Zobrazeno 1 - 10
of 411
pro vyhledávání: '"Urate transport"'
Publikováno v:
Arthritis Research & Therapy, Vol 21, Iss 1, Pp 1-10 (2019)
Abstract Background ABCG2 is a high-capacity urate transporter that plays a crucial role in renal urate overload and extra-renal urate underexcretion. Previous studies have suggested an association between hyperuricemia and gout susceptibility relati
Externí odkaz:
https://doaj.org/article/eabeafd0922d4141b2c23c10f17ccffb
Autor:
Jiří Vávra, Andrea Mančíková, Kateřina Pavelcová, Lenka Hasíková, Jana Bohatá, Blanka Stibůrková
Publikováno v:
Cells, Vol 11, Iss 7, p 1063 (2022)
The OAT1 (SLC22A6) and OAT3 (SLC22A8) urate transporters are located on the basolateral membrane of the proximal renal tubules, where they ensure the uptake of uric acid from the urine back into the body. In a cohort of 150 Czech patients with primar
Externí odkaz:
https://doaj.org/article/51fca690f87947968790cbab6e029aaa
Akademický článek
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Autor:
Tubular Handling of Uric Acid and Factors Influencing Its Renal Excretion: A Short Review, Gabriele Pricoco, Damiano Cantone, Elisa Marino, Francesca Bruno
Publikováno v:
European Medical Journal Nephrology, Vol 4, Iss 1, Pp 92-97 (2016)
In this review, the authors briefly examine the most recent evidence concerning the role of several proteins involved in tubular urate transport. They also analyse the influence of extracellular volume, electrolyte disorders, acid-base imbalance, and
Externí odkaz:
https://doaj.org/article/dbb7a6a1b07f46ae9a43e795a6a68c4e
Publikováno v:
Nutrition & Metabolism, Vol 18, Iss 1, Pp 1-11 (2021)
Nutrition & Metabolism
Nutrition & Metabolism
ObjectivesThe study of sex differences in hyperuricemia can provide not only a theoretical basis for this clinical phenomenon but also new therapeutic targets for urate-lowering therapy. In the current study, we aimed to confirm that estradiol can pr
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c45861a5476a0d40cb740e738b810155
https://doaj.org/article/7ec6453f219c41efa9a01b5c2eb7f985
https://doaj.org/article/7ec6453f219c41efa9a01b5c2eb7f985
Autor:
Ravi K. Narang, Nicola Dalbeth
Publikováno v:
Seminars in Nephrology. 40:550-563
Multiple interacting checkpoints are involved in the pathophysiology of gout. Hyperuricemia is the key risk factor for gout and is considered a prerequisite for monosodium urate (MSU) crystal formation. Urate underexcretion through renal and gut mech
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7021e7b17570b7d5232f1ff6f70dc5ef
https://doi.org/10.1016/j.semnephrol.2020.12.001
https://doi.org/10.1016/j.semnephrol.2020.12.001
Autor:
Philip Riches, George Nuki
Publikováno v:
Journal of the Royal College of Physicians of Edinburgh. 50:124-132
The incidence and prevalence of gout have increased, as have comorbid obesity, diabetes mellitus, hypertension, chronic kidney and cardiovascular disease. Gout is now the commonest type of inflammatory arthritis despite availability of safe, effectiv
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::fb878f86281be2dae3d60ca985592ce6
https://doi.org/10.4997/jrcpe.2020.209
https://doi.org/10.4997/jrcpe.2020.209
Contribution of Rare Variants of the SLC22A12 Gene to the Missing Heritability of Serum Urate Levels
Autor:
Masao Nagasaki, Kazuharu Misawa, Yosuke Kawai, Kaname Kojima, Eikan Mishima, Takanori Hasegawa, Promsuk Jutabha, Naohiko Anzai, Motoshi Ouchi, Masafumi Matsuo
Publikováno v:
Genetics. 214:1079-1090
Gout is a common arthritis caused by monosodium urate crystals. The heritability of serum urate levels is estimated to be 30–70%; however, common genetic variants account for only 7.9% of the variance in serum urate levels. This discrepancy is an e
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::39ebfeddcda6bf3c579befc69a73f3f8
https://doi.org/10.1534/genetics.119.303006
https://doi.org/10.1534/genetics.119.303006
Publikováno v:
Best Pract Res Clin Rheumatol
Circulating urate levels are determined by the balance between urate production and excretion, a homeostasis regulated by the function of urate transporters in key epithelial tissues and cell types. Our understanding of these physiological processes
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c0fbd512b4a50f0120970a6311fa5864
https://europepmc.org/articles/PMC8678298/
https://europepmc.org/articles/PMC8678298/
Publikováno v:
Clinical and experimental pharmacologyphysiologyREFERENCES. 48(12)
Disturbance in glucose and uric acid metabolism is the major disorder of metabolic syndrome (MetS). The kidneys play an important role in the management of glucose and uric acid. The aim of our study was to investigate alterations in renal glucose an
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0dc68b5b0f0802723f312ab01edbcea0
https://pubmed.ncbi.nlm.nih.gov/34407232
https://pubmed.ncbi.nlm.nih.gov/34407232