Zobrazeno 1 - 10
of 16
pro vyhledávání: '"Unni Tengvall"'
Publikováno v:
Pharmaceutics, Vol 14, Iss 3, p 635 (2022)
The published article [...]
Externí odkaz:
https://doaj.org/article/ae023e2ed92f43e2b2ed1d789749a06d
Autor:
Elisa Toropainen, Sara J. Fraser-Miller, Dunja Novakovic, Eva M. Del Amo, Kati-Sisko Vellonen, Marika Ruponen, Tapani Viitala, Ossi Korhonen, Seppo Auriola, Laura Hellinen, Mika Reinisalo, Unni Tengvall, Stephanie Choi, Mohammad Absar, Clare Strachan, Arto Urtti
Publikováno v:
Pharmaceutics, Vol 13, Iss 4, p 452 (2021)
Eye drops of poorly soluble drugs are frequently formulated as suspensions. Bioavailability of suspended drug depends on the retention and dissolution of drug particles in the tear fluid, but these factors are still poorly understood. We investigated
Externí odkaz:
https://doaj.org/article/2af1e0b88b534519bb185694d6e37fe4
Publikováno v:
Pharmaceutics, Vol 11, Iss 8, p 412 (2019)
Retinal pigment epithelium (RPE) acts as an outer blood−retinal barrier that limits the access of circulating xenobiotics to the eye. In addition, the RPE limits posterior elimination of intravitreally injected drugs to circulation. Thus, permeatio
Externí odkaz:
https://doaj.org/article/cd4a1eeeb6884dafa2025a683c22efe2
Autor:
Pasi Kallio, Arto Urtti, Samu Hemmilä, Marika Ruponen, Elisa Toropainen, Unni Tengvall-Unadike
Publikováno v:
Slas Technology
This paper presents a novel microflow-based concept for studying the permeability of in vitro cell models or ex vivo tissues. Using the proposed concept, we demonstrate how to maintain physiologically relevant test conditions and produce highly repro
Autor:
Mohammad Absar, Mika Reinisalo, Arto Urtti, Clare J. Strachan, Laura Hellinen, Eva M. del Amo, Stephanie Choi, Unni Tengvall, Kati-Sisko Vellonen, Seppo Auriola, Elisa Toropainen, Sara J. Fraser-Miller, Marika Ruponen, Ossi Korhonen, Dunja Novakovic, Tapani Viitala
Publikováno v:
Pharmaceutics
Volume 13
Issue 4
Pharmaceutics, Vol 13, Iss 452, p 452 (2021)
Volume 13
Issue 4
Pharmaceutics, Vol 13, Iss 452, p 452 (2021)
Eye drops of poorly soluble drugs are frequently formulated as suspensions. Bioavailability of suspended drug depends on the retention and dissolution of drug particles in the tear fluid, but these factors are still poorly understood. We investigated
Autor:
Mika Reinisalo, Arto Urtti, Laura Pelkonen, Eva M. del Amo, Heidi Kidron, Unni Tengvall-Unadike, Marika Ruponen
Publikováno v:
European Journal of Pharmaceutical Sciences. 109:162-168
Melanin pigment is a negatively charged polymer found in pigmented human tissues. In the eye, iris, ciliary body, choroid and retinal pigment epithelium (RPE) are heavily pigmented. Several drug molecules are known to bind to melanin, but larger sets
Autor:
Marika Ruponen, Eva M. del Amo, Elisa Toropainen, Veli-Pekka Ranta, Eva Ramsay, Arto Urtti, Unni Tengvall-Unadike
Publikováno v:
Ramsay, E, Del Amo, E M, Toropainen, E, Tengvall-Unadike, U, Ranta, V-P, Urtti, A & Ruponen, M 2018, ' Corneal and conjunctival drug permeability : Systematic comparison and pharmacokinetic impact in the eye ', European journal of pharmaceutical sciences : official journal of the European Federation for Pharmaceutical Sciences, vol. 119, pp. 83-89 . https://doi.org/10.1016/j.ejps.2018.03.034
On the surface of the eye, both the cornea and conjunctiva are restricting ocular absorption of topically applied drugs, but barrier contributions of these two membranes have not been systemically compared. Herein, we studied permeability of 32 small
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::fb2b291bc712eb64f9f2b1adbaf807c2
https://doi.org/10.1016/j.ejps.2018.03.034
https://doi.org/10.1016/j.ejps.2018.03.034
Autor:
Elisa Toropainen, Marjo Tuomainen, Unni Tengvall, Seppo Auriola, Arto Urtti, Marika Ruponen, Théo Picardat, Eva Ramsay, Eva M. del Amo
Publikováno v:
Journal of pharmaceutical sciences. 106(9)
Conjunctiva occupies most of the ocular surface area, and conjunctival permeability affects ocular and systemic drug absorption of topical ocular medications. Therefore, the aim of this study was to obtain a computational in silico model for structur
Autor:
Kaisa Ketomäki, Harri Lönnberg, Piia Penttinen, Elena Azhayeva, Tuula Tennilä, Unni Tengvall, Alex Azhayev, Seppo Auriola
Publikováno v:
Chemistry & Biodiversity. 1:609-625
The synthesis of disulfide-cross-linked circular oligonucleotides, employing two different approaches, was accomplished. Several circular oligomers, which bear a C(5)-aminoalkyl-tethered thymidine unit, were labeled with photoluminescent europium(III
Publikováno v:
Journal of Pharmaceutical and Biomedical Analysis. 32:581-590
Covalent post-synthesis or solid-phase conjugation of peptides to oligonucleotides has been reported as a possible method of delivering antisense oligonucleotides into cells. While synthesis strategies for preparing these conjugates have been widely