Zobrazeno 1 - 9
of 9
pro vyhledávání: '"Upul D Halambage"'
Autor:
Amanda J Price, David A Jacques, William A McEwan, Adam J Fletcher, Sebastian Essig, Jason W Chin, Upul D Halambage, Christopher Aiken, Leo C James
Publikováno v:
PLoS Pathogens, Vol 10, Iss 10, p e1004459 (2014)
The HIV-1 capsid is involved in all infectious steps from reverse transcription to integration site selection, and is the target of multiple host cell and pharmacologic ligands. However, structural studies have been limited to capsid monomers (CA), a
Externí odkaz:
https://doaj.org/article/af6eb117e61e461b8dd82edacf42765a
Autor:
Damien Ferhadian, Upul D. Halambage, Douglas K. Fischer, Mohammad Adnan Siddiqui, Christopher Aiken, Ashwanth C. Francis, Akatsuki Saito, Gregory B. Melikyan, Zandrea Ambrose, Masahiro Yamashita
The HIV-1 capsid executes essential functions that are regulated by capsid stability and host factors. In contrast to increasing knowledge on functional roles of capsid-interacting host proteins during postentry steps, less is known about capsid stab
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::247e60325b66df58b50b4d2be357a07f
https://europepmc.org/articles/PMC6675898/
https://europepmc.org/articles/PMC6675898/
Autor:
Jiong Shi, Upul D. Halambage, Juan Soto, Samantha Teng, Gregory A. Sowd, Christopher Aiken, Masahiro Yamashita, Damien Ferhadian, Erik Serrao, Mohammad Adnan Siddiqui, Alan Engelman, Akatsuki Saito
Publikováno v:
Journal of Virology. 90:5808-5823
The viral capsid of HIV-1 interacts with a number of host factors to orchestrate uncoating and regulate downstream events, such as reverse transcription, nuclear entry, and integration site targeting. PF-3450074 (PF74), an HIV-1 capsid-targeting low-
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::cf01ee93d1bfc2839e31342855a75a41
https://doi.org/10.1128/jvi.03116-15
https://doi.org/10.1128/jvi.03116-15
Publikováno v:
Journal of Virology. 89:9068-9079
During HIV-1 infection of cells, the viral capsid plays critical roles in reverse transcription and nuclear entry of the virus. The capsid-targeting small molecule PF74 inhibits HIV-1 at early stages of infection. HIV-1 resistance to PF74 is complex,
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::984bc01541fb425c9aa8b03021ed5b06
https://doi.org/10.1128/jvi.00340-15
https://doi.org/10.1128/jvi.00340-15
Autor:
Vaibhav Shah, Jiong Shi, Wade S. Blair, Hua Wu, Scott L. Butler, Upul D. Halambage, Jing Zhou, Mallori J. Burse, Christopher Aiken
Publikováno v:
Journal of Virology. 89:208-219
The HIV-1 capsid plays multiple roles in infection and is an emerging therapeutic target. The small-molecule HIV-1 inhibitor PF-3450074 (PF74) blocks HIV-1 at an early postentry stage by binding the viral capsid and interfering with its function. Sel
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5574323992e4564371ba5a5acf8be8c7
https://doi.org/10.1128/jvi.01411-14
https://doi.org/10.1128/jvi.01411-14
Autor:
Jing Zhou, Upul D. Halambage, Kellie A. Jurado, Weifeng Wang, Alan Engelman, Yujie Wang, Augusta Jamin, Christopher Aiken
Publikováno v:
Journal of virology. 91(9)
The human immunodeficiency virus type 1 (HIV-1) capsid protein is an attractive therapeutic target, owing to its multifunctionality in virus replication and the high fitness cost of amino acid substitutions in capsids to HIV-1 infectivity. To date, s
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::dbc62b6c86d8a5daf18e3ba25426b76f
https://pubmed.ncbi.nlm.nih.gov/28202766
https://pubmed.ncbi.nlm.nih.gov/28202766
Despite the availability of >30 effective drugs for managing HIV-1 infection, no current therapy is curative, and long-term management is challenging owing to the emergence and spread of drug-resistant mutants. Identification of drugs against novel H
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::099580910897a86d6afd1bab05e9e32b
https://europepmc.org/articles/PMC4538492/
https://europepmc.org/articles/PMC4538492/
Autor:
Adam J. Fletcher, Amanda J. Price, Christopher Aiken, William A. McEwan, David A. Jacques, Leo C. James, Upul D. Halambage, Jason W. Chin, Sebastian Essig
Publikováno v:
PLoS Pathogens
PLoS Pathogens, Vol 10, Iss 10, p e1004459 (2014)
PLoS Pathogens, Vol 10, Iss 10, p e1004459 (2014)
The HIV-1 capsid is involved in all infectious steps from reverse transcription to integration site selection, and is the target of multiple host cell and pharmacologic ligands. However, structural studies have been limited to capsid monomers (CA), a
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a1091f781c084e9ae92cbb42c142689c
https://doi.org/10.1371/journal.ppat.1004459
https://doi.org/10.1371/journal.ppat.1004459
Autor:
Amanda J. Price, David A. Jacques, Leo C. James, Christopher Aiken, Jason W. Chin, Thomas S. Elliott, Sebastian Essig, Upul D. Halambage
Publikováno v:
Acta Crystallographica Section A Foundations and Advances. 70:C120-C120
The capsid (CA) protein of HIV-1, which forms the core of the virus, has been shown to have an increasingly important role in the early stages of the virus lifecycle, in particular during reverse transcription and nuclear import. We recently solved t
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::658ab53e998701fd1a03941a44ab4b1d
https://doi.org/10.1107/s2053273314098799
https://doi.org/10.1107/s2053273314098799