BMP7 increases protein synthesis in SW1353 cells and determines rRNA levels in a NKX3-2-dependent manner

Autor: Ellen G. J. Ripmeester, Tim J. M. Welting, Guus G. H. van den Akker, Don A. M. Surtel, Jessica S. J. Steijns, Andy Cremers, Lodewijk W. van Rhijn, Marjolein M. J. Caron

Publikováno v: PLOS ONE, 17(2):e0263430. Public Library of Science
PLoS ONE, Vol 17, Iss 2 (2022)

BMP7 is a morphogen capable of counteracting the OA chondrocyte hypertrophic phenotype via NKX3-2. NKX3-2 represses expression of RUNX2, an important transcription factor for chondrocyte hypertrophy. Since RUNX2 has previously been described as an in

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::50b91411d9a3772f259276cff0fffa8e
https://doi.org/10.1371/journal.pone.0263430

Dysregulation of macrophage development and phenotype in diabetic human macrophages can be rescued by Hoxa3 protein transduction

Autor: Kimberly A. Mace, Edward A. McKenzie, Andrew J.M. Boulton, Tanja Torbica, Frank L. Bowling, Hadeel Al Sadoun, Salma Alrdahe

Publikováno v: Alrdahe, S, Al Sadoun, H, Torbica, T, McKenzie, E A, Bowling, F L, Boulton, A J M & Mace, K A 2019, ' Dysregulation of macrophage development and phenotype in diabetic human macrophages can be rescued by Hoxa3 protein transduction ', PLoS One., vol. 14, no. 10, pp. e0223980 . https://doi.org/10.1371/journal.pone.0223980, https://doi.org/10.1371/journal.pone.0223980
PLoS ONE, Vol 14, Iss 10, p e0223980 (2019)
PLoS ONE

Controlled inflammatory responses of myeloid cells recruited to wounds are essential for effective repair. In diabetes, the inflammatory response is prolonged and augmented over time, with increased myeloid cells present in the wound that fail to swi

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9d6ea39074a79895983e43418ef1be36
https://doi.org/10.1371/journal.pone.0223980

Type I interferon-mediated autoinflammation due to DNase II deficiency

Autor: Flavio Faletra, Gabriele Stocco, Evelyn Hartmann, Chantal Brouzes, Flavia Guillem, Fabrice Porcheray, Florence Uettwiller, Carolina Uggenti, Diego Vozzi, Marion Rabant, Capucine Picard, Nicolas Cagnard, Elisa Piscianz, Olivier Hermine, Andrea Taddio, Sophie Candon, Gunther Hartmann, Leo A. H. Zeef, Pierre Quartier, Marie Alexandra Alyanakian, Brigitte Bader-Meunier, Benoit Beitz, Gillian I. Rice, Muriel Girard, Monique Fabre, Alberto Tommasini, Dominique Lasne, Marine Depp, Nathalie Boddaert, Mathieu P Rodero, Stefano Volpi, Marco Gattorno, Yanick J. Crow, Eva Bartok, Michael Dussiot, Michel Polak, Tiffany Pascreau, Roberta Caorsi, Erika Della Mina, Naoki Kitabayashi, Annalisa Marcuzzi, Vincent Bondet, Paolo Picco, Luis Seabra, Jacques Beltrand, Erica Valencic, Marie-Louise Frémond, Bénédicte Neven, Frédéric Rieux-Laucat, Darragh Duffy, Alessandra Tesser, Patrick Nitschke, Anna Monica Bianco, Marina Charbit, Annie Harroche, Serena Pastore, Winfried Barchet

