Zobrazeno 1 - 10
of 27
pro vyhledávání: '"Unmesha Thanekar"'
Autor:
Julie Osborn, Reena Mourya, Unmesha Thanekar, Weizhe Su, Lin Fei, Pranavkumar Shivakumar, Jorge A. Bezerra
Publikováno v:
Hepatology Communications, Vol 6, Iss 5, Pp 995-1004 (2022)
Children with biliary atresia (BA) often develop portal hypertension (PHT) and its complications, which are associated with high morbidity and mortality. The goal of this study was to identify serum biomarkers of PHT by using large‐scale proteomics
Externí odkaz:
https://doaj.org/article/8902c9dcdb374a04873e11b2f0fcda7f
Autor:
Jai Junbae Jee, Li Yang, Pranavkumar Shivakumar, Pei-pei Xu, Reena Mourya, Unmesha Thanekar, Pu Yu, Yu Zhu, Yongkang Pan, Haibin Wang, Xufei Duan, Yongqin Ye, Bin Wang, Zhu Jin, Yuanmei Liu, Zhiqing Cao, Miki Watanabe-Chailland, Lindsey E. Romick-Rosendale, Michael Wagner, Lin Fei, Zhenhua Luo, Nicholas J. Ollberding, Shao-tao Tang, Jorge A. Bezerra
Publikováno v:
Nature Communications, Vol 13, Iss 1, Pp 1-15 (2022)
The pathogenesis of biliary atresia remains poorly understood. Here, the authors report that maternal butyrate treatment alters the gut microbiome and glutamine/hypoxanthine metabolites similar to human subjects, and suppresses biliary atresia in new
Externí odkaz:
https://doaj.org/article/f8ba779a49e84d54b38c7a365e7df194
Autor:
Nikhil Hebbar, Rebecca Epperly, Abishek Vaidya, Unmesha Thanekar, Sarah E. Moore, Masayuki Umeda, Jing Ma, Sagar L. Patil, Deanna Langfitt, Sujuan Huang, Cheng Cheng, Jeffery M. Klco, Stephen Gottschalk, M. Paulina Velasquez
Publikováno v:
Nature Communications, Vol 13, Iss 1, Pp 1-14 (2022)
There is an unmet need to discover suitable targets for CAR-T therapy in patients with acute myeloid leukemia (AML). Here the authors show that GRP78, a key regulator of the unfolded protein response, is highly expressed on the surface of primary AML
Externí odkaz:
https://doaj.org/article/72831edc14f84b8e8310483eae0dcae9
Autor:
Abishek Vaidya, Erin Doherty, Xiya Wu, Sujuan Huang, Nikhil Hebbar, Unmesha Thanekar, Challice L. Bonifant, Cheng Cheng, Stephen Gottschalk, M. Paulina Velasquez
Publikováno v:
Haematologica, Vol 108, Iss 4 (2022)
The outcome of patients with acute myeloid leukemia remains poor, and immunotherapy has the potential to improve this. T cells expressing chimeric antigen receptors or bispecific T-cell engagers targeting CD123 are actively being explored in preclini
Externí odkaz:
https://doaj.org/article/8bab277d181c4b0c91404e2eaa6688b6
Autor:
Astha Malik, Unmesha Thanekar, Surya Amarachintha, Reena Mourya, Shreya Nalluri, Alexander Bondoc, Pranavkumar Shivakumar
Publikováno v:
Frontiers in Oncology, Vol 10 (2021)
Hepatocellular carcinoma (HCC) is the most common primary malignancy of the liver and a leading cause of death in the US and worldwide. HCC remains a global health problem and is highly aggressive with unfavorable prognosis. Even with surgical interv
Externí odkaz:
https://doaj.org/article/b6afafcdbd614ed3a613938a56aef9f0
Autor:
Laale F. Alawi, Sanjeev Dhakal, Sana E. Emberesh, Harshal Sawant, Anhar Hosawi, Unmesha Thanekar, Nadja Grobe, Khalid M. Elased
Publikováno v:
Frontiers in Pharmacology, Vol 11 (2021)
Activation of the renin angiotensin system plays a pivotal role in the regulation of blood pressure, which is mainly attributed to the formation of angiotensin-II (Ang II). The actions of Ang II are mediated through binding to the Ang-II type 1 recep
Externí odkaz:
https://doaj.org/article/c4c61e369b11431d992d2795fc66a172
Autor:
Xiaofeng Li, Surya Amarachintha, Li Yang, Zhenhua Luo, Hiroaki Ayabe, Reena Mourya, Unmesha Thanekar, Pranavkumar Shivakumar, Jorge A. Bezerra
Publikováno v:
Hepatology
BACKGROUND AND AIMS: Biliary atresia is a severe inflammatory and fibrosing cholangiopathy of neonates of unknown etiology. The onset of cholestasis at birth implies a prenatal onset of liver dysfunction. Our aim was to investigate the mechanisms lin
Autor:
Nikhil Hebbar, Jorge Ibanez, Unmesha Thanekar, Zhongzhen Yi, Haley Houke, Giedre Krenciute, M. Paulina Velasquez
Publikováno v:
SSRN Electronic Journal.
Autor:
Julie Osborn, Reena Mourya, Unmesha Thanekar, Weizhe Su, Lin Fei, Pranavkumar Shivakumar, Jorge A. Bezerra
Publikováno v:
Hepatology communications. 6(5)
Children with biliary atresia (BA) often develop portal hypertension (PHT) and its complications, which are associated with high morbidity and mortality. The goal of this study was to identify serum biomarkers of PHT by using large-scale proteomics.
Autor:
Nikhil Hebbar, Rebecca Epperly, Abishek Vaidya, Unmesha Thanekar, Sarah E. Moore, Masayuki Umeda, Jing Ma, Sagar L. Patil, Deanna Langfitt, Sujuan Huang, Cheng Cheng, Jeffery M. Klco, Stephen Gottschalk, M. Paulina Velasquez
Publikováno v:
Nature Communications
Nature Communications, Vol 13, Iss 1, Pp 1-14 (2022)
Nature Communications, Vol 13, Iss 1, Pp 1-14 (2022)
Developing CAR T cells for acute myeloid leukemia (AML) has been hampered by a paucity of targets that are expressed on AML blasts and not on hematopoietic progenitor cells (HPCs). Here we demonstrate that GRP78 is expressed on the cell surface of pr