Understanding fungal and plant active urea transport systems: Keys from Aspergillus nidulans and beyond.

Autor: Ramón A; Sección Bioquímica, Departamento de Biología Celular y Molecular, Facultad de Ciencias, Universidad de la República, Iguá 4225 CP 11400, Montevideo, Uruguay. Electronic address: anaramon@fcien.edu.uy., Sanguinetti M; Sección Bioquímica, Departamento de Biología Celular y Molecular, Facultad de Ciencias, Universidad de la República, Iguá 4225 CP 11400, Montevideo, Uruguay. Electronic address: msanguinetti@fcien.edu.uy., Silva Santos LH; Biomolecular Simulations Group, Institut Pasteur de Montevideo, Mataojo 2020, CP, 11400, Montevideo, Uruguay. Electronic address: lsilva@pasteur.edu.uy., Amillis S; Department of Biology, National and Kapodistrian University of Athens, Panepistimioupolis, 15784, Athens, Greece; Department of Applied Genetics and Cell Biology, Institute of Microbial Genetics, University of Natural Resources and Life Sciences, Vienna, (BOKU), Campus Tulln, Konrad Lorenz Strasse 24, 3430, Tulln an der Donau, Austria. Electronic address: samillis@biol.uoa.gr.

Publikováno v: Biochemical and biophysical research communications [Biochem Biophys Res Commun] 2024 Nov 26; Vol. 735, pp. 150801. Date of Electronic Publication: 2024 Oct 13.

Impact of supplementation with L-citrulline/arginine after liver transplantation in individuals with Urea Cycle Disorders.

Autor: Posset R; Heidelberg University, Medical Faculty Heidelberg, and Center for Pediatric and Adolescent Medicine, Department I, Division of Pediatric Neurology and Metabolic Medicine, University Hospital Heidelberg, Im Neuenheimer Feld 430, 69120 Heidelberg, Germany. Electronic address: Roland.Posset@med.uni-heidelberg.de., Garbade SF; Heidelberg University, Medical Faculty Heidelberg, and Center for Pediatric and Adolescent Medicine, Department I, Division of Pediatric Neurology and Metabolic Medicine, University Hospital Heidelberg, Im Neuenheimer Feld 430, 69120 Heidelberg, Germany., Gleich F; Heidelberg University, Medical Faculty Heidelberg, and Center for Pediatric and Adolescent Medicine, Department I, Division of Pediatric Neurology and Metabolic Medicine, University Hospital Heidelberg, Im Neuenheimer Feld 430, 69120 Heidelberg, Germany., Nagamani SCS; Department of Molecular and Human Genetics, Baylor College of Medicine and Texas Children's Hospital, Houston, TX, USA., Gropman AL; Children's National Health System and The George Washington School of Medicine, Washington, DC, USA., Epp F; Heidelberg University, Medical Faculty Heidelberg, and Center for Pediatric and Adolescent Medicine, Department I, Division of Pediatric Neurology and Metabolic Medicine, University Hospital Heidelberg, Im Neuenheimer Feld 430, 69120 Heidelberg, Germany., Ramdhouni N; Heidelberg University, Medical Faculty Heidelberg, and Center for Pediatric and Adolescent Medicine, Department I, Division of Pediatric Neurology and Metabolic Medicine, University Hospital Heidelberg, Im Neuenheimer Feld 430, 69120 Heidelberg, Germany., Druck AC; Heidelberg University, Medical Faculty Heidelberg, and Center for Pediatric and Adolescent Medicine, Department I, Division of Pediatric Neurology and Metabolic Medicine, University Hospital Heidelberg, Im Neuenheimer Feld 430, 69120 Heidelberg, Germany., Hoffmann GF; Heidelberg University, Medical Faculty Heidelberg, and Center for Pediatric and Adolescent Medicine, Department I, Division of Pediatric Neurology and Metabolic Medicine, University Hospital Heidelberg, Im Neuenheimer Feld 430, 69120 Heidelberg, Germany., Kölker S; Heidelberg University, Medical Faculty Heidelberg, and Center for Pediatric and Adolescent Medicine, Department I, Division of Pediatric Neurology and Metabolic Medicine, University Hospital Heidelberg, Im Neuenheimer Feld 430, 69120 Heidelberg, Germany., Zielonka M; Heidelberg University, Medical Faculty Heidelberg, and Center for Pediatric and Adolescent Medicine, Department I, Division of Pediatric Neurology and Metabolic Medicine, University Hospital Heidelberg, Im Neuenheimer Feld 430, 69120 Heidelberg, Germany. Electronic address: Matthias.Zielonka@med.uni-heidelberg.de.

