Zobrazeno 1 - 8
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pro vyhledávání: '"Upasna Thapar"'
Autor:
Upasna Thapar, Bruce Demple
Publikováno v:
F1000Research, Vol 6 (2017)
Since the discovery of the base excision repair (BER) system for DNA more than 40 years ago, new branches of the pathway have been revealed at the biochemical level by in vitro studies. Largely for technical reasons, however, the confirmation of thes
Externí odkaz:
https://doaj.org/article/685c4e8c2a5d445da8d520e4ff1497d8
Autor:
M A Suresh Kumar, Michael Peluso, Pankaj Chaudhary, Jasbeer Dhawan, Afshin Beheshti, Krishnan Manickam, Upasna Thapar, Louis Pena, Mohan Natarajan, Lynn Hlatky, Bruce Demple, Mamta Naidu
Publikováno v:
PLoS ONE, Vol 10, Iss 7, p e0133016 (2015)
Ionizing radiation causes degeneration of myelin, the insulating sheaths of neuronal axons, leading to neurological impairment. As radiation research on the central nervous system has predominantly focused on neurons, with few studies addressing the
Externí odkaz:
https://doaj.org/article/ae1ff896d5704cbc9df3625b2c011e2b
Autor:
Nicholas G. Economos, Upasna Thapar, Nanda Balasubramanian, Georgios I. Karras, Peter M. Glazer
Publikováno v:
The Journal of biological chemistry. 298(10)
Unusual nucleic acid structures play vital roles as intermediates in many cellular processes and, in the case of peptide nucleic acid (PNA)-mediated triplexes, are leveraged as tools for therapeutic gene editing. However, due to their transient natur
Autor:
Bruce Demple, Upasna Thapar
Publikováno v:
DNA Repair. 76:11-19
There exist two major base excision DNA repair (BER) pathways, namely single-nucleotide or “short-patch” (SP-BER), and “long-patch” BER (LP-BER). Both pathways appear to be involved in the repair of small base lesions such as uracil, abasic s
Autor:
Upasna Thapar, Bruce Demple
Publikováno v:
Encyclopedia of Biological Chemistry III ISBN: 9780128220405
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::8015e6fb6300d13f7222e229d4dc9ccd
https://doi.org/10.1016/b978-0-12-819460-7.00247-4
https://doi.org/10.1016/b978-0-12-819460-7.00247-4
Publikováno v:
Proceedings of the National Academy of Sciences. 112:8602-8607
Free radical attack on the C1' position of DNA deoxyribose generates the oxidized abasic (AP) site 2-deoxyribonolactone (dL). Upon encountering dL, AP lyase enzymes such as DNA polymerase β (Polβ) form dead-end, covalent intermediates in vitro duri
Publikováno v:
Cell Stress and Chaperones. 18:321-331
Protein folding and disaggregation are crucial processes for survival of cells under unfavorable conditions. A network of molecular chaperones supports these processes. Collaborative action of Hsp70 and Hsp100 proteins is an important component of th
Autor:
Lynn Hlatky, M. A. Suresh Kumar, Upasna Thapar, Krishnan Manickam, Pankaj Chaudhary, Afshin Beheshti, Jasbeer Dhawan, Mohan Natarajan, Michael J. Peluso, Bruce Demple, Mamta D. Naidu, Louis A. Peña
Publikováno v:
PLoS ONE, Vol 10, Iss 7, p e0133016 (2015)
PLoS ONE
Suresh Kumar, M A, Peluso, M, Chaudhary, P, Dhawan, J, Beheshti, A, Manickam, K, Thapar, U, Pena, L, Natarajan, M, Hlatky, L, Demple, B & Naidu, M 2015, ' Fractionated Radiation Exposure of Rat Spinal Cords Leads to Latent Neuro-Inflammation in Brain, Cognitive Deficits,and Alterations in Apurinic Endonuclease 1 ', PLoS ONE, vol. 10, no. 7, e0133016 . https://doi.org/10.1371/journal.pone.0133016
PLoS ONE
Suresh Kumar, M A, Peluso, M, Chaudhary, P, Dhawan, J, Beheshti, A, Manickam, K, Thapar, U, Pena, L, Natarajan, M, Hlatky, L, Demple, B & Naidu, M 2015, ' Fractionated Radiation Exposure of Rat Spinal Cords Leads to Latent Neuro-Inflammation in Brain, Cognitive Deficits,and Alterations in Apurinic Endonuclease 1 ', PLoS ONE, vol. 10, no. 7, e0133016 . https://doi.org/10.1371/journal.pone.0133016
Ionizing radiation causes degeneration of myelin, the insulating sheaths of neuronal axons, leading to neurological impairment. As radiation research on the central nervous system has predominantly focused on neurons, with few studies addressing the