Zobrazeno 1 - 7
of 7
pro vyhledávání: '"Upendra Rao Anumala"'
Autor:
Katina Lazarow, Upendra Rao Anumala, Jo Waaler, Peter Lindemann, Alexander G. Majouga, Lari Lehtiö, Ezeogo Obaji, Alexander Ignatev, Sergey V. Leonov, Stefan Krauss, Marc Nazaré, Petter Angell Olsen, Y. Nkizinkiko, Sudarshan Murthy, Jens Peter von Kries
Publikováno v:
Journal of Medicinal Chemistry. 60:10013-10025
A structure-guided hybridization approach using two privileged substructures gave instant access to a new series of tankyrase inhibitors. The identified inhibitor 16 displays high target affinity on tankyrase 1 and 2 with biochemical and cellular IC5
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d3ca79a512d8987f5ce802da17ae9190
https://doi.org/10.1021/acs.jmedchem.7b00883
https://doi.org/10.1021/acs.jmedchem.7b00883
Autor:
Felix F. Fuchsberger, Jonas Aretz, Nandor Ziebart, Hengxi Zhang, Narges Molavi, Marc Nazaré, Christoph Rademacher, Upendra Rao Anumala
Publikováno v:
Journal of the American Chemical Society
Glycan-binding proteins are key components of central physiological and cellular processes such as self-/non-self-recognition, cellular tissue homing, and protein homeostasis. Herein, C-type lectins are a diverse protein family that play important ro
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::443793bcae0d572818832ba9db67c4fd
https://pubmed.ncbi.nlm.nih.gov/30303367
https://pubmed.ncbi.nlm.nih.gov/30303367
Immunotherapy alleviates amyloid-associated synaptic pathology in an Alzheimer's disease mouse model
Autor:
Heinz Hillen, Jochen Herms, Stefan Barghorn, Boris Schmidt, Upendra Rao Anumala, Mario M. Dorostkar, Steffen Burgold, Severin Filser, Corinna Klein
Publikováno v:
Brain
Brain 137(12), 3319-3326 (2014). doi:10.1093/brain/awu280
Brain 137(12), 3319-3326 (2014). doi:10.1093/brain/awu280
Accumulation of amyloid-beta leads to loss of functional synapses in Alzheimer’s disease. Dorostkar et al. report that immunotherapy against oligomeric amyloid-beta in the Tg2576 mouse model attenuates synapse loss near plaques, and abolishes it el
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8ed6bfd7cc11edd5f3f037762b48373f
https://pubmed.ncbi.nlm.nih.gov/25281869
https://pubmed.ncbi.nlm.nih.gov/25281869
Fluorescent rhodanine-3-acetic acids visualize neurofibrillary tangles in Alzheimer's disease brains
Autor:
Gerhard Mall, Christian Schön, Roland Heyny-von Haußen, Christian Czech, Jana Hölzer, Thomas Kramer, Jochen Herms, Boris Schmidt, Valerie Goetschy-Meyer, Ingrid Hilger, Jiamin Gu, Upendra Rao Anumala, Fabio Lo Monte
Publikováno v:
Bioorganic & medicinal chemistry 21(17), 5139-5144 (2013). doi:10.1016/j.bmc.2013.06.039
There is a high demand for the development of an imaging agent for neurofibrillary tangles (NFTs) detection in Alzheimer's diagnosis. In the present study, a series of rhodanine-3-acetic acids was synthesized and evaluated for fluorescence imaging of
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5770513ffb9ee75d9347104ebeea3158
https://pubmed.ncbi.nlm.nih.gov/23859773
https://pubmed.ncbi.nlm.nih.gov/23859773
Autor:
Upendra Rao Anumala, Roland Heyny-von Haußen, Ingrid Hilger, Valerie Goetschy-Meyer, Christian Czech, Jiamin Gu, Jana Hölzer, Boris Schmidt, Gerhard Mall
Publikováno v:
ChemMedChem. 8(6)
Shedding light on grey matter: Fluorescent trimethine cyanines were evaluated as imaging probes for neurofibrillary tangles in post-mortem brain sections of Alzheimer's disease patients. These probes bind to neurofibrillary tangles with high contrast
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::22d7f06508ac521b4fb6fa7fd330e8e0
https://pubmed.ncbi.nlm.nih.gov/23592568
https://pubmed.ncbi.nlm.nih.gov/23592568
Autor:
Ingrid Hilger, Thomas Kramer, Jiamin Gu, Valerie Goetschy-Meyer, Fabio Lo Monte, Gerhard Mall, Upendra Rao Anumala, Jana Hölzer, Boris Schmidt, Roland Heyny-von Haußen, Christian Czech
Publikováno v:
Bioorganicmedicinal chemistry letters. 22(24)
We evaluated 2-styrylindolium derivatives (6-11) as novel and selective probes for neurofibrillary tangles (NFTs) on brain sections of AD patients. The staining experiments indicated that these compounds may bind selectively to NFTs in the presence o
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ebc6daaee6739f3827bdb8c6462c13d8
https://pubmed.ncbi.nlm.nih.gov/23127889
https://pubmed.ncbi.nlm.nih.gov/23127889
Autor:
Batya Plotkin, Ettore Novellino, Juan Manuel Dominguez, Boris Schmidt, David Demedts, Ana Fuertes, Fred Van Leuven, Jiamin Gu, Luciana Marinelli, Valeria La Pietra, Fabio Lo Monte, Upendra Rao Anumala, Thomas Kramer, Bénédicte Franco, Hagit Eldar-Finkelman
Publikováno v:
Journal of medicinal chemistry. 55(9)
The glycogen synthase kinase-3 (GSK-3) has been linked to the pathogenesis of colorectal cancer, diabetes, cardiovascular disease, acute myeloid leukemia (AML), and Alzheimer's disease (AD). The debate on the respective contributions of GSK-3α and G
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::eb2353a9c1b942e2b5326a9ad82a23e4
https://pubmed.ncbi.nlm.nih.gov/22533818
https://pubmed.ncbi.nlm.nih.gov/22533818