Publikováno v: Nature Communications
Nature Communications, Nature Publishing Group, 2017, 8 (1), pp.2176. ⟨10.1038/s41467-017-01932-3⟩
Nature Communications, Vol 8, Iss 1, Pp 1-15 (2017)
Nature Communications, Nature Publishing Group, 2017, 8 (1), ⟨10.1038/S41467-017-01932-3⟩
Rodero, M P, Tesser, A, Bartok, E, Rice, G I, Della Mina, E, Depp, M, Beitz, B, Bondet, V, Cagnard, N, Duffy, D, Dussiot, M, Frémond, M, Gattorno, M, Guillem, F, Kitabayashi, N, Porcheray, F, Rieux-laucat, F, Seabra, L, Uggenti, C, Volpi, S, Zeef, L A H, Alyanakian, M, Beltrand, J, Bianco, A M, Boddaert, N, Brouzes, C, Candon, S, Caorsi, R, Charbit, M, Fabre, M, Faletra, F, Girard, M, Harroche, A, Hartmann, E, Lasne, D, Marcuzzi, A, Neven, B, Nitschke, P, Pascreau, T, Pastore, S, Picard, C, Picco, P, Piscianz, E, Polak, M, Quartier, P, Rabant, M, Stocco, G, Taddio, A, Uettwiller, F, Valencic, E, Vozzi, D, Hartmann, G, Barchet, W, Hermine, O, Bader-meunier, B, Tommasini, A & Crow, Y J 2017, ' Type I interferon-mediated autoinflammation due to DNase II deficiency ', Nature Communications, vol. 8, no. 1, 2176 . https://doi.org/10.1038/s41467-017-01932-3
Nature Communications, 2017, 8 (1), pp.2176. ⟨10.1038/s41467-017-01932-3⟩
Rodero, M P, Tesser, A, Bartok, E, Rice, G, Della Mina, E, Depp, M, Beitz, B, Bondet, V, Cagnard, N, Duffy, D, Dussiot, M, Fremond, M-L, Gattorno, M, Guillem, F, Kitabayashi, N, Porcheray, F, Rieux-Laucat, F, Seabra, L, Uggenti, C, Volpi, S, Zeef, L, Alyanakian, M-A, Beltrand, J, Bianco, A M, Boddaert, N, Brouzes, C, Candon, S, Caorsi, R, Charbit, M, Fabre, M, Faletra, F, Girard, M, Harroche, A, Hartmann, E, Lasne, D, Marcuzzi, A, Neven, B, Nitschke, P, Pascreau, T, Pastore, S, Picard, C, Picco, P P, Piscianz, E, Polak, M, Quartier, P, Rabant, M, Stocco, G, Taddio, A, Uettwiller, F, Valencic, E, Vozzi, D, Hartmann, G, Barchet, W, Hermine, O, Bader-Meunier, B, Tommasini, A & Crow, Y 2017, ' Type I interferon mediated autoinflammation due to DNase II deficiency ', Nature Communications, vol. 8, 2176 . https://doi.org/10.1038/s41467-017-01932-3

Microbial nucleic acid recognition serves as the major stimulus to an antiviral response, implying a requirement to limit the misrepresentation of self nucleic acids as non-self and the induction of autoinflammation. By systematic screening using a p

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d7996f15867050dcd49eb11d20f8f073
https://hal-pasteur.archives-ouvertes.fr/pasteur-01768950/document

Metformin, but Not Rosiglitazone, Attenuates the Increasing Plasma Levels of a New Cardiovascular Marker, Fibulin-1, in Patients With Type 2 Diabetes

Autor: Mette Marie Hougaard Christensen, Vibe Skov, Claudia Cangemi, Ellen Grodum, W. Scott Argraves, Ditte Sørensen, Jan Erik Henriksen, Jeppe Gram, Lars Melholt Rasmussen

Publikováno v: Skov, V, Cangemi, C, Gram, J, Christensen, M M, Grodum, E, Sørensen, D, Argraves, W S, Henriksen, J E & Rasmussen, L M 2014, ' Metformin, but not rosiglitazone, attenuates the increasing plasma levels of a new cardiovascular marker, fibulin-1, in patients with type 2 diabetes ', Diabetes Care, vol. 37, no. 3, pp. 760-766 . https://doi.org/10.2337/dc13-1022

OBJECTIVE The extracellular matrix protein fibulin-1 is upregulated in the arterial wall in type 2 diabetes (T2D) and circulates in increased concentrations in diabetes. Metformin is an antidiabetic drug with beneficial cardiovascular disease effects

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b8bc68ca653065c320e21256ed74fae7
https://doi.org/10.2337/dc13-1022

Nogo-A Downregulation Improves Insulin Secretion in Mice

Autor: Patrice H. Lalive, Claire Bonal, Mahdia Benkhoucha, Caroline Pot, Martin E. Schwab, Delphine Baronnier, Pedro Luis Herrera

Publikováno v: Diabetes
Diabetes, Vol. 62, No 5 (2013) pp. 1443-52

Type 2 diabetes (T2D) is characterized by β-cell dysfunction and the subsequent depletion of insulin production, usually in a context of increased peripheral insulin resistance. T2D patients are routinely treated with oral antidiabetic agents such a

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d04e605952a6685accbf36248b8cf857
http://europepmc.org/articles/PMC3636604