Photosensitive Alternative Splicing of the Circadian Clock Gene timeless Is Population Specific in a Cold-Adapted Fly, Drosophila montana

Autor: Tapanainen, Riikka, Parker, Darren J., Kankare, Maaria

Publikováno v: G3, vol. 8, no. 4, pp. 1291-1297
G3: Genes|Genomes|Genetics

To function properly, organisms must adjust their physiology, behavior and metabolism in response to a suite of varying environmental conditions. One of the central regulators of these changes is organisms' internal circadian clock, and recent eviden

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid_dedup__::17d26e87dec053a000b91166a5afa21b
https://serval.unil.ch/resource/serval:BIB_BB77B76435C1.P001/REF.pdf

MicroRNA therapeutics: design of single-stranded miR-216b mimics to target KRAS in pancreatic cancer cells

Autor: Raffaella Picco, Jesper Wengel, Giulia Miglietta, Luigi E. Xodo, Stefan Vogel, Annalisa Ferino

Publikováno v: RNA Biology
Ferino, A, Miglietta, G, Picco, R, Vogel, S, Wengel, J & Xodo, L E 2018, ' MicroRNA therapeutics : design of single-stranded miR-216b mimics to target KRAS in pancreatic cancer cells ', RNA Biology, vol. 15, no. 10, pp. 1273-1285 . https://doi.org/10.1080/15476286.2018.1526536

Datasets reporting microRNA expression profiles in normal and cancer cells show that miR-216b is aberrantly downregulated in pancreatic ductal adenocarcinoma (PDAC). We found that KRAS, whose mutant G12D allele drives the pathogenesis of PDAC, is a t

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::cb75f27b37427b2313867442f27a2efe

Identification of miRSNPs associated with the risk of multiple myeloma

Autor: Macauda, Angelica, Calvetti, Diego, Maccari, Giuseppe, Hemminki, Kari, Försti, Asta, Goldschmidt, Hartmut, Weinhold, Niels, Houlston, Richard, Andersen, Vibeke, Vogel, Ulla, Buda, Gabriele, Varkonyi, Judit, Sureda, Anna, Lopez, Joaquin Martinez, Watek, Marzena, Butrym, Aleksandra, Sarasquete, Maria Eugenia, Dudziński, Marek, Jurczyszyn, Artur, Druzd-Sitek, Agnieszka, Kruszewski, Marcin, Subocz, Edyta, Petrini, Mario, Iskierka-Jażdżewska, Elzbieta, Raźny, Malgorzata, Szombath, Gergely, Marques, Herlander, Zawirska, Daria, Chraniuk, Dominik, Halka, Janusz, Hove Jacobsen, Svend Erik, Mazur, Grzegorz, Sanz, Ramón García, Dumontet, Charles, Moreno, Victor, Stępień, Anna, Beider, Katia, Pelosini, Matteo, Reis, Rui Manuel, Krawczyk-Kulis, Malgorzata, Rymko, Marcin, Avet-Loiseau, Hervé, Lesueur, Fabienne, Grząśko, Norbert, Ostrovsky, Olga, Jamroziak, Krzysztof, Vangsted, Annette J, Jerez, Andrés, Tomczak, Waldemar, Zaucha, Jan Maciej, Kadar, Katalin, Pérez, Juan Sainz, Nagler, Arnon, Landi, Stefano, Gemignani, Federica, Canzian, Federico

Publikováno v: Macauda, A, Calvetti, D, Maccari, G, Hemminki, K, Försti, A, Goldschmidt, H, Weinhold, N, Houlston, R, Andersen, V, Vogel, U, Buda, G, Varkonyi, J, Sureda, A, Lopez, J M, Watek, M, Butrym, A, Sarasquete, M E, Dudziński, M, Jurczyszyn, A, Druzd-Sitek, A, Kruszewski, M, Subocz, E, Petrini, M, Iskierka-Jażdżewska, E, Raźny, M, Szombath, G, Marques, H, Zawirska, D, Chraniuk, D, Halka, J, Hove Jacobsen, S E, Mazur, G, Sanz, R G, Dumontet, C, Moreno, V, Stępień, A, Beider, K, Pelosini, M, Reis, R M, Krawczyk-Kulis, M, Rymko, M, Avet-Loiseau, H, Lesueur, F, Grząśko, N, Ostrovsky, O, Jamroziak, K, Vangsted, A J, Jerez, A, Tomczak, W, Zaucha, J M, Kadar, K, Pérez, J S, Nagler, A, Landi, S, Gemignani, F & Canzian, F 2017, ' Identification of miRSNPs associated with the risk of multiple myeloma ', International Journal of Cancer, vol. 140, no. 3, pp. 526-534 . https://doi.org/10.1002/ijc.30465

Multiple myeloma (MM) is a malignancy of plasma cells usually infiltrating the bone marrow, associated with the production of a monoclonal immunoglobulin (M protein) which can be detected in the blood and/or urine. Multiple lines of evidence suggest

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid_dedup__::e2ee1cb768efb2a6387de6fa263e9cad
https://hdl.handle.net/11568/817394

The gene INPPL1, encoding the lipid phosphatase SHIP2, is a candidate for type 2 diabetes in rat and man

Autor: André Bodson, Jens Behrends, G. Servais, Dominique Gauguier, Evelyne Marion, Pamela J. Kaisaki, Daubresse Jc, Claude Szpirer, J. Mockel, Cyril Gueydan, Jonathan C. Levy, Georges Krzentowski, Valérie Pouillon, Stéphane Schurmans, Véronique Kruys

Publikováno v: Scopus-Elsevier
Diabetes, 51

Genetic susceptibility to type 2 diabetes involves many genes, most of which are still unknown. The lipid phosphatase SHIP2 is a potent negative regulator of insulin signaling and sensitivity in vivo and is thus a good candidate gene. Here we report

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3155af37c1761a84281f3d6f79ec25e8
https://ora.ox.ac.uk/objects/uuid:92c3a867-8afa-473e-9daf-ff356eff3896

Post-transcriptional Regulation of Genes Encoding Anti-microbial Peptides in Drosophila

Autor: Véronique Kruys, Laure Twyffels, Aurélien Lauwers, Cyril Gueydan, Romuald Soin, Corinne Wauquier

Publikováno v: The Journal of biological chemistry, 284 (13

Secretion of antimicrobial peptides (AMPep) is a central defense mechanism used by invertebrates to combat infections. In Drosophila the synthesis of these peptides is a highly regulated process allowing their rapid release in the hemolymph upon cont

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2541a4edded8b7adb6016bc8e3d9ad23
https://doi.org/10.1074/jbc.m806778200