Zobrazeno 1 - 10
of 50
pro vyhledávání: '"Urban A Kiernan"'
Autor:
Eric E Niederkofler, David A Phillips, Bryan Krastins, Vathany Kulasingam, Urban A Kiernan, Kemmons A Tubbs, Scott M Peterman, Amol Prakash, Eleftherios P Diamandis, Mary F Lopez, Dobrin Nedelkov
Publikováno v:
PLoS ONE, Vol 8, Iss 11, p e81125 (2013)
Insulin-like growth factor 1 (IGF1) is an important biomarker of human growth disorders that is routinely analyzed in clinical laboratories. Mass spectrometry-based workflows offer a viable alternative to standard IGF1 immunoassays, which utilize var
Externí odkaz:
https://doaj.org/article/23c14967bec94eddb24220f0f7f531c7
Publikováno v:
PLoS ONE, Vol 6, Iss 3, p e17282 (2011)
Retinol Binding Protein 4 (RBP4) is an exciting new biomarker for the determination of insulin resistance and type 2 diabetes. It is known that circulating RBP4 resides in multiple variants which may provide enhanced clinical utility, but conventiona
Externí odkaz:
https://doaj.org/article/a7145298c68e4cbfb2df93f13ee8e232
Publikováno v:
Journal of Lipid Research, Vol 44, Iss 3, Pp 630-639 (2003)
Novel mass spectrometric immunoassays (MSIAs) for the isolation and structural characterization of plasma apolipoprotein A-I (apoA-I), apoA-II, and apoE have been developed. The assays combine selective isolation of apolipoprotein species via affinit
Externí odkaz:
https://doaj.org/article/e1ab40796ebd4c7e8035e1af99888607
Autor:
Anny Usheva, David A. Phillips, Hiroshi Maruyama, Ann Hammarstedt, Ulf Smith, Barbara B. Kahn, Bettina J. Kraus, Mark M. Yore, Tetsuya Hosooka, Julie Norseen, Shashi Kant, Roger J. Davis, Pratik Aryal, Urban A. Kiernan
Publikováno v:
Molecular and Cellular Biology. 32:2010-2019
Retinol-binding protein 4 (RBP4), the sole retinol transporter in blood, is secreted from adipocytes and liver. Serum RBP4 levels correlate highly with insulin resistance, other metabolic syndrome factors, and cardiovascular disease. Elevated serum R
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::19b9d8a81c26265613ab771103a7e41d
https://doi.org/10.1128/mcb.06193-11
https://doi.org/10.1128/mcb.06193-11
Autor:
Iratxe Eskurza, Qin Yang, Barbara B. Kahn, Urban A. Kiernan, Matthias Blüher, Timothy E. Graham, David A. Phillips
Publikováno v:
Endocrinology. 153:1519-1527
Serum retinol-binding protein 4 (RBP4) levels are increased in insulin-resistant humans and correlate with severity of insulin resistance in metabolic syndrome. Quantitative Western blotting (qWestern) has been the most accurate method for serum RBP4
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4f805e4e56079ad7513324f60a6166a0
https://doi.org/10.1210/en.2011-1750
https://doi.org/10.1210/en.2011-1750
Publikováno v:
PROTEOMICS - CLINICAL APPLICATIONS. 2:1019-1024
The urine proteome (urineome) has become an ideal biological fluid for biomarker study and detection due to its rich protein content as well as its ease and abundance in collection. Protein variation in human plasma has been linked to the presence of
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::30dde012c4bd3275f542d6740add5dc9
https://doi.org/10.1002/prca.200780118
https://doi.org/10.1002/prca.200780118
Autor:
Urban A Kiernan
Publikováno v:
Expert Review of Proteomics. 4:421-428
As proteomics attempts to enter clinical and diagnostic application, key issues surrounding the viability of various proteomics approaches must be evaluated. A major issue at the forefront of discussion is the ability to quantitate protein targets, i
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::36f1786212cd4669d3c0cf77067370ad
https://doi.org/10.1586/14789450.4.3.421
https://doi.org/10.1586/14789450.4.3.421
Autor:
Urban A. Kiernan, Gideon Koren, Katarzyna Suffecool, Janelle Foroutan, Priya Bapat, Kwasi Antwi, Barak Rosenn, Eric E. Niederkofler, Amanda Ribar
Publikováno v:
Diabetes care. 38(2)
Insulin detemir (IDet) is a relatively new long-acting insulin analog that offers improved absorption pharmacokinetics and slower tissue distribution due to high plasma protein binding (1). As IDet is increasingly used for treatment of insulin-requir
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9203e647553c8edf561d1d74a696fd66
https://pubmed.ncbi.nlm.nih.gov/25614695
https://pubmed.ncbi.nlm.nih.gov/25614695
Publikováno v:
Molecular & Cellular Proteomics. 5:1811-1818
This review outlines the concept of population proteomics and its implication in the discovery and validation of cancer-specific protein modulations. Population proteomics is an applied subdiscipline of proteomics engaging in the investigation of hum
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::f87348f5d05431a8b49e539ad4fc064c
https://doi.org/10.1074/mcp.r600006-mcp200
https://doi.org/10.1074/mcp.r600006-mcp200
Publikováno v:
Journal of Proteome Research. 5:2928-2934
Reported here is the development of a multiplexed mass spectrometric immunoassay (MSIA) for the detection of myocardial infarction (MI). The assay is the product of a study that systematically progresses from biomarker discoveryto identification and
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::f94723112e547fbf5af18ce9c977a79e
https://doi.org/10.1021/pr060062+
https://doi.org/10.1021/pr060062+