Zobrazeno 1 - 6
of 6
pro vyhledávání: '"Unmesh, Shah"'
Autor:
Gregory L, Adams, Francisco, Velazquez, Charles, Jayne, Unmesh, Shah, Shouwu, Miao, Eric R, Ashley, Maria, Madeira, Taro E, Akiyama, Jerry, Di Salvo, Takao, Suzuki, Nengxue, Wang, Quang, Truong, Eric, Gilbert, Dan, Zhou, Andreas, Verras, Melissa, Kirkland, Michele, Pachanski, Maryann, Powles, Wu, Yin, Feroze, Ujjainwalla, Srikanth, Venkatraman, Scott D, Edmondson
Publikováno v:
ACS medicinal chemistry letters. 8(1)
GPR120 (FFAR4) is a fatty acid sensing G protein coupled receptor (GPCR) that has been identified as a target for possible treatment of type 2 diabetes. A selective activator of GPR120 containing a chromane scaffold has been designed, synthesized, an
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::b516664a4a45395b9f909635d7176636
https://pubmed.ncbi.nlm.nih.gov/28105282
https://pubmed.ncbi.nlm.nih.gov/28105282
Autor:
Samuel Chackalamannil, Shiyong Wang, Leyla Arik, Craig D. Boyle, Carolyn Foster, Ying Zhai, Lindo Neil A, Kwokei Ng, Bernard R. Neustadt, Angela Monopoli, Unmesh Shah, William J. Greenlee, Jean E. Lachowicz
Publikováno v:
Bioorganic & Medicinal Chemistry Letters. 18:4199-4203
SCH 58261 is a reported adenosine A2A receptor antagonist, which is active in rat in vivo models of Parkinson’s Disease upon ip administration. However, it has poor selectivity versus the A1 receptor and does not demonstrate oral activity. We repor
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a859e35b89ed5aacd26db4e0ce642dee
https://doi.org/10.1016/j.bmcl.2008.05.074
https://doi.org/10.1016/j.bmcl.2008.05.074
Autor:
Claire M. Lankin, Geoffrey B. Varty, Samuel Chackalamannil, William J. Greenlee, Kwokei Ng, Guy A. Higgins, Mary Cohen-Williams, Craig D. Boyle, Unmesh Shah, Jean E. Lachowicz, Hongtao Zhang, Bernard R. Neustadt
Publikováno v:
Bioorganic & Medicinal Chemistry Letters. 18:4204-4209
SCH 58261 is a reported adenosine A(2A) receptor antagonist which is active in rat in vivo models of Parkinson's Disease upon ip administration. However, it has poor selectivity versus the A(1) receptor and does not demonstrate oral activity. Quinoli
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8884c1a785846e5fdd554e8de630ee69
https://doi.org/10.1016/j.bmcl.2008.05.069
https://doi.org/10.1016/j.bmcl.2008.05.069
Autor:
Unmesh, Shah, Timothy J, Kowalski
Publikováno v:
Vitamins and hormones. 84
Type 2 diabetes (T2D) has reached epidemic proportions, and there is an unmet medical need for orally effective agents that regulate glucose homeostasis. GPR119, a class-A (rhodopsin-like) G protein-coupled receptor expressed primarily in the pancrea
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::87605489b3dfed7548b21ac706e5af25
https://pubmed.ncbi.nlm.nih.gov/21094910
https://pubmed.ncbi.nlm.nih.gov/21094910
Autor:
Unmesh, Shah, Robert, Hodgson
Publikováno v:
Current opinion in drug discoverydevelopment. 13(4)
Antagonism of the adenosine A2A receptor has emerged as a promising non-dopaminergic approach for the potential treatment of Parkinson's disease (PD). Several pharmaceutical and academic institutions have ongoing research programs in this area, and o
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::225fb207478a877beb2e4f3e12597b40
https://pubmed.ncbi.nlm.nih.gov/20597030
https://pubmed.ncbi.nlm.nih.gov/20597030
Autor:
A. K. Ganguly, Andrew McPhail, Sergei Kolotuchin, Samuel Chackalamannil, Unmesh Shah, and Alexei Buevich, Chelliah Mariappan
Publikováno v:
Journal of the American Chemical Society. 128(39)
The first total synthesis of (−)-himgaline and a highly enantioselective synthesis of its congener (−)-GB 13 are described. Decarboxylative aza-Michael reaction of the hexacyclic lactone precursor under acidic conditions, followed by basic workup
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::489d6a308fe773898838d471ff573d93
https://pubmed.ncbi.nlm.nih.gov/17002352
https://pubmed.ncbi.nlm.nih.gov/17002352