Zobrazeno 1 - 10
of 281
pro vyhledávání: '"Urban, Lendahl"'
Autor:
Eike-Benjamin Braune, Felix Geist, Xiaojia Tang, Krishna Kalari, Judy Boughey, Liewei Wang, Roberto A. Leon-Ferre, Antonino B. D’Assoro, James N. Ingle, Matthew P. Goetz, Julian Kreis, Kang Wang, Theodoros Foukakis, Anita Seshire, Dirk Wienke, Urban Lendahl
Publikováno v:
Breast Cancer Research, Vol 26, Iss 1, Pp 1-22 (2024)
Abstract Background Dysregulated Notch signalling contributes to breast cancer development and progression, but validated tools to measure the level of Notch signalling in breast cancer subtypes and in response to systemic therapy are largely lacking
Externí odkaz:
https://doaj.org/article/f8003a5a92c14e34b1fab373cd274d48
Autor:
Andrew Takchi, Minzhi Zhang, Mohammad Jalalirad, Roberto Leon Ferre, Royal Shrestha, Tufia Haddad, Jann Sarkaria, Ann Tuma, Jodi Carter, Hillman David, Karthik Giridhar, Liewei Wang, Carol Lange, Urban Lendahl, James Ingle, Matthew Goetz, Antonino Bonaventura D’Assoro
Publikováno v:
Frontiers in Oncology, Vol 14 (2024)
Triple negative breast cancer (TNBC) accounts for 15–20% of all breast cancers and mainly affects pre-menopausal and minority women. Because of the lack of ER, PR or HER2 expression in TNBC, there are limited options for tailored therapies. While T
Externí odkaz:
https://doaj.org/article/ef71d4b2bfbb4846b7a7d75ed4097563
Autor:
Francesca Del Gaudio, Dongli Liu, Maarja Andaloussi Mäe, Eike-Benjamin Braune, Emil M. Hansson, Qing-Dong Wang, Christer Betsholtz, Urban Lendahl
Publikováno v:
Scientific Reports, Vol 13, Iss 1, Pp 1-14 (2023)
Abstract The heart depends on a functional vasculature for oxygenation and transport of nutrients, and it is of interest to learn how primary impairment of the vasculature can indirectly affect cardiac function and heart morphology. Notch3-deficiency
Externí odkaz:
https://doaj.org/article/12b2410e4eda4271b1548e478b597290
Autor:
Daniel V Oliveira, Kirsten G Coupland, Wenchao Shao, Shaobo Jin, Francesca Del Gaudio, Sailan Wang, Rhys Fox, Julie W Rutten, Johan Sandin, Henrik Zetterberg, Johan Lundkvist, Saskia AJ Lesnik Oberstein, Urban Lendahl, Helena Karlström
Publikováno v:
EMBO Molecular Medicine, Vol 15, Iss 2, Pp 1-20 (2022)
Abstract Cerebral autosomal dominant arteriopathy with subcortical infarcts and leukoencephalopathy (CADASIL) is the most common monogenic form of familial small vessel disease; no preventive or curative therapy is available. CADASIL is caused by mut
Externí odkaz:
https://doaj.org/article/68d5b97efac9440abb6b6bcfdeb077ea
Autor:
Simona Hankeova, Noemi Van Hul, Jakub Laznovsky, Elisabeth Verboven, Katrin Mangold, Naomi Hensens, Csaba Adori, Elvira Verhoef, Tomas Zikmund, Feven Dawit, Michaela Kavkova, Jakub Salplachta, Marika Sjöqvist, Bengt R Johansson, Mohamed G Hassan, Linda Fredriksson, Karsten Baumgärtel, Vitezslav Bryja, Urban Lendahl, Andrew Jheon, Florian Alten, Kristina Teär Fahnehjelm, Björn Fischler, Jozef Kaiser, Emma R Andersson
Publikováno v:
EMBO Molecular Medicine, Vol 14, Iss 12, Pp 1-23 (2022)
Abstract Spontaneous bleeds are a leading cause of death in the pediatric JAG1‐related liver disease Alagille syndrome (ALGS). We asked whether there are sex differences in bleeding events in patients, whether Jag1Ndr/Ndr mice display bleeds or vas
Externí odkaz:
https://doaj.org/article/06eb0c1933c14c07a0211bd34884636e
Publikováno v:
Nature Communications, Vol 13, Iss 1, Pp 1-14 (2022)
In this review, the authors look at how recent progress in single-cell transcriptomics complement and enrich the classical, largely morphological, portraits of fibroblasts. The detailed molecular information now available provides new insights into f
Externí odkaz:
https://doaj.org/article/d3a88e121c1940e1938ead5ca617bbf0
Publikováno v:
BMC Biology, Vol 19, Iss 1, Pp 1-22 (2021)
Abstract Background Mitochondrial dynamics is the result of a dynamic balance between fusion and fission events, which are driven via a set of mitochondria-shaping proteins. These proteins are generally considered to be binary components of either th
Externí odkaz:
https://doaj.org/article/9bcf8f28200042278df7f9b9f3c52677
Publikováno v:
Open Biology, Vol 12, Iss 4 (2022)
Notch signalling is an evolutionarily highly conserved signalling mechanism governing differentiation and regulating homeostasis in many tissues. In this review, we discuss recent advances in our understanding of the roles that Notch signalling plays
Externí odkaz:
https://doaj.org/article/d4a5985401c448d09a2e8981d01bccf2
Autor:
Lars Muhl, Guillem Genové, Stefanos Leptidis, Jianping Liu, Liqun He, Giuseppe Mocci, Ying Sun, Sonja Gustafsson, Byambajav Buyandelger, Indira V. Chivukula, Åsa Segerstolpe, Elisabeth Raschperger, Emil M. Hansson, Johan L. M. Björkegren, Xiao-Rong Peng, Michael Vanlandewijck, Urban Lendahl, Christer Betsholtz
Publikováno v:
Nature Communications, Vol 11, Iss 1, Pp 1-18 (2020)
To define and distinguish fibroblasts from vascular mural cells have remained challenging. Here, using single-cell RNA sequencing and tissue imaging, the authors provide a molecular basis for cell type classification and reveal inter- and intra-organ
Externí odkaz:
https://doaj.org/article/5f2bea014f994236b4d2abd38b628f2e
Publikováno v:
EBioMedicine, Vol 74, Iss , Pp 103689- (2021)
Biliary Atresia is a devastating pediatric cholangiopathy affecting the bile ducts of the liver. In this review, we describe recent progress in the understanding of liver development with a focus on cholangiocyte differentiation and how use of techni
Externí odkaz:
https://doaj.org/article/668915f7c8c546829052a8cd35c683c9