Publikováno v: Molecular genetics and metabolism [Mol Genet Metab] 2024 Mar; Vol. 141 (3), pp. 108112. Date of Electronic Publication: 2023 Dec 10.

Gene therapy for urea cycle defects: An update from historical perspectives to future prospects.

Autor: Duff C; Genetics and Genomic Medicine Department, Great Ormond Street Institute of Child Health, University College London, London, UK., Alexander IE; Gene Therapy Research Unit, Children's Medical Research Institute, Faculty of Medicine and Health, The University of Sydney and Sydney Children's Hospitals Network, Westmead, New South Wales, Australia.; Discipline of Child and Adolescent Health, The University of Sydney, Westmead, New South Wales, Australia., Baruteau J; Genetics and Genomic Medicine Department, Great Ormond Street Institute of Child Health, University College London, London, UK.; National Institute of Health Research Great Ormond Street Biomedical Research Centre, London, UK.; Metabolic Medicine Department, Great Ormond Street Hospital for Children NHS Foundation Trust, London, UK.

Publikováno v: Journal of inherited metabolic disease [J Inherit Metab Dis] 2024 Jan; Vol. 47 (1), pp. 50-62. Date of Electronic Publication: 2023 Apr 18.

Structural characterization of human urea transporters UT-A and UT-B and their inhibition.

