Výsledky vyhledávání - "Urban, Košak"

Akademický článek

Treatment of canine cognitive dysfunction with novel butyrylcholinesterase inhibitor

Autor: Maja Zakošek Pipan, Sonja Prpar Mihevc, Malan Štrbenc, Urban Košak, Ilija German Ilić, Jurij Trontelj, Simon Žakelj, Stanislav Gobec, Darja Pavlin, Gregor Majdič

Publikováno v: Scientific Reports, Vol 11, Iss 1, Pp 1-10 (2021)

Abstract Canine cognitive dysfunction (CCD) is common in aged dogs and has many similarities with Alzheimer’s disease. Unfortunately, like Alzheimer’s disease, CCD cannot be cured. In the present study, we treated dogs with CCD with our newly dev

Externí odkaz: https://doaj.org/article/32c976e38cff4eb89133a4590bc3ef91

Zobrazit plný text záznamu

Akademický článek

A Simple and Effective Synthesis of 3- and 4-((Phenylcarbamoyl)oxy)benzoic Acids

Autor: Urban Košak, Stanislav Gobec

Publikováno v: Acta Chimica Slovenica, Vol 67, Iss 3, Pp 940-948 (2020)

Phenserine, posiphen, tolserine and cymserine and its derivatives are experimental Alzheimer’s disease drugs that contain a phenyl phenylcarbamate moiety that is responsible for their anti-Alzheimer activities. We have developed a simple (3 steps)

Externí odkaz: https://doaj.org/article/1b683dea22254bcf9a4e2596748928b1

Zobrazit plný text záznamu

Akademický článek

Development of potent reversible selective inhibitors of butyrylcholinesterase as fluorescent probes

Autor: Stane Pajk, Damijan Knez, Urban Košak, Maja Zorović, Xavier Brazzolotto, Nicolas Coquelle, Florian Nachon, Jacques-Philippe Colletier, Marko Živin, Jure Stojan, Stanislav Gobec

Publikováno v: Journal of Enzyme Inhibition and Medicinal Chemistry, Vol 35, Iss 1, Pp 498-505 (2020)

Brain butyrylcholinesterase (BChE) is an attractive target for drugs designed for the treatment of Alzheimer’s disease (AD) in its advanced stages. It also potentially represents a biomarker for progression of this disease. Based on the crystal str

Externí odkaz: https://doaj.org/article/dbf12d5fe8ba43da9d6b77ed1a105af9

Zobrazit plný text záznamu

Plný text ve formátu HTML

Repurposing of 8-Hydroxyquinoline-Based Butyrylcholinesterase and Cathepsin B Ligands as Potent Nonpeptidic Deoxyribonuclease I Inhibitors

Autor: Mihajlo Gajic, Damijan Knez, Izidor Sosič, Janez Mravljak, Anže Meden, Urban Košak, Luisa Leitzbach, Sven George, Bettina Hofmann, Aleksandra Zivkovic, Dieter Steinhilber, Holger Stark, Stanislav Gobec, Andrija Smelcerovic, Marko Anderluh

Publikováno v: ChemMedChem, str. 1-11, Vol. 17, iss. 5, 2022
COBISS-ID: 519053337

A library of 31 butyrylcholinesterase (BChE) and cathepsin B (CatB) inhibitors, was screened in vitro for inhibition of deoxyribonuclease I (DNase I). Compounds 22, 8 and 7 are among the most potent synthetic non-peptide DNase I inhibitors reported u

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2bf3a358ca06ba59bd1a7afc8192721b
https://pubmed.ncbi.nlm.nih.gov/34994078

Zobrazit plný text záznamu

Longitudinal Evaluation of a Novel BChE PET Tracer as An Early In Vivo Biomarker in the Brain of a Mouse Model for Alzheimer Disease

Publikováno v: Theranostics
Addi. Archivo Digital para la Docencia y la Investigación
instname
Addi: Archivo Digital para la Docencia y la Investigación
Universidad del País Vasco
Dipòsit Digital de la UB
Universidad de Barcelona

Purpose: The increase in butyrylcholinesterase (BChE) activity in the brain of Alzheimer disease (AD) patients and animal models of AD position this enzyme as a potential biomarker of the disease. However, the information on the ability of BChE to se

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::78aa3f6c23115abd785a53a122b059cb
http://hdl.handle.net/10810/51929

Zobrazit plný text záznamu

Synthesis and Initial Characterization of a Reversible, Selective \(^{18}\)F-Labeled Radiotracer for Human Butyrylcholinesterase

