Zobrazeno 1 - 10
of 11
pro vyhledávání: '"Upasana L. Mallimadugula"'
Autor:
Matthew A. Cruz, Thomas E. Frederick, Upasana L. Mallimadugula, Sukrit Singh, Neha Vithani, Maxwell I. Zimmerman, Justin R. Porter, Katelyn E. Moeder, Gaya K. Amarasinghe, Gregory R. Bowman
Publikováno v:
Nature Communications, Vol 13, Iss 1, Pp 1-10 (2022)
Many viral proteins are thought to be unlikely candidates for drug discovery as they lack obvious drug binding sites. Here, the authors use computational approaches followed by experimental validation to identify a cryptic pocket within the Ebola vir
Externí odkaz:
https://doaj.org/article/b1138d9e9bae403da917984ac9c6ee9b
Autor:
Melissa D. Stuchell-Brereton, Maxwell I. Zimmerman, Justin J. Miller, Upasana L. Mallimadugula, J. Jeremías Incicco, Debjit Roy, Louis G. Smith, Jasmine Cubuk, Berevan Baban, Gregory T. DeKoster, Carl Frieden, Gregory R. Bowman, Andrea Soranno
Publikováno v:
Proceedings of the National Academy of Sciences. 120
The ε4-allele variant of apolipoprotein E (ApoE4) is the strongest genetic risk factor for Alzheimer’s disease, although it only differs from its neutral counterpart ApoE3 by a single amino acid substitution. While ApoE4 influences the formation o
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::982d41c6d061a85d64b3f74b0017d55a
https://doi.org/10.1073/pnas.2215371120
https://doi.org/10.1073/pnas.2215371120
Autor:
Sukrit Singh, Catherine E. Kuhn, Aoife M. Harbison, Vincent A. Voelz, John D. Chodera, Justin R. Porter, Neha Vithani, Joseph E. Coffland, Rafal P. Wiewiora, Artur Meller, Carl A Fogarty, Maxwell I. Zimmerman, Jonathan H. Borowsky, Gregory R. Bowman, Michael D. Ward, Matthew F. D. Hurley, Elisa Fadda, Upasana L. Mallimadugula
Publikováno v:
Nature Chemistry. 13:651-659
SARS-CoV-2 has intricate mechanisms for initiating infection, immune evasion/suppression and replication that depend on the structure and dynamics of its constituent proteins. Many protein structures have been solved, but far less is known about thei
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::616c72101f8be9aa1b5000974b96797a
https://doi.org/10.1038/s41557-021-00707-0
https://doi.org/10.1038/s41557-021-00707-0
Autor:
Melissa D. Stuchell-Brereton, Maxwell I. Zimmerman, Justin J. Miller, Upasana L. Mallimadugula, J. Jeremias Incicco, Debjit Roy, Louis G. Smith, Berevan Baban, Gregory T. DeKoster, Carl Frieden, Gregory R. Bowman, Andrea Soranno
The ε4-allele variant of Apolipoprotein E (ApoE4) is the strongest genetic risk factor for Alzheimer’s disease, though it only differs from its neutral counterpart ApoE3 by a single amino acid substitution. While ApoE4 influences the formation of
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::7150579344a81feb2ed19d91697f30c4
https://doi.org/10.1101/2022.02.02.478828
https://doi.org/10.1101/2022.02.02.478828
Autor:
Melissa D. Stuchell-Brereton, Maxwell I. Zimmerman, Justin J. Miller, Upasana L. Mallimadugula, Juan J. Incicco, Debjit Roy, Louis G. Smith, Jasmine Cubuk, Berevan Baban, Gregory T. DeKoster, Carl Frieden, Gregory R. Bowman, Andrea Soranno
Publikováno v:
Biophysical Journal. 122:329a
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::e2cd2c4d2c7261e4aab52d66d8e37a8a
https://doi.org/10.1016/j.bpj.2022.11.1840
https://doi.org/10.1016/j.bpj.2022.11.1840
Autor:
Sukrit Singh, Gregory R. Bowman, Neha Vithani, Thomas E. Frederick, Maxwell I. Zimmerman, Matthew A. Cruz, Justin R. Porter, Katelyn E. Moeder, Gaya K. Amarasinghe, Upasana L. Mallimadugula
Publikováno v:
Nature communications. 13(1)
Protein-protein and protein-nucleic acid interactions are often considered difficult drug targets because the surfaces involved lack obvious druggable pockets. Cryptic pockets could present opportunities for targeting these interactions, but identify
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9515edf7ff74025634ed131311a4bafc
https://pubmed.ncbi.nlm.nih.gov/35477718
https://pubmed.ncbi.nlm.nih.gov/35477718
Autor:
Melissa D. Stuchell-Brereton, Maxwell I. Zimmerman, Upasana L. Mallimadugula, J. Jeremias Incicco, Debjit Roy, Berevan Baban, Gregory T. DeKoster, Gregory Bowman, Carl Frieden, Andrea Soranno
Publikováno v:
Biophysical Journal. 121:182a-183a
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::6030addd3abebac20d78830b9fbfd856
https://doi.org/10.1016/j.bpj.2021.11.1841
https://doi.org/10.1016/j.bpj.2021.11.1841
Autor:
Shreya Raavicharla, Gregory R. Bowman, Upasana L. Mallimadugula, Catherine R. Knoverek, Lewis E. Kay, Thomas E. Frederick, Tairan Yuwen, Enrico Rennella, Sukrit Singh
Publikováno v:
Proceedings of the National Academy of Sciences of the United States of America
Significance A protein is a shape-shifter, but it is currently unclear which of the many structures a protein can adopt are relevant for its function. Here, we examine conformations that contain a “cryptic” pocket (i.e., a pocket absent in ligand
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::bc2bbfa535eaff8c8c2d57de2e3f1e73
https://doi.org/10.1101/2021.04.14.439842
https://doi.org/10.1101/2021.04.14.439842
Autor:
Sukrit Singh, Rafal P. Wiewiora, John D. Chodera, Upasana L. Mallimadugula, Aoife M. Harbison, Maxwell I. Zimmerman, Jonathan H. Borowsky, Vincent A. Voelz, Matthew F. D. Hurley, Neha Vithani, Carl A Fogarty, Elisa Fadda, Gregory R. Bowman, Catherine E. Kuhn, Justin R. Porter, Joseph E. Coffland, Michael D. Ward, Artur Meller
Publikováno v:
Nature chemistry
bioRxiv
article-version (status) pre
article-version (number) 1
bioRxiv
article-version (status) pre
article-version (number) 1
SARS-CoV-2 has intricate mechanisms for initiating infection, immune evasion/suppression, and replication, which depend on the structure and dynamics of its constituent proteins. Many protein structures have been solved, but far less is known about t
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::95257af65179851fa72f91112ad7fd25
https://pubmed.ncbi.nlm.nih.gov/34031561
https://pubmed.ncbi.nlm.nih.gov/34031561
Molecular motors convert chemical potential energy into mechanical work and perform a great number of critical biological functions. Examples include the polymerization and manipulation of nucleic acids, the generation of cellular motility and contra
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c15efd936115896f5a517e201617adc0
https://doi.org/10.1101/2020.06.29.177964
https://doi.org/10.1101/2020.06.29.177964