Autor: Chi G; Structural Genomics Consortium, Nuffield Department of Medicine, University of Oxford, Roosevelt Drive, Oxford OX3 7DQ, UK.; Centre for Medicines Discovery, Nuffield Department of Medicine, University of Oxford, Nuffield Department of Medicine Research Building, Oxford OX3 7FZ, UK., Dietz L; Structural Genomics Consortium, Nuffield Department of Medicine, University of Oxford, Roosevelt Drive, Oxford OX3 7DQ, UK., Tang H; Department of Chemistry, University of Oxford, Oxford OX1 3TA, UK.; Kavli Institute for Nanoscience Discovery, University of Oxford, Oxford OX1 3QU, UK., Snee M; Structural Genomics Consortium, Nuffield Department of Medicine, University of Oxford, Roosevelt Drive, Oxford OX3 7DQ, UK., Scacioc A; Structural Genomics Consortium, Nuffield Department of Medicine, University of Oxford, Roosevelt Drive, Oxford OX3 7DQ, UK.; Centre for Medicines Discovery, Nuffield Department of Medicine, University of Oxford, Nuffield Department of Medicine Research Building, Oxford OX3 7FZ, UK., Wang D; Structural Genomics Consortium, Nuffield Department of Medicine, University of Oxford, Roosevelt Drive, Oxford OX3 7DQ, UK.; Centre for Medicines Discovery, Nuffield Department of Medicine, University of Oxford, Nuffield Department of Medicine Research Building, Oxford OX3 7FZ, UK., Mckinley G; Structural Genomics Consortium, Nuffield Department of Medicine, University of Oxford, Roosevelt Drive, Oxford OX3 7DQ, UK.; Centre for Medicines Discovery, Nuffield Department of Medicine, University of Oxford, Nuffield Department of Medicine Research Building, Oxford OX3 7FZ, UK., Mukhopadhyay SMM; Structural Genomics Consortium, Nuffield Department of Medicine, University of Oxford, Roosevelt Drive, Oxford OX3 7DQ, UK.; Centre for Medicines Discovery, Nuffield Department of Medicine, University of Oxford, Nuffield Department of Medicine Research Building, Oxford OX3 7FZ, UK., Pike ACW; Structural Genomics Consortium, Nuffield Department of Medicine, University of Oxford, Roosevelt Drive, Oxford OX3 7DQ, UK.; Centre for Medicines Discovery, Nuffield Department of Medicine, University of Oxford, Nuffield Department of Medicine Research Building, Oxford OX3 7FZ, UK., Chalk R; Structural Genomics Consortium, Nuffield Department of Medicine, University of Oxford, Roosevelt Drive, Oxford OX3 7DQ, UK.; Centre for Medicines Discovery, Nuffield Department of Medicine, University of Oxford, Nuffield Department of Medicine Research Building, Oxford OX3 7FZ, UK., Burgess-Brown NA; Structural Genomics Consortium, Nuffield Department of Medicine, University of Oxford, Roosevelt Drive, Oxford OX3 7DQ, UK.; Centre for Medicines Discovery, Nuffield Department of Medicine, University of Oxford, Nuffield Department of Medicine Research Building, Oxford OX3 7FZ, UK., Timmermans JP; Laboratory of Cell Biology and Histology (CBH) at Antwerp Centre for Advanced Microscopy (ACAM), Department of Veterinary Sciences, University of Antwerp, Groenenborgerlaan 171, 2020 Antwerp, Belgium., van Putte W; Laboratory of Cell Biology and Histology (CBH) at Antwerp Centre for Advanced Microscopy (ACAM), Department of Veterinary Sciences, University of Antwerp, Groenenborgerlaan 171, 2020 Antwerp, Belgium.; PUXANO, Ottergemsesteenweg Zuid 713, 9000 Gent, Belgium., Robinson CV; Department of Chemistry, University of Oxford, Oxford OX1 3TA, UK.; Kavli Institute for Nanoscience Discovery, University of Oxford, Oxford OX1 3QU, UK., Dürr KL; Structural Genomics Consortium, Nuffield Department of Medicine, University of Oxford, Roosevelt Drive, Oxford OX3 7DQ, UK.; Centre for Medicines Discovery, Nuffield Department of Medicine, University of Oxford, Nuffield Department of Medicine Research Building, Oxford OX3 7FZ, UK.

Publikováno v: Science advances [Sci Adv] 2023 Sep 29; Vol. 9 (39), pp. eadg8229. Date of Electronic Publication: 2023 Sep 29.

Time course of plasma urea and urinary urea excretion in patients with a prolonged ICU stay.

Autor: Zijlstra HW; Department of Critical Care, University Medical Center Groningen, Groningen, The Netherlands. h.w.zijlstra@umcg.nl.; Department of Critical Care, Martini Hospital, Groningen, The Netherlands. h.w.zijlstra@umcg.nl.; Department of Nephrology, University Medical Center Groningen, Groningen, The Netherlands. h.w.zijlstra@umcg.nl.; Department of Critical Care, University Medical Center Groningen, University of Groningen, Hanzeplein 1, 9700 RB, Groningen, The Netherlands. h.w.zijlstra@umcg.nl., Westland GJ; Department of Critical Care, University Medical Center Groningen, Groningen, The Netherlands., Volbeda M; Department of Critical Care, University Medical Center Groningen, Groningen, The Netherlands., van Meurs M; Department of Critical Care, University Medical Center Groningen, Groningen, The Netherlands., Pillay J; Department of Critical Care, University Medical Center Groningen, Groningen, The Netherlands., Franssen CFM; Department of Nephrology, University Medical Center Groningen, Groningen, The Netherlands., Stegeman CA; Department of Nephrology, University Medical Center Groningen, Groningen, The Netherlands., Nijsten MW; Department of Critical Care, University Medical Center Groningen, Groningen, The Netherlands.

Publikováno v: Scientific reports [Sci Rep] 2024 Oct 28; Vol. 14 (1), pp. 25779. Date of Electronic Publication: 2024 Oct 28.