Zobrazeno 1 - 10
of 485
pro vyhledávání: '"Unspecific monooxygenase"'
Autor:
Xuan Zhang, Ren-Xiang Tan, Zhen Zhen Zhou, Hong Jie Zhu, Rui Hua Jiao, Hui Ming Ge, Li Ping Lin
Publikováno v:
Chemical Science. 10:73-82
Polyketide-polyketide hybrids are unique natural products with promising bioactivity, but the hybridization processes remain poorly understood. Herein, we present that the biosynthetic pathways of two immunosuppressants, dalmanol A and acetodalmanol
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::9825430d7b5fa2d35e1d853dad0956e3
https://doi.org/10.1039/c8sc03697g
https://doi.org/10.1039/c8sc03697g
Publikováno v:
Arzneimittelforschung. 52:745-753
Pitavastatin (CAS 147526-32-7, NK-104) is a new and very potent competitive inhibitor of 3-hydroxy-3-methylglutaryl coenzyme A (HMG-CoA) reductase and has been approved for treatment of hyperlipoproteinaemia. Pitavastatin has been studied for its eff
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::d60b73e29de89b07c7fbce6dc5d35cad
https://doi.org/10.1055/s-0031-1299961
https://doi.org/10.1055/s-0031-1299961
Autor:
Mitsuya Nakayama, Seijiro Honma, Takiko Oguro, Kunio Tsukamoto, Satoshi Iwamura, Takemi Yoshida, Satoshi Numazawa, Makoto Sasaki
Publikováno v:
Arzneimittelforschung. 51:651-658
Roxatidine acetate hydrochloride (ROX, 2-acetoxy-N-[3-[m-(1-piperidinylmethyl) phenoxy]propyl] acetamide hydrochloride, CAS 78273-80-0), a histamine 2 (H2) -receptor antagonist, has been clinically applied for the treatment of gastritis, gastric and
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ed869b995ebb7e37f3bdefd4dfefe8c0
https://doi.org/10.1055/s-0031-1300096
https://doi.org/10.1055/s-0031-1300096
Autor:
Shigetoshi Kadota, Suresh Awale, Lidyawati Auw, Takahiro Nobukawa, Kouhei Morikawa, Yasuhiro Tezuka, Feng Li
Publikováno v:
Journal of Natural Products. 74:102-105
From the aqueous extract of the wood of Taxus yunnanensis, which showed cytochrome P450 3A4 (CYP3A4) inhibition, a new isoflavan [(3S,4R)-4'-hydroxy-6,3'-dimethoxyisoflavan-4-ol (1)], a new degraded lignan [2,3-bis(hydroxymethyl)-7-hydroxy-6-methoxy-
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::87a9185fb91a4af06087b7653d65e466
https://doi.org/10.1021/np100665j
https://doi.org/10.1021/np100665j
Publikováno v:
Journal of Pharmacy and Pharmacology. 62:658-662
Objectives The effects of nuciferine, a major active aporphine alkaloid from the leaves of Nelumbo nucifera Gaertn, on a cytochrome P450 1A2 (CYP1A2) probe substrate were investigated in vitro and in vivo. Methods Nuciferine and recombinant human CYP
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4dde1652842f4d051e1483f11882972e
https://doi.org/10.1211/jpp.62.05.0015
https://doi.org/10.1211/jpp.62.05.0015
Autor:
David B. Ball, Daniel J. Edwards, Nick M. Hernandez, Matthew C. Elston, Shin'ichiro Kajiyama, William H. Gerwick, Kazuhiro Irie, Minh U. Huynh
Publikováno v:
Journal of Natural Products. 73:71-74
The P450 cytochrome monooxygenase gene, ltxB, was cloned and overexpressed in Escherichia coli as a 6xHis-tagged protein. The resulting recombinant LtxB was purified by Ni-NTA affinity chromatography and characterized biochemically. Purified LtxB dem
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9f6f472c65bb207c245b33949b3090ac
https://doi.org/10.1021/np900481a
https://doi.org/10.1021/np900481a
Publikováno v:
Journal of Medicinal Chemistry. 52:7315-7318
Agents against biologic stress were designed, containing GABA esterified with lorazepam and amidated with (R)-6-hydroxy-2,5,7,8-tetramethylchroman-2-carboxylic acid (5) or 3,5-di-tert-butyl-4-hydroxybenzoic acid (6). Compounds 5 and 6 inhibited lipid
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0b586ffd6c82ce88f1eba72f5f7e63ff
https://doi.org/10.1021/jm901169b
https://doi.org/10.1021/jm901169b
Autor:
Peter Brust, Steffen Fischer, Eva Grosse Maestrup, Dirk Schepmann, Christian Wiese, Bernhard Wünsch, Achim Hiller, Matthias Scheunemann
Publikováno v:
Bioorganic & Medicinal Chemistry. 17:3630-3641
Several 3H-spiro[[2]benzofuran-1,4'-piperidines] bearing a p-fluorobenzyl residue at the N-atom and various substituents in position 3 of the benzofuran system were synthesized. The crucial reaction steps are the addition of a lithiated benzaldehyde
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::18777f6f140d962d66f582b7c2aea1dc
https://doi.org/10.1016/j.bmc.2009.03.060
https://doi.org/10.1016/j.bmc.2009.03.060
Publikováno v:
Journal of medicinal chemistry, Vol. 52, No 8 (2009) pp. 2192-2195
A method to perform nanoscale automated CYP450-based drug metabolism studies using a capillary as a reaction vessel is described. In-capillary assays consumed only approximately 30 nL of recombinant human CYP450 solution. Ultrafast analysis of substr
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6cb9bc8c409c0e4bbd70e29053241c42
https://doi.org/10.1021/jm900201b
https://doi.org/10.1021/jm900201b
Autor:
Trevor Herbert Yee, Mario A. Shields, Michael J. Sutcliffe, Rupika Delgoda, Simone Badal, Umar Niazi
Publikováno v:
Planta Medica. 75:137-141
Infusions of the plant Picrasma excelsa, known as Jamaican bitterwood tea, are commonly consumed to lower blood sugar levels in diabetics who are already on prescription medicines. We therefore investigated the inhibition properties of this tea again
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::82eea55d6d438885c7edb872749b68f4
https://doi.org/10.1055/s-0028-1088350
https://doi.org/10.1055/s-0028-1088350