Bivalent intra-spike binding provides durability against emergent Omicron lineages: Results from a global consortium.

Autor: Callaway HM; Center for Infectious Disease and Vaccine Research, La Jolla Institute for Immunology, La Jolla, CA 92037, USA., Hastie KM; Center for Infectious Disease and Vaccine Research, La Jolla Institute for Immunology, La Jolla, CA 92037, USA., Schendel SL; Center for Infectious Disease and Vaccine Research, La Jolla Institute for Immunology, La Jolla, CA 92037, USA., Li H; Center for Infectious Disease and Vaccine Research, La Jolla Institute for Immunology, La Jolla, CA 92037, USA., Yu X; Center for Infectious Disease and Vaccine Research, La Jolla Institute for Immunology, La Jolla, CA 92037, USA., Shek J; Center for Infectious Disease and Vaccine Research, La Jolla Institute for Immunology, La Jolla, CA 92037, USA., Buck T; Center for Infectious Disease and Vaccine Research, La Jolla Institute for Immunology, La Jolla, CA 92037, USA., Hui S; Center for Infectious Disease and Vaccine Research, La Jolla Institute for Immunology, La Jolla, CA 92037, USA., Bedinger D; Carterra, 825 N. 300 W. Ste. C309, Salt Lake City, UT 84103, USA., Troup C; Carterra, 825 N. 300 W. Ste. C309, Salt Lake City, UT 84103, USA., Dennison SM; Center for Human Systems Immunology, Departments of Surgery, Immunology, and Molecular Genetics and Microbiology and Duke Human Vaccine Institute, Duke University, Durham, NC 27701, USA., Li K; Center for Human Systems Immunology, Departments of Surgery, Immunology, and Molecular Genetics and Microbiology and Duke Human Vaccine Institute, Duke University, Durham, NC 27701, USA., Alpert MD; Emmune, Inc., 14155 US Highway 1, Juno Beach, FL 33408, USA., Bailey CC; Emmune, Inc., 14155 US Highway 1, Juno Beach, FL 33408, USA., Benzeno S; Adaptive Biotechnologies, 1551 Eastlake Ave East, Seattle, WA 98102, USA., Bonnevier JL; Bio-techne, 614 McKinley Place NE, Minneapolis, MN 55413, USA., Chen JQ; ACRO Biosystems, 1 Innovation Way, Newark, DE 19711, USA., Chen C; ACRO Biosystems, 1 Innovation Way, Newark, DE 19711, USA., Cho H; Antibody Biology Unit, Laboratory of Immunogenetics, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Rockville, MD 20852, USA; Malaria Infection Biology and Immunity Section, Laboratory of Immunogenetics, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Rockville, MD 20852, USA., Crompton PD; Antibody Biology Unit, Laboratory of Immunogenetics, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Rockville, MD 20852, USA; Malaria Infection Biology and Immunity Section, Laboratory of Immunogenetics, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Rockville, MD 20852, USA., Dussupt V; Emerging Infectious Diseases Branch, Walter Reed Army Institute of Research, Silver Spring, MD, USA; Henry M. Jackson Foundation for the Advancement of Military Medicine, Bethesda, MD, USA., Entzminger KC; Abwiz Bio, Inc., 9823 Pacific Heights Blvd. Suite J, San Diego, CA 92121, USA., Ezzyat Y; Jounce Therapeutics, Inc., 780 Memorial Drive, Cambridge, MA 02139, USA., Fleming JK; Abwiz Bio, Inc., 9823 Pacific Heights Blvd. Suite J, San Diego, CA 92121, USA., Geukens N; PharmAbs, The KU Leuven Antibody Center, KU Leuven, 3000 Leuven, Belgium., Gilbert AE; Adaptive Biotechnologies, 1551 Eastlake Ave East, Seattle, WA 98102, USA., Guan Y; Antibody BioPharm, Inc., 401 Professional Dr Ste 241, Gaithersburg, MD 20879, USA; Shanghai Life Technology Co., Ltd., 781 Cai Lun Rd, Ste 801, Pudong, Shanghai 201203, China., Han X; Department of Immunology, College of Basic Medicine, Chongqing Medical University, Chongqing 400010, China., Harvey CJ; Jounce Therapeutics, Inc., 780 Memorial Drive, Cambridge, MA 02139, USA; Phenomic AI, 661 University Avenue, Suite 1300 MaRS Centre, West Tower, Toronto, ON M5G 0B7, Canada., Hatler JM; Bio-techne, 614 McKinley Place NE, Minneapolis, MN 55413, USA., Howie B; Adaptive Biotechnologies, 1551 Eastlake Ave East, Seattle, WA 98102, USA., Hu C; Department of Immunology, College