Zobrazeno 1 - 10
of 18
pro vyhledávání: '"Unnikrishnan M Chandrasekharan"'
Autor:
Daniel P Harris, Unnikrishnan M Chandrasekharan, Smarajit Bandyopadhyay, Belinda Willard, Paul E DiCorleto
Publikováno v:
PLoS ONE, Vol 11, Iss 2, p e0148905 (2016)
Inflammatory agonists differentially activate gene expression of the chemokine family of proteins in endothelial cells (EC). TNF is a weak inducer of the chemokine CXCL11, while TNF and IFN-γ costimulation results in potent CXCL11 induction. The mol
Externí odkaz:
https://doaj.org/article/2b182b9cd522417a93f795a3dc8b1263
Autor:
Amanda Luu, David J. Odde, Vandana Rai, Rita West, Katarzyna Pogoda, Rajappa S. Kenchappa, Athanassios Dovas, Steven S. Rosenfeld, Paul A. Janmey, Thomas T. Egelhoff, Peter Canoll, Unnikrishnan M. Chandrasekharan, James F. Crish, Jan Lammerding, Hannah S. Picariello, Emily Bell, Mariah McMahon
Publikováno v:
Proceedings of the National Academy of Sciences. 116:15550-15559
The ability of glioblastoma to disperse through the brain contributes to its lethality, and blocking this behavior has been an appealing therapeutic approach. Although a number of proinvasive signaling pathways are active in glioblastoma, many are re
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4c35f9d710596cc5a599663008b36c53
https://doi.org/10.1073/pnas.1902847116
https://doi.org/10.1073/pnas.1902847116
Autor:
Unnikrishnan M. Chandrasekharan, Raminderjit Kaur, Jennifer E. Harvey, Chad Braley, Vandana Rai, MacKenzie Lee, Nicholas de Windt, Jason Hsieh, Ritika Jaini, Defne Bayik, Rachel G. Scheraga, Anthony P. Fernandez, Paul E. DiCorleto, M. Elaine Husni
Publikováno v:
Journal of Investigative Dermatology. 142:2159-2172.e9
TNF-α, a proinflammatory cytokine, is a crucial mediator of psoriasis pathogenesis. TNF-α functions by activating TNFR1 and TNFR2. Anti-TNF drugs that neutralize TNF-α, thus blocking the activation of TNFR1 and TNFR2, have been proven highly thera
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8daa0cb7de2316f52fe096b8016881df
https://doi.org/10.1016/j.jid.2021.12.036
https://doi.org/10.1016/j.jid.2021.12.036
Autor:
W.H. Wilson Tang, Unnikrishnan M. Chandrasekharan, Stanley L. Hazen, Yuping Wu, Sihe Wang, M. Elaine Husni, Zeneng Wang
Publikováno v:
Arthritis Research & Therapy, Vol 20, Iss 1, Pp 1-12 (2018)
Arthritis Research & Therapy
Arthritis Research & Therapy
Background Rheumatoid arthritis (RA) patients are at high risk of developing cardiovascular disease (CVD). In RA, chronic inflammation may lead to endothelial dysfunction, an early indicator of CVD, owing to diminished nitric oxide (NO) production. B
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::fe4215487316900b2b62d6b390aaacc2
http://link.springer.com/article/10.1186/s13075-018-1616-x
http://link.springer.com/article/10.1186/s13075-018-1616-x
Autor:
Julia Lax, Jennifer Harvey, M. Elaine Husni, Michael Tytell, Paul E. DiCorleto, Unnikrishnan M. Chandrasekharan, Federico G. Seifarth
Psoriasis is a chronic inflammatory skin disease with systemic manifestations and potential genetic etiology. The newest treatments utilize antibodies against one of several cytokines known to underlie the inflammatory signaling molecules that produc
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c0478c65ea91a33180c5da4a34ef6cd6
https://europepmc.org/articles/PMC6111098/
https://europepmc.org/articles/PMC6111098/
Autor:
M. Elaine Husni, Stanley A Hazen, Wai Hong Tang, Michael Lucke, Unnikrishnan M. Chandrasekharan, Danielle M. Brennan
Publikováno v:
Arthritisrheumatology (Hoboken, N.J.). 70(8)
OBJECTIVE To compare the activity of high-density lipoprotein (HDL)-associated paraoxonase 1 (PON1) in patients with psoriasis (PsO) and patients with psoriatic arthritis (PsA), and to evaluate the association of PON1 activity with the extent of dise
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b48d2875b30e52ead05ff6faf0a8afcc
https://pubmed.ncbi.nlm.nih.gov/29569857
https://pubmed.ncbi.nlm.nih.gov/29569857
Autor:
Unnikrishnan M. Chandrasekharan, Rebecca Bartlett, Emily G. Tillmaand, Paul E. DiCorleto, Joel D. Boerckel, Matthew S. Waitkus
Publikováno v:
Arteriosclerosis, Thrombosis, and Vascular Biology. 34:1020-1031
Objective— Angiogenesis is the formation of new blood vessels through endothelial cell sprouting. This process requires the mitogen-activated protein kinases, signaling molecules that are negatively regulated by the mitogen-activated protein kinase
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::7bf38a8265cc50c90122d8f994d17ab3
https://doi.org/10.1161/atvbaha.114.303403
https://doi.org/10.1161/atvbaha.114.303403
Autor:
Unnikrishnan M. Chandrasekharan, Paul E. DiCorleto, Elizabeth E Martelli, Sathyamangla V. Naga Prasad, Neelakantan T Vasudevan, Arthur M. Feldman, Yilu Qin, Manveen K Gupta, David Young, Subha Sen, Afshan K. Hussain, Maradumane L. Mohan, Gerald W. Dorn
Publikováno v:
Circulation. 128:377-387
Background— Proinflammatory cytokine tumor necrosis factor-α (TNFα) induces β-adrenergic receptor (βAR) desensitization, but mechanisms proximal to the receptor in contributing to cardiac dysfunction are not known. Methods and Results— Two di
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::4c1b24faeb454593e86f6ef7056533dc
https://doi.org/10.1161/circulationaha.113.003183
https://doi.org/10.1161/circulationaha.113.003183
Publikováno v:
Seminars in celldevelopmental biology. 62
The synovium constitutes the envelope of articular joints and is a critical provider of synovial fluid components and articular cartilage nutrients. Its inflammation is a predominant feature and cause of joint degeneration in diseases as diverse as r
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a1205b90a53ad1ab12e2d87a079625b0
https://pubmed.ncbi.nlm.nih.gov/27212252
https://pubmed.ncbi.nlm.nih.gov/27212252
Autor:
Juhua Chen, Eric J. Topol, Edward F. Plow, Tatiana V. Byzova, Paul E. DiCorleto, Natalya V. Narizhneva, Eugene A. Podrez, Unnikrishnan M. Chandrasekharan, Olga V. Razorenova
Publikováno v:
The FASEB Journal. 19:1158-1160
Expression of cell adhesion molecules (CAM) responsible for leukocyte-endothelium interactions plays a crucial role in inflammation and atherogenesis. Up-regulation of vascular CAM-1 (VCAM-1), intracellular CAM-1 (ICAM-1), and E-selectin expression p
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::35be26e05f0cf57854ca7a3b4531616d
https://doi.org/10.1096/fj.04-3310fje
https://doi.org/10.1096/fj.04-3310fje