome components and pre-mRNAs. Three platelet proteins