of Basic Medicine, Chongqing Medical University, Chongqing 400010, China., Huang A; Key Laboratory of Molecular Biology for Infectious Diseases (Ministry of Education), Institute for Viral Hepatitis, Department of Infectious Diseases, The Second Affiliated Hospital, Chongqing Medical University, Chongqing 400010, China., Imbrechts M; PharmAbs, The KU Leuven Antibody Center, KU Leuven, 3000 Leuven, Belgium., Jin A; Department of Immunology, College of Basic Medicine, Chongqing Medical University, Chongqing 400010, China., Kamachi N; ACRO Biosystems, 1 Innovation Way, Newark, DE 19711, USA., Keitany G; Adaptive Biotechnologies, 1551 Eastlake Ave East, Seattle, WA 98102, USA., Klinger M; Adaptive Biotechnologies, 1551 Eastlake Ave East, Seattle, WA 98102, USA., Kolls JK; Tulane School of Medicine, Center for Translational Research in Infection and Inflammation, New Orleans, LA 70112, USA., Krebs SJ; Emerging Infectious Diseases Branch, Walter Reed Army Institute of Research, Silver Spring, MD, USA; Henry M. Jackson Foundation for the Advancement of Military Medicine, Bethesda, MD, USA., Li T; Department of Immunology, College of Basic Medicine, Chongqing Medical University, Chongqing 400010, China., Luo F; Department of Immunology, College of Basic Medicine, Chongqing Medical University, Chongqing 400010, China., Maruyama T; Abwiz Bio, Inc., 9823 Pacific Heights Blvd. Suite J, San Diego, CA 92121, USA., Meehl MA; Jounce Therapeutics, Inc., 780 Memorial Drive, Cambridge, MA 02139, USA., Mendez-Rivera L; Emerging Infectious Diseases Branch, Walter Reed Army Institute of Research, Silver Spring, MD, USA; Henry M. Jackson Foundation for the Advancement of Military Medicine, Bethesda, MD, USA., Musa A; Adaptive Biotechnologies, 1551 Eastlake Ave East, Seattle, WA 98102, USA., Okumura CJ; Abwiz Bio, Inc., 9823 Pacific Heights Blvd. Suite J, San Diego, CA 92121, USA., Rubin BER; Adaptive Biotechnologies, 1551 Eastlake Ave East, Seattle, WA 98102, USA., Sato AK; Twist Bioscience, 681 Gateway Blvd., South San Francisco, CA 94080, USA., Shen M; Department of Endocrine Breast Surgery, The First Affiliated Hospital of Chongqing Medical University, Chongqing 400010, China., Singh A; Jounce Therapeutics, Inc., 780 Memorial Drive, Cambridge, MA 02139, USA., Song S; Department of Immunology, College of Basic Medicine, Chongqing Medical University, Chongqing 400010, China., Tan J; Antibody Biology Unit, Laboratory of Immunogenetics, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Rockville, MD 20852, USA., Trimarchi JM; Emmune, Inc., 14155 US Highway 1, Juno Beach, FL 33408, USA; Department of Biological Sciences, Lehigh University, 111 Research Drive, Bethlehem, PA 18015, USA., Upadhyay DP; Jounce Therapeutics, Inc., 780 Memorial Drive, Cambridge, MA 02139, USA; Amgen, Inc., 360 Binney St., Cambridge, MA 02141, USA., Wang Y; Department of Immunology, College of Basic Medicine, Chongqing Medical University, Chongqing 400010, China., Yu L; Guangzhou Eighth People's Hospital & Guangzhou Medical University, Guangzhou 510060, China., Yuan TZ; Twist Bioscience, 681 Gateway Blvd., South San Francisco, CA 94080, USA., Yusko E; Adaptive Biotechnologies, 1551 Eastlake Ave East, Seattle, WA 98102, USA., Peters B; Center for Infectious Disease and Vaccine Research, La Jolla Institute for Immunology, La Jolla, CA 92037, USA; Department of Medicine, University of California San Diego, La Jolla, CA 92039, USA., Tomaras G; Center for Human Systems Immunology, Departments of Surgery, Immunology, and Molecular Genetics and Microbiology and Duke Human Vaccine Institute, Duke University, Durham, NC 27701, USA., Saphire EO; Center for Infectious Disease and Vaccine Research, La Jolla Institute for Immunology, La Jolla, CA 92037, USA; Department of Medicine, University of California San Diego, La Jolla, CA 92039, USA. Electronic address: erica@lji.org.

Publikováno v: Cell reports [Cell Rep] 2023 Jan 31; Vol. 42 (1), pp. 112014. Date of Electronic Publication: 2023 Jan 12.