Zobrazeno 1 - 10
of 539
pro vyhledávání: '"Urcelay Elena"'
Polymorphisms in the selenoprotein S gene: lack of association with autoimmune inflammatory diseases
Autor:
Díaz-Rubio Manuel, de la Calle Hermenegildo, Mendoza Juan, Lamas José, Márquez Ana, Varadé Jezabel, Santiago Jose, Martínez Alfonso, de la Concha Emilio G, Fernández-Gutiérrez Benjamín, Urcelay Elena
Publikováno v:
BMC Genomics, Vol 9, Iss 1, p 329 (2008)
Abstract Background Selenoprotein S (SelS) protects the functional integrity of the endoplasmic reticulum against the deleterious effects of metabolic stress. SEPS1/SelS polymorphisms have been involved in the increased release of pro-inflammatory cy
Externí odkaz:
https://doaj.org/article/17e281d741804d32bdfbd2da4b4fa250
Autor:
Urcelay Elena, de la Concha Emilio G, López-Nevot Miguel A, Gómez Luis M, Taxonera Carlos, Gómez-García María, Mendoza Juan, Oliver Javier, Núñez Concepción, Martínez Alfonso, Martín Javier
Publikováno v:
BMC Medical Genetics, Vol 8, Iss 1, p 75 (2007)
Abstract Background The etiology of Ulcerative Colitis (UC) and Crohn's Disease (CD), considered together as Inflammatory Bowel Diseases (IBD), involves environmental and genetic factors. Although some genes are already known, the genetics underlying
Externí odkaz:
https://doaj.org/article/b7ccac7b3dfc4fe683920659301b7a68
Autor:
Figueredo M Ángeles, Fernández-Arquero Miguel, de la Calle Hermenegildo, Martínez Alfonso, Santiago Jose, de la Concha Emilio G, Urcelay Elena
Publikováno v:
BMC Medical Genetics, Vol 8, Iss 1, p 54 (2007)
Abstract Background The protein tyrosine phosphatase N22 gene (PTPN22) encodes a lymphoid-specific phosphatase (LYP) which is an important downregulator of T cell activation. A PTPN22 polymorphism, C1858T, was found associated with type 1 diabetes (T
Externí odkaz:
https://doaj.org/article/a355dd65e5fe4a3c9523604dcd4862c9
Autor:
Figueredo M Ángeles, Fernández-Arquero Miguel, de la Calle Hermenegildo, Martínez Alfonso, Santiago Jose, de la Concha Emilio G, Urcelay Elena
Publikováno v:
BMC Medical Genetics, Vol 7, Iss 1, p 54 (2006)
Abstract Background Type 1 diabetes (T1D) is a chronic, autoimmune and multifactorial disease characterized by abnormal metabolism of carbohydrate and fat. Diminished carnitine plasma levels have been previously reported in T1D patients and carnitine
Externí odkaz:
https://doaj.org/article/72fd05a6d1b046e68da8adedadafa129
Autor:
Fontán Gumersindo, Ferreira Antonio, López-Mejías Raquel, Urcelay Elena, Fernández-Arquero Miguel, Ortiz Javier, de la Concha Emilio G, Martínez Alfonso
Publikováno v:
BMC Medical Genetics, Vol 7, Iss 1, p 56 (2006)
Abstract Background IgA deficiency (IgAD) is the most common primary immunodeficiency in Caucasians. Genetic and environmental factors are suspected to be involved in the development of the disease. Interleukin-10 (IL-10) is a cytokine with stimulato
Externí odkaz:
https://doaj.org/article/6300b711c2dc450f913b904c7a600645
Autor:
Fernández-Arquero Miguel, García-Rodríguez M Cruz, Martínez Alfonso, López-Mejías Raquel, Núñez Concepción, de la Concha Emilio G, Urcelay Elena
Publikováno v:
BMC Medical Genetics, Vol 7, Iss 1, p 25 (2006)
Abstract Background The 1858C/T SNP of the PTPN22 gene has been associated with many autoimmune diseases, suggesting the existence of an inflammatory process common to all of them. We studied the association of that polymorphism with immunoglobulin A
Externí odkaz:
https://doaj.org/article/2d88cf278dda4df2b2ddec8f55a8fefa
Autor:
Fernández-Arquero Miguel, Maluenda Carlos, Polanco Isabel, Varadé Jezabel, Alecsandru Diana, Núñez Concepción, de la Concha Emilio G, Urcelay Elena, Martínez Alfonso
Publikováno v:
BMC Medical Genetics, Vol 7, Iss 1, p 32 (2006)
Abstract Background Celiac disease (CD) is a chronic disorder characterized by a pathological inflammatory response after exposure to gluten in genetically susceptible individuals. The HLA complex accounts for less than half of the genetic component
Externí odkaz:
https://doaj.org/article/394114a93f084c3ca95e64804504e07f
Autor:
Fernández-Arquero Miguel, Arroyo Rafael, de las Heras Virginia, Mas Ana, Martínez Alfonso, de la Concha Emilio G, Urcelay Elena
Publikováno v:
BMC Neurology, Vol 5, Iss 1, p 19 (2005)
Abstract Background The etiology of multiple sclerosis (MS) is at present not fully elucidated, although it is considered to result from the interaction of environmental and genetic susceptibility factors. In this work we aimed at testing the Early B
Externí odkaz:
https://doaj.org/article/58eff414ca804d89abb3ed6e2097c5f0
Autor:
Ibarra José M, Méndez Julián, Martínez Alfonso, de la Calle Hermenegildo, Santiago José L, Urcelay Elena, Maluenda Carlos, Fernández-Arquero Miguel, de la Concha Emilio G
Publikováno v:
BMC Genomics, Vol 6, Iss 1, p 56 (2005)
Abstract Background The Major Histocompatibility Complex is the main genetic contributor to susceptibility to type 1 diabetes (T1D); genome-wide scans have consistently mapped increased predisposition to this region. The highest disease risk has been
Externí odkaz:
https://doaj.org/article/ed3ead23d1b04c4580e05f2268f8e7f0
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