Early postnatal behavioral, cellular, and molecular changes in models of Huntington disease are reversible by HDAC inhibition.

Autor: Siebzehnrübl FA; McKnight Brain Institute, Department of Neurosurgery, University of Florida, Gainesville, FL 32611.; European Cancer Stem Cell Research Institute, Cardiff University School of Biosciences, Cardiff CF10 3AX, United Kingdom., Raber KA; Department of Experimental Therapy, Friedrich-Alexander-University, 91054 Erlangen, Germany., Urbach YK; Department of Experimental Therapy, Friedrich-Alexander-University, 91054 Erlangen, Germany., Schulze-Krebs A; Department of Experimental Therapy, Friedrich-Alexander-University, 91054 Erlangen, Germany., Canneva F; Department of Experimental Therapy, Friedrich-Alexander-University, 91054 Erlangen, Germany., Moceri S; Department of Experimental Therapy, Friedrich-Alexander-University, 91054 Erlangen, Germany., Habermeyer J; Department of Experimental Therapy, Friedrich-Alexander-University, 91054 Erlangen, Germany., Achoui D; McKnight Brain Institute, Department of Neurosurgery, University of Florida, Gainesville, FL 32611., Gupta B; European Cancer Stem Cell Research Institute, Cardiff University School of Biosciences, Cardiff CF10 3AX, United Kingdom., Steindler DA; McKnight Brain Institute, Department of Neurosurgery, University of Florida, Gainesville, FL 32611.; Neuroscience and Aging Laboratory, Jean Mayer USDA Human Nutrition Research Center on Aging, Tufts University, Medford, MA 02155., Stephan M; Clinic of Psychosomatic and Psychotherapy, Medical School Hannover, 30625 Hannover, Germany., Nguyen HP; Institute of Medical Genetics and Applied Genomics, Center for Rare Diseases, University of Tübingen, 72074 Tübingen, Germany., Bonin M; Institute of Medical Genetics and Applied Genomics, Center for Rare Diseases, University of Tübingen, 72074 Tübingen, Germany., Riess O; Institute of Medical Genetics and Applied Genomics, Center for Rare Diseases, University of Tübingen, 72074 Tübingen, Germany., Bauer A; Institute of Neuroscience and Medicine, Forschungszentrum Jülich, 52425 Jülich, Germany., Aigner L; Institute of Molecular Regenerative Medicine, Paracelsus Medical University, 5020 Salzburg, Austria., Couillard-Despres S; Institute of Experimental Neuroregeneration, Spinal Cord Injury and Tissue Regeneration Center Salzburg, Paracelsus Medical University, 5020 Salzburg, Austria., Paucar MA; Section of Translational Neuropharmacology, Department of Physiology and Pharmacology, Karolinska Institute, 171 77 Solna, Sweden., Svenningsson P; Section of Translational Neuropharmacology, Department of Physiology and Pharmacology, Karolinska Institute, 171 77 Solna, Sweden., Osmand A; Department of Biochemistry and Cellular and Molecular Biology, University of Tennessee, Knoxville, TN 37996., Andreew A; Institute for Human Genetics, Charité-Universitätsmedizin, 13353 Berlin, Germany., Zabel C; Institute for Human Genetics, Charité-Universitätsmedizin, 13353 Berlin, Germany., Weiss A; Neuroscience Discovery, Novartis Pharma AG, 4056 Basel, Switzerland., Kuhn R; Neuroscience Discovery, Novartis Pharma AG, 4056 Basel, Switzerland., Moussaoui S; Neuroscience Discovery, Novartis Pharma AG, 4056 Basel, Switzerland., Blockx I; Bio-Imaging Laboratory, University of Antwerp, 2000 Antwerp, Belgium., Van der Linden A; Bio-Imaging Laboratory, University of Antwerp, 2000 Antwerp, Belgium., Cheong RY; Translational Neuroendocrine Research Unit, Department of Experimental Medical Science, Lund University, 221 84 Lund, Sweden., Roybon L; Stem Cell Laboratory for CNS Disease Modeling, Department of Experimental Medical Science, Lund University, 221 84 Lund, Sweden., Petersén Å; Translational Neuroendocrine Research Unit, Department of Experimental Medical Science, Lund University, 221 84 Lund, Sweden., von Hörsten S; Department of Experimental Therapy, Friedrich-Alexander-University, 91054 Erlangen, Germany; stephan.v.hoersten@fau.de.

Publikováno v: Proceedings of the National Academy of Sciences of the United States of America [Proc Natl Acad Sci U S A] 2018 Sep 11; Vol. 115 (37), pp. E8765-E8774. Date of Electronic Publication: 2018 Aug 27.

Automated phenotyping and advanced data mining exemplified in rats transgenic for Huntington's disease.

Autor: Urbach YK; Experimental Therapy, Preclinical Experimental Center, Universitätsklinikum Erlangen, 91054 Erlangen, Germany., Raber KA; Experimental Therapy, Preclinical Experimental Center, Universitätsklinikum Erlangen, 91054 Erlangen, Germany., Canneva F; Experimental Therapy, Preclinical Experimental Center, Universitätsklinikum Erlangen, 91054 Erlangen, Germany., Plank AC; Experimental Therapy, Preclinical Experimental Center, Universitätsklinikum Erlangen, 91054 Erlangen, Germany., Andreasson T; NeuroSearch Sweden AB, Arvid Wallgrens Backe 20, 41346 Gothenburg, Sweden., Ponten H; NeuroSearch Sweden AB, Arvid Wallgrens Backe 20, 41346 Gothenburg, Sweden., Kullingsjö J; NeuroSearch Sweden AB, Arvid Wallgrens Backe 20, 41346 Gothenburg, Sweden., Nguyen HP; Department of Medical Genetics, University of Tübingen, 72076 Tübingen, Germany., Riess O; Department of Medical Genetics, University of Tübingen, 72076 Tübingen, Germany., von Hörsten S; Experimental Therapy, Preclinical Experimental Center, Universitätsklinikum Erlangen, 91054 Erlangen, Germany. Electronic address: Stephan.v.Hoersten@uk-erlangen.dede.

Publikováno v: Journal of neuroscience methods [J Neurosci Methods] 2014 Aug 30; Vol. 234, pp. 38-53. Date of Electronic Publication: 2014 Jul 11.

Neurobehavioral tests in rat models of degenerative brain diseases.

Autor: Urbach YK; Franz-Penzoldt-Center, Experimental Therapy, Friedrich-Alexander-University of Erlangen-Nürnberg, Erlangen, Germany., Bode FJ, Nguyen HP, Riess O, von Hörsten S

Publikováno v: Methods in molecular biology (Clifton, N.J.) [Methods Mol Biol] 2010; Vol. 597, pp. 333-56.