Výsledky vyhledávání - "Urban Hoglund"

Identification of novel quinazoline derivatives as potent antiplasmodial agents

Autor: Johan Schultz, Dany Pechalrieu, Sergio Valente, Anne Bouchut, Tina S. Skinner-Adams, Giancarlo Fabrizi, Paola B. Arimondo, Urban Hoglund, Katherine T. Andrews, Roberta Mazzone, Sophia Lafitte, Antonello Mai, Alessia Lucidi, Christine Pierrot, Ming Jang Chua, Jamal Khalife, Dante Rotili

Publikováno v: European Journal of Medicinal Chemistry
European Journal of Medicinal Chemistry, Elsevier, 2019, 161, pp.277-291. ⟨10.1016/j.ejmech.2018.10.041⟩
European Journal of Medicinal Chemistry, 2019, 161, pp.277-291. ⟨10.1016/j.ejmech.2018.10.041⟩

International audience; Despite the recent reductions in the global burden of malaria, this disease remains a devastating cause of death in tropical and subtropical regions. As there is no broadly effective vaccine for malaria, prevention and treatme

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f4a86e82c36d3a424ed430d178a588e9
http://hdl.handle.net/20.500.12210/34198

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Inhibition of Histone Demethylases LSD1 and UTX Regulates ER alpha Signaling in Breast Cancer

Publikováno v: Cancers, 11
Cancers (Basel) 11 (2019). doi:10.3390/cancers11122027
info:cnr-pdr/source/autori:Benedetti R.; Dell'aversana C.; De Marchi T.; Rotili D.; Liu N.Q.; Novakovic B.; Boccella S.; Di Maro S.; Cosconati S.; Baldi A.; Nimeus E.; Schultz J.; Hoglund U.; Maione S.; Papulino C.; Chianese U.; Iovino F.; Federico A.; Mai A.; Stunnenberg H.G.; Nebbioso A.; Altucci L./titolo:Inhibition of histone demethylases LSD1 and UTX regulates ER? signaling in breast cancer/doi:10.3390%2Fcancers11122027/rivista:Cancers (Basel)/anno:2019/pagina_da:/pagina_a:/intervallo_pagine:/volume:11
Cancers, 11, 12
Cancers
Volume 11
Issue 12

In breast cancer, Lysine-specific demethylase-1 (LSD1) and other lysine demethylases (KDMs), such as Lysine-specific demethylase 6A also known as Ubiquitously transcribed tetratricopeptide repeat, X chromosome (UTX), are co-expressed and co-localize

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7dacb5c657324943b8f0c5cfb519a8d3
http://hdl.handle.net/2066/216059

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Akademický článek

A universal SARS‐CoV DNA vaccine inducing highly cross‐reactive neutralizing antibodies and T cells

Publikováno v: EMBO Molecular Medicine, Vol 14, Iss 10, Pp 1-11 (2022)

Abstract New variants in the SARS‐CoV‐2 pandemic are more contagious (Alpha/Delta), evade neutralizing antibodies (Beta), or both (Omicron). This poses a challenge in vaccine development according to WHO. We designed a more universal SARS‐CoV�

Externí odkaz: https://doaj.org/article/35ec9af66e3647f5894151746b9c3202

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Akademický článek

Macromolecular Viral Entry Inhibitors as Broad‐Spectrum First‐Line Antivirals with Activity against SARS‐CoV‐2

Publikováno v: Advanced Science, Vol 9, Iss 20, Pp n/a-n/a (2022)

Abstract Inhibitors of viral cell entry based on poly(styrene sulfonate) and its core–shell nanoformulations based on gold nanoparticles are investigated against a panel of viruses, including clinical isolates of SARS‐CoV‐2. Macromolecular inhi

Externí odkaz: https://doaj.org/article/efb36e92da2449a5bac3fba657c93ca6

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Akademický článek

Spike-Dependent Opsonization Indicates Both Dose-Dependent Inhibition of Phagocytosis and That Non-Neutralizing Antibodies Can Confer Protection to SARS-CoV-2

Publikováno v: Frontiers in Immunology, Vol 12 (2022)

Spike-specific antibodies are central to effective COVID19 immunity. Research efforts have focused on antibodies that neutralize the ACE2-Spike interaction but not on non-neutralizing antibodies. Antibody-dependent phagocytosis is an immune mechanism

Externí odkaz: https://doaj.org/article/f92905abfadc4d269db7f2ae1d052963

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Akademický článek

Enhanced Seroconversion to West Nile Virus Proteins in Mice by West Nile Kunjin Replicon Virus-like Particles Expressing Glycoproteins from Crimean–Congo Hemorrhagic Fever Virus

Autor: Pham-Tue-Hung Tran, Urban Höglund, Olivia Larsson, Sofia Appelberg, Ali Mirazimi, Magnus Johansson, Wessam Melik

Publikováno v: Pathogens, Vol 11, Iss 2, p 233 (2022)

Removal of genes coding for major parts of capsid (C), premembrane (prM), and envelope (E) proteins on the flavivirus genome aborts the production of infectious virus particles where the remaining genome forms a replicon that retains replicability in

Externí odkaz: https://doaj.org/article/4d896dff1f6c46319242a459b9fbf7aa

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Akademický článek

Development of a Multivalent Kunjin Virus Reporter Virus-Like Particle System Inducing Seroconversion for Ebola and West Nile Virus Proteins in Mice

Autor: Pham-Tue-Hung Tran, Naveed Asghar, Urban Höglund, Olivia Larsson, Lars Haag, Ali Mirazimi, Magnus Johansson, Wessam Melik

Publikováno v: Microorganisms, Vol 8, Iss 12, p 1890 (2020)

Kunjin virus (KUNV) is an attenuated strain of the severe neurotropic West Nile virus (WNV). The virus has a single-strand positive-sense RNA genome that encodes a polyprotein. Following gene expression, the polyprotein is cleaved into structural pro

Externí odkaz: https://doaj.org/article/377d46ced52b46f6931a998e21c821de

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