Zobrazeno 1 - 10
of 75
pro vyhledávání: '"Upthagrove A"'
Autor:
Upthagrove, Alana1 (AUTHOR), Chen, Jin1 (AUTHOR), Meyers, Charles D.2 (AUTHOR), Kulmatycki, Kenneth1 (AUTHOR), Bretz, Angela3 (AUTHOR), Wang, Lai1 (AUTHOR), Peng, Lana1 (AUTHOR), Palamar, Safet1 (AUTHOR), Lin, Melissa4 (AUTHOR), Majumdar, Tapan1 (AUTHOR), Tran, Phi1 (AUTHOR), Einolf, Heidi J.1 (AUTHOR) heidi.einolf@novartis.com
Publikováno v:
Xenobiotica. Dec2017, Vol. 47 Issue 12, p1077-1089. 13p.
Autor:
W. Griffith Humphreys, Alana Upthagrove, Zhaopie Zeng, Bo Wen, Chandra Prakash, Suresh K. Balani, Heng-Keang Lim, Weichao Chen, Sekhar Surapaneni, Donghui Cui, Anthony J. Lee, Susanna Tse, Christopher MacLauchlin, Ling He, Jialin Mao, Robert L. Walsky, W. George Lai, Hongbin Yu
Publikováno v:
Drug Metabolism and Disposition. 43:620-630
Recent European Medicines Agency (final) and US Food and Drug Administration (draft) drug interaction guidances proposed that human circulating metabolites should be investigated in vitro for their drug-drug interaction (DDI) potential if present at
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8d2cf1c4ea6b879d4785b1d10476993d
https://doi.org/10.1124/dmd.114.059345
https://doi.org/10.1124/dmd.114.059345
Autor:
Kenneth Kulmatycki, Angela Bretz, Melissa Lin, Charles D. Meyers, Tapan K. Majumdar, Lana Peng, Alana Upthagrove, Phi Tran, Jin Chen, Lai Wang, Safet Palamar, Heidi J. Einolf
Publikováno v:
Xenobiotica; the fate of foreign compounds in biological systems. 47(12)
1. Pradigastat is a potent and specific diacylglycerol acyltransferase-1 (DGAT1) inhibitor effective in lowering postprandial triglycerides (TG) in healthy human subjects and fasting TG in familial chylomicronemia syndrome (FCS) patients. 2. Here we
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::aadaed0289d36bc9328e063d49d3cc25
https://pubmed.ncbi.nlm.nih.gov/27855567
https://pubmed.ncbi.nlm.nih.gov/27855567
Autor:
Wai-Si Eng, Xinchun Tong, Richard Tschirret-Guth, Song Zheng, Gary G. Chicchi, Geoge A. Doss, Koppara Samuel, Richard Hargreaves, Terence G. Hamill, Marc M. Kurtz, Robert J. DeVita, Sanjeev Kumar, Alan Wheeldon, Emma J. Carlson, Alana Upthagrove, Jaime Lynn Bunda, Stephen Krause, Jinlong Jiang, Christine Ryan, Sander G. Mills, Donald Burns, Kwei-Lan C. Tsao
Publikováno v:
Journal of Medicinal Chemistry. 52:3039-3046
3-[(3aR,4R,5S,7aS)-5-{(1R)-1-[3,5-bis(trifluoromethyl)phenyl]ethoxy}-4-(4-fluorophenyl)octahydro-2H-isoindol-2-yl]cyclopent-2-en-1-one (17) is a high affinity, brain-penetrant, hydroisoindoline-based neurokinin-1 (NK(1)) receptor antagonist with a lo
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d21762545018b32ec2dc16a2b6444d66
https://doi.org/10.1021/jm8016514
https://doi.org/10.1021/jm8016514
Publikováno v:
Rapid Communications in Mass Spectrometry. 13:1671-1679
Propranolol, its 1"-mono-, di-, and trifluorinated analogs, and other related compounds were analyzed under electrospray ionization ion trap collision-induced dissociation (ESI-CID) and electron impact (EI) conditions. Interesting trends were observe
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::46161a4a57fc4417f3212456c9c26ed2
https://doi.org/10.1002/(sici)1097-0231(19990830)13:16<1671::aid-rcm696>3.0.co
https://doi.org/10.1002/(sici)1097-0231(19990830)13:16<1671::aid-rcm696>3.0.co
Publikováno v:
Rapid Communications in Mass Spectrometry. 13:534-541
Propranolol, deuterium- and 18O-labeled propranolol and related compounds were analyzed using an ion trap mass spectrometer equipped with a modified Finnigan API electrospray interface. Sequential product ion (MSn) experiments were used to elucidate
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::5215091d1176804090e534c2496a0466
https://doi.org/10.1002/(sici)1097-0231(19990330)13:6<534::aid-rcm520>3.0.co
https://doi.org/10.1002/(sici)1097-0231(19990330)13:6<534::aid-rcm520>3.0.co
Publikováno v:
Journal of Medicinal Chemistry. 40:749-753
The E-isomer of 7-benzylidenenaltrexone (BNTX, la) was reported by Portoghese as a highly selective delta-opioid antagonist. The corresponding Z-isomer 1b was not readily available through direct aldol condensation of naltrexone (6) with benzaldehyde
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8e6b9692750fa2a6454d1814a087453c
https://doi.org/10.1021/jm960573f
https://doi.org/10.1021/jm960573f
Autor:
Alana Upthagrove, Kimberly Krone, Jos H. Beijnen, Jan H.M. Schellens, A. C. Dubbelman, Eugene Tan, Serena Marchetti, Suraj Anand
Publikováno v:
Cancer chemotherapy and pharmacology. 70(5)
This study investigated the metabolism and excretion of dovitinib (TKI258), a tyrosine kinase inhibitor that inhibits fibroblast, vascular endothelial, and platelet-derived growth factor receptors, in patients with advanced solid tumors.Four patients
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6824f8de7dcf0f50564d83fd98a481a3
https://pubmed.ncbi.nlm.nih.gov/23010851
https://pubmed.ncbi.nlm.nih.gov/23010851
Publikováno v:
Journal of the American Chemical Society. 108(19)
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4adf3955c24c9a065f6a8484ceccaf30
https://pubmed.ncbi.nlm.nih.gov/22175357
https://pubmed.ncbi.nlm.nih.gov/22175357
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