Genetic polymorphism in untranslated regions of PRKCZ influences mRNA structure, stability and binding sites.

Autor: Mustafa A; Department of Healthcare BiotechnologyAtta-Ur-Rahman School of Applied Biosciences (ASAB), National University of Sciences and Technology (NUST), Sector H-12, Islamabad, 44000, Pakistan., Shabbir M; Department of Healthcare BiotechnologyAtta-Ur-Rahman School of Applied Biosciences (ASAB), National University of Sciences and Technology (NUST), Sector H-12, Islamabad, 44000, Pakistan. mshabbir@asab.nust.edu.pk., Badshah Y; Department of Healthcare BiotechnologyAtta-Ur-Rahman School of Applied Biosciences (ASAB), National University of Sciences and Technology (NUST), Sector H-12, Islamabad, 44000, Pakistan., Khan K; Cancer Clinical Research Unit, Trials360, Lahore, Pakistan., Abid F; Department of Healthcare BiotechnologyAtta-Ur-Rahman School of Applied Biosciences (ASAB), National University of Sciences and Technology (NUST), Sector H-12, Islamabad, 44000, Pakistan., Trembley JH; Minneapolis VA Health Care System Research Service, Minneapolis, MN, USA.; Department of Laboratory Medicine and Pathology, University of Minnesota, Minneapolis, MN, USA.; Masonic Cancer Center, University of Minnesota, Minneapolis, MN, USA., Afsar T; Department of Community Health Sciences, College of Applied Medical Sciences, King Saud University, Riyadh, Saudi Arabia., Almajwal A; Department of Community Health Sciences, College of Applied Medical Sciences, King Saud University, Riyadh, Saudi Arabia., Razak S; Department of Community Health Sciences, College of Applied Medical Sciences, King Saud University, Riyadh, Saudi Arabia. smarazi@ksu.edu.sa.

Publikováno v: BMC cancer [BMC Cancer] 2024 Sep 13; Vol. 24 (1), pp. 1147. Date of Electronic Publication: 2024 Sep 13.

A 3'UTR-derived small RNA represses pneumolysin synthesis and facilitates pneumococcal brain invasion.

Autor: Shen K; State Key Laboratory of Microbial Resources, Institute of Microbiology, Chinese Academy of Sciences, Beijing, China.; University of Chinese Academy of Sciences, Beijing, China., Miao W; State Key Laboratory of Microbial Resources, Institute of Microbiology, Chinese Academy of Sciences, Beijing, China.; School of Basic Medicine, Shenyang Medical College, Shenyang, China., Zhu L; State Key Laboratory of Microbial Resources, Institute of Microbiology, Chinese Academy of Sciences, Beijing, China.; University of Chinese Academy of Sciences, Beijing, China., Hu Q; State Key Laboratory of Microbial Resources, Institute of Microbiology, Chinese Academy of Sciences, Beijing, China.; University of Chinese Academy of Sciences, Beijing, China., Ren F; School of Basic Medicine, Shenyang Medical College, Shenyang, China., Dong X; State Key Laboratory of Microbial Resources, Institute of Microbiology, Chinese Academy of Sciences, Beijing, China. dongxz@im.ac.cn.; University of Chinese Academy of Sciences, Beijing, China. dongxz@im.ac.cn., Tong H; State Key Laboratory of Microbial Resources, Institute of Microbiology, Chinese Academy of Sciences, Beijing, China. tonghuichun@im.ac.cn.; University of Chinese Academy of Sciences, Beijing, China. tonghuichun@im.ac.cn.

Publikováno v: Communications biology [Commun Biol] 2024 Sep 13; Vol. 7 (1), pp. 1130. Date of Electronic Publication: 2024 Sep 13.

Rli51 Attenuates Transcription of the Listeria Pathogenicity Island 1 Gene mpl and Functions as a Trans -Acting sRNA in Intracellular Bacteria.

Autor: Morón Á; Department of Cell Biology, Facultad de Ciencias Biológicas, Universidad Complutense de Madrid, 28040 Madrid, Spain.; Laboratory of Intracellular Bacterial Pathogens, National Centre for Biotechnology (CNB)-CSIC, 28049 Madrid, Spain., Ortiz-Miravalles L; Laboratory of Intracellular Bacterial Pathogens, National Centre for Biotechnology (CNB)-CSIC, 28049 Madrid, Spain.; Department of Molecular Biology, Universidad Autónoma de Madrid, Centro de Biologia Molecular Severo Ochoa (CBM) CSIC-UAM, 28049 Madrid, Spain., Peñalver M; Laboratory of Intracellular Bacterial Pathogens, National Centre for Biotechnology (CNB)-CSIC, 28049 Madrid, Spain.; Department of Molecular Biology, Universidad Autónoma de Madrid, Centro de Biologia Molecular Severo Ochoa (CBM) CSIC-UAM, 28049 Madrid, Spain., García-Del Portillo F; Laboratory of Intracellular Bacterial Pathogens, National Centre for Biotechnology (CNB)-CSIC, 28049 Madrid, Spain., Pucciarelli MG; Laboratory of Intracellular Bacterial Pathogens, National Centre for Biotechnology (CNB)-CSIC, 28049 Madrid, Spain.; Department of Molecular Biology, Universidad Autónoma de Madrid, Centro de Biologia Molecular Severo Ochoa (CBM) CSIC-UAM, 28049 Madrid, Spain., Ortega AD; Department of Cell Biology, Facultad de Ciencias Biológicas, Universidad Complutense de Madrid, 28040 Madrid, Spain.; Department of Molecular Biology, Universidad Autónoma de Madrid, Centro de Biologia Molecular Severo Ochoa (CBM) CSIC-UAM, 28049 Madrid, Spain.

