Exposure of α-Synuclein Aggregates to Organotypic Slice Cultures Recapitulates Key Molecular Features of Parkinson's Disease

Autor: Serge Moudio, Fredrik Rodin, Nazira Jamal Albargothy, Urban Karlsson, Juan F. Reyes, Martin Hallbeck

Publikováno v: Frontiers in Neurology, Vol 13 (2022)

The accumulation of proteinaceous deposits comprised largely of the α-synuclein protein is one of the main hallmarks of Parkinson's disease (PD) and related synucleinopathies. Their progressive development coincides with site-specific phosphorylatio

Externí odkaz: https://doaj.org/article/9f67a8c12f044408a9929d0843d9ad2b

Synthetic resin acid derivatives selectively open the hK(V)7.2/7.3 channel and prevent epileptic seizures

Autor: Peter Konradsson, Michelle Nilsson, Malin Silverå Ejneby, Xiongyu Wu, Thomas A. Jepps, Urban Karlsson, Argel Estrada-Mondragón, Fredrik Elinder, Salomé Rognant, Melanie Schupp, Nina E. Ottosson

Publikováno v: Ottosson, N E, Ejneby, M S, Wu, X, Estrada-Mondragon, A, Nilsson, M, Karlsson, U, Schupp, M, Rognant, S, Jepps, T A, Konradsson, P & Elinder, F 2021, ' Synthetic resin acid derivatives selectively open the hK(V)7.2/7.3 channel and prevent epileptic seizures ', Epilepsia, vol. 62, no. 7, pp. 1744-1758 . https://doi.org/10.1111/epi.16932

Objective About one third of all patients with epilepsy have pharmacoresistant seizures. Thus there is a need for better pharmacological treatments. The human voltage-gated potassium (hK(V)) channel hK(V)7.2/7.3 is a validated antiseizure target for

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::43b80e815713c1101190996e21db2cc8
https://curis.ku.dk/ws/files/272246120/Synthetic_resin_acid_derivatives_selectively_open.pdf

Resin-Acid Derivatives Open the hKV7.2/7.3 Channel and have Antiepileptic Effects in a Zebrafish Larvae Model

Autor: Xiongyu Wu, Fredrik Elinder, Malin Silverå Ejneby, Melanie Schupp, Peter Konradsson, Nina E. Ottosson, Urban Karlsson, Michelle Nilsson

Publikováno v: Biophysical Journal. 118:264a-265a

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::de3c0c7c2e15671ace80579866e0a313
https://doi.org/10.1016/j.bpj.2019.11.1531

How to Properly Measure a Current-Voltage Relation?—Interpolation vs. Ramp Methods Applied to Studies of GABAA Receptors

Autor: Tushar Devanand Yelhekar, Staffan Johansson, Michael Druzin, Urban Karlsson, Erii Blomqvist

Publikováno v: Frontiers in Cellular Neuroscience
Frontiers in Cellular Neuroscience, Vol 10 (2016)

The relation between current and voltage, I-V relation, is central to functional analysis of membrane ion channels. A commonly used method, since the introduction of the voltage-clamp technique, to establish the I-V relation depends on the interpolat

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e39b34d540ce0c5ca0329608de51bd06
http://europepmc.org/articles/PMC4735409

Cl− concentration changes and desensitization of GABAA and glycine receptors

Autor: Staffan Johansson, Urban Karlsson, Michael Druzin

Publikováno v: The Journal of General Physiology

Desensitization of ligand-gated ion channels plays a critical role for the information transfer between neurons. The current view on γ-aminobutyric acid (GABA)(A) and glycine receptors includes significant rapid components of desensitization as well

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::564c4ac51412e32ab955c871cb7824f7
http://europepmc.org/articles/PMC3226965