Výsledky vyhledávání - "Unkel, Steffen"

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On the Addams family of discrete frailty distributions for modelling multivariate case I interval-censored data

Autor: Bardo, Maximilian, Hens, Niel, Unkel, Steffen

Random effect models for time-to-event data, also known as frailty models, provide a conceptually appealing way of quantifying association between survival times and of representing heterogeneities resulting from factors which may be difficult or imp

Externí odkaz: http://arxiv.org/abs/2406.00804

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The shape of the relative frailty variance induced by discrete random effect distributions in univariate and multivariate survival models

Autor: Bardo, Maximilian, Unkel, Steffen

In statistical models for the analysis of time-to-event data, individual heterogeneity is usually accounted for by means of one or more random effects, also known as frailties. In the vast majority of the literature, the random effect is assumed to f

Externí odkaz