Publikováno v: International journal of molecular sciences [Int J Mol Sci] 2024 Aug 29; Vol. 25 (17). Date of Electronic Publication: 2024 Aug 29.

Predicting functional UTR variants by integrating region-specific features.

Autor: Li G; State Key Laboratory of Common Mechanism Research for Major Diseases; Center for bioinformatics, National Infrastructures for Translational Medicine, Institute of Clinical Medicine and Peking Union Medical College Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, 1 Shuai Fu Yuan, Dongcheng District, Beijing 100005, China., Wu J; State Key Laboratory of Common Mechanism Research for Major Diseases; Center for bioinformatics, National Infrastructures for Translational Medicine, Institute of Clinical Medicine and Peking Union Medical College Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, 1 Shuai Fu Yuan, Dongcheng District, Beijing 100005, China., Wang X; State Key Laboratory of Common Mechanism Research for Major Diseases; Center for bioinformatics, National Infrastructures for Translational Medicine, Institute of Clinical Medicine and Peking Union Medical College Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, 1 Shuai Fu Yuan, Dongcheng District, Beijing 100005, China.

Publikováno v: Briefings in bioinformatics [Brief Bioinform] 2024 May 23; Vol. 25 (4).

In vivo RNA interactome profiling reveals 3'UTR-processed small RNA targeting a central regulatory hub.

Autor: Liu F; Microbial RNA Systems Biology Unit, Key Laboratory of Molecular Virology and Immunology, Shanghai Institute of Immunity and Infection, Chinese Academy of Sciences, Shanghai, 200031, China.; The Center for Microbes, Development and Health (CMDH), Institut Pasteur of Shanghai, Chinese Academy of Sciences, Shanghai, 200031, China., Chen Z; Microbial RNA Systems Biology Unit, Key Laboratory of Molecular Virology and Immunology, Shanghai Institute of Immunity and Infection, Chinese Academy of Sciences, Shanghai, 200031, China.; Key Laboratory of Medical Molecular Virology (MOE/NHC/CAMS), Shanghai Frontiers Science Center of Pathogenic Microorganisms and Infection, School of Basic Medical Sciences, Shanghai Medical College, Fudan University, Shanghai, 200033, China.; Department of Colorectal Surgery, Fudan University Shanghai Cancer Center & Department of Oncology, Shanghai Medical College, Fudan University, Shanghai, 200032, China., Zhang S; Microbial RNA Systems Biology Unit, Key Laboratory of Molecular Virology and Immunology, Shanghai Institute of Immunity and Infection, Chinese Academy of Sciences, Shanghai, 200031, China.; The Center for Microbes, Development and Health (CMDH), Institut Pasteur of Shanghai, Chinese Academy of Sciences, Shanghai, 200031, China.; University of Chinese Academy of Sciences, Beijing, 100049, China., Wu K; Microbial RNA Systems Biology Unit, Key Laboratory of Molecular Virology and Immunology, Shanghai Institute of Immunity and Infection, Chinese Academy of Sciences, Shanghai, 200031, China.; The Center for Microbes, Development and Health (CMDH), Institut Pasteur of Shanghai, Chinese Academy of Sciences, Shanghai, 200031, China., Bei C; Key Laboratory of Medical Molecular Virology (MOE/NHC/CAMS), Shanghai Frontiers Science Center of Pathogenic Microorganisms and Infection, School of Basic Medical Sciences, Shanghai Medical College, Fudan University, Shanghai, 200033, China., Wang C; Key Laboratory of Medical Molecular Virology (MOE/NHC/CAMS), Shanghai Frontiers Science Center of Pathogenic Microorganisms and Infection, School of Basic Medical Sciences, Shanghai Medical College, Fudan University, Shanghai, 200033, China. chuanwang@fudan.edu.cn., Chao Y; Microbial RNA Systems Biology Unit, Key Laboratory of Molecular Virology and Immunology, Shanghai Institute of Immunity and Infection, Chinese Academy of Sciences, Shanghai, 200031, China. yjchao@ips.ac.cn.; The Center for Microbes, Development and Health (CMDH), Institut Pasteur of Shanghai, Chinese Academy of Sciences, Shanghai, 200031, China. yjchao@ips.ac.cn.; University of Chinese Academy of Sciences, Beijing, 100049, China. yjchao@ips.ac.cn.; Key Laboratory of RNA Science and Engineering, Shanghai Institute of Biochemistry and Cell Biology, Center for Excellence in Molecular Cell Science, Chinese Academy of Sciences, Shanghai, 200031, China. yjchao@ips.ac.cn.

Publikováno v: Nature communications [Nat Commun] 2023 Dec 07; Vol. 14 (1), pp. 8106. Date of Electronic Publication: 2023 Dec 07.