Autor: Philipp Spatz, Takahiro Higuchi, Urban Košak, Damijan Knez, Naoko Nose, Stanislav Gobec, Michael Decker, Xinyu Chen, Christian Gentzsch

Purpose A neuropathological hallmark of Alzheimer’s disease (AD) is the presence of amyloid-β (Aβ) plaques in the brain, which are observed in a significant number of cognitively normal, older adults as well. In AD, butyrylcholinesterase (BChE) b

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::31d7bd2b15e59a7a1bd36a74951179c5
https://opus.bibliothek.uni-wuerzburg.de/files/26987/Gentzsch_Molecular.pdf

Zobrazit plný text záznamu

Treatment of Canine Cognitive Dysfunction With Novel Butyrylcholinesterase Inhibitor

Autor: Sonja Prpar Mihevc, Darja Pavlin, Malan Štrbenc, Urban Košak, Ilija Ilić, Jurij Trontelj, Gregor Majdic, Maja Zakošek Pipan, Simon Žakelj, Stanislav Gobec

Publikováno v: Scientific reports, vol. 11, no. 18098, 2021.
Scientific reports, str. [1-10] : Ilustr., art. 18098, Vol. 11, 2021
COBISS-ID: 18727432
Scientific Reports, Vol 11, Iss 1, Pp 1-10 (2021)
Scientific Reports

Background: Canine cognitive dysfunction (CCD) is common in aged dogs and has many similarities with Alzheimer’s disease. Unfortunately, like Alzheimer’s disease, CCD cannot be cured. Methods: In the present study, we treated dogs with CCD with o

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::cba18d374e1d297444ebf4852a2f1e96
https://doi.org/10.21203/rs.3.rs-118291/v1

Zobrazit plný text záznamu

Synthesis and Initial Characterization of a Reversible, Selective

Autor: Christian, Gentzsch, Xinyu, Chen, Philipp, Spatz, Urban, Košak, Damijan, Knez, Naoko, Nose, Stanislav, Gobec, Takahiro, Higuchi, Michael, Decker

Publikováno v: Molecular Imaging and Biology

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::88a3da203952b27c71ba637a2ac3d6d6
https://pubmed.ncbi.nlm.nih.gov/33660167

Zobrazit plný text záznamu

Development of potent reversible selective inhibitors of butyrylcholinesterase as fluorescent probes

Autor: Xavier Brazzolotto, Florian Nachon, Marko Živin, Jure Stojan, Maja Zorović, Damijan Knez, Jacques-Philippe Colletier, Urban Košak, Stanislav Gobec, Stane Pajk, Nicolas Coquelle

Publikováno v: Journal of Enzyme Inhibition and Medicinal Chemistry
Journal of Enzyme Inhibition and Medicinal Chemistry, 2020, 35 (1), pp.498-505. ⟨10.1080/14756366.2019.1710502⟩
Journal of Enzyme Inhibition and Medicinal Chemistry, Informa Healthcare, 2020, 35 (1), pp.498-505. ⟨10.1080/14756366.2019.1710502⟩
Journal of enzyme inhibition and medicinal chemistry, vol. 35, no. 1, pp. 498-505, 2020.
Journal of Enzyme Inhibition and Medicinal Chemistry, Vol 35, Iss 1, Pp 498-505 (2020)

International audience; Brain butyrylcholinesterase (BChE) is an attractive target for drugs designed for the treatment of Alzheimer’s disease (AD) in its advanced stages. It also potentially represents a biomarker for progression of this disease.

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::346bbfead7d353e2e74735bc335c4593
https://hal.science/hal-03014299/file/Pajk2020.pdf

Zobrazit plný text záznamu

N-alkylpiperidine carbamates as potential anti-Alzheimer’s agents

Autor: Nika Strašek, Abida Zahirović, Damijan Knez, Florian Nachon, Urban Košak, Xavier Brazzolotto, Simon Žakelj, Janko Kos, Anja Pišlar, Marko Jukič, Stanislav Gobec

Publikováno v: European Journal of Medicinal Chemistry. 197:112282

Compounds capable of interacting with single or multiple targets involved in Alzheimer’s disease (AD) pathogenesis are potential anti-Alzheimer’s agents. In our aim to develop new anti-Alzheimer’s agents, a series of 36 new N-alkylpiperidine ca

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::12fee10e02a975ea027fb35f6a132662
https://doi.org/10.1016/j.ejmech.2020.112282

Zobrazit plný text záznamu

Vyhledávací nástroje:

Upřesnit hledání