Sinococuline, a bioactive compound of Cocculus hirsutus has potent anti-dengue activity

Autor: Rahul Shukla, Richa Ahuja, Hemalatha Beesetti, Amit Garg, Charu Aggarwal, Shivam Chaturvedi, Kaushal Nayyar, Upasana Arora, Altaf A. Lal, Navin Khanna

Publikováno v: Scientific Reports, Vol 13, Iss 1, Pp 1-13 (2023)

Abstract Dengue virus (DENV) infection has increased worldwide, with over 400 million infections annually, and has become a serious public health concern. Several drug candidates, new and repurposed, have failed to meet the primary efficacy endpoints

Externí odkaz: https://doaj.org/article/a860b24033fc49ecb4dc07f2af65c5c4

Cocculus hirsutus-Derived Phytopharmaceutical Drug Has Potent Anti-dengue Activity

Autor: Rahul Shukla, Ravi Kant Rajpoot, Ankur Poddar, Richa Ahuja, Hemalatha Beesetti, Rajgokul K. Shanmugam, Shivam Chaturvedi, Kaushal Nayyar, Deepika Singh, Venugopal Singamaneni, Prasoon Gupta, Ajai Prakash Gupta, Sumeet Gairola, Pankaj Kumar, Y. S. Bedi, Tapesh Jain, Bhupendra Vashishta, Ravindra Patil, Harish Madan, Sumit Madan, Rinku Kalra, Ruchi Sood, Ram A. Vishwakarma, D. Srinivasa Reddy, Altaf A. Lal, Upasana Arora, Navin Khanna

Publikováno v: Frontiers in Microbiology, Vol 12 (2021)

Dengue is a serious public health concern worldwide, with ∼3 billion people at risk of contracting dengue virus (DENV) infections, with some suffering severe consequences of disease and leading to death. Currently, there is no broad use vaccine or

Externí odkaz: https://doaj.org/article/a2f36b9d0b3b4046aab203f00ae8f603

Zika virus envelope nanoparticle antibodies protect mice without risk of disease enhancement

Autor: Rahul Shukla, Rajgokul K. Shanmugam, Viswanathan Ramasamy, Upasana Arora, Gaurav Batra, Joshua A. Acklin, Florian Krammer, Jean K. Lim, Sathyamangalam Swaminathan, Navin Khanna

Publikováno v: EBioMedicine, Vol 54, Iss , Pp - (2020)

Background: Zika virus (ZIKV), an arbovirus capable of causing neurological abnormalities, is a recognised human pathogen, for which a vaccine is required. As ZIKV antibodies can mediate antibody-dependent enhancement (ADE) of dengue virus (DENV) inf

Externí odkaz: https://doaj.org/article/318a15f4a8aa490596960af464bec206

A tetravalent virus-like particle vaccine designed to display domain III of dengue envelope proteins induces multi-serotype neutralizing antibodies in mice and macaques which confer protection against antibody dependent enhancement in AG129 mice.

Autor: Viswanathan Ramasamy, Upasana Arora, Rahul Shukla, Ankur Poddar, Rajgokul K Shanmugam, Laura J White, Melissa M Mattocks, Rajendra Raut, Ashiya Perween, Poornima Tyagi, Aravinda M de Silva, Siddhartha K Bhaumik, Murali Krishna Kaja, François Villinger, Rafi Ahmed, Robert E Johnston, Sathyamangalam Swaminathan, Navin Khanna

Publikováno v: PLoS Neglected Tropical Diseases, Vol 12, Iss 1, p e0006191 (2018)

Dengue is one of the fastest spreading vector-borne diseases, caused by four antigenically distinct dengue viruses (DENVs). Antibodies against DENVs are responsible for both protection as well as pathogenesis. A vaccine that is safe for and efficacio

Externí odkaz: https://doaj.org/article/1493e4510e824e5a9dcf9fc2b8abf687

List of contributors

Autor: Ahmad Zuhairi Abdullah, Mohamed Hussein Abdurahman, Bashir Adelodun, Israel Adedayo Adeoye, James Rotimi Adewumi, Rajeshwar Rao Aerva, Pallavi Agarwal, Moeed Ahmad, Fidelis Odedishemi Ajibade, Temitope Fausat Ajibade, Nadia Andrade Aleixo, Jesús Alvarado-Flores, Afreenish Amir, Upasana Arora, Usman Ali Ashfaq, Bilal Aslam, Abhay Bajaj, Zulqarnain Baloch, Ankita Bharshankh, Sparsh Bhatia, Muhammad Bilal, Rima Biswas, Shishir Bobate, Stephen Browne, Rodrigo Bueno, Tamoor Hamid Chaudhry, Nalini Singh Chauhan, Lúcia Helena Gomes Coelho, Nishant A. Dafale, C. Shobha Devi, Alvina Farooqui, Rohan Gupta, Sumreen Hayat, Mahima Kaushik, Mohsin Khurshid, Pankaj Kumar, Kayode Hassan Lasisi, Ting Li, Sejal Mahalle, Saima Muzammil, Penumaka Nagababu, Muhammad Atif Nisar, Nathaniel Azibuike Nwogwu, Olawale Olugbenga Olanrewaju, Ifeoluwa Funmilola Omotade, Sukdeb Pal, Deepak Panchal, Ailton Barbosa Perdão, Ignacio Alejandro Pérez-Legaspi, Om Prakash, Abhay Punia, Muhammad Shahid Riaz Rajoka, Muhammad Hidayat Rasool, Roberto Rico-Martínez, Daniel Robles-Vargas, Bijaylaxmi Sahoo, Muhammad Salman, Gustavo Emilio Santos-Medrano, Niloy Sarkar, Anderson Schmeing, Shradhanjali Sethi, Aqsa Shahid, Abhishek Sharma, Noor Fazliani Shopware, Abu Baker Siddique, Jéssica Demitrol Silva, Neha Singh, Shweta Srivastava, Eduardo Lucas Subtil, Muhammad Usama Tariq, Purusottam Tripathy, Xiumin Wang, Oh Wen Da, Shailendra Yadav, Kamran Zaman

Publikováno v: Degradation of Antibiotics and Antibiotic-Resistant Bacteria from Various Sources ISBN: 9780323998666

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::202945a0c907c166df43309a11a6d4ee
https://doi.org/10.1016/b978-0-323-99866-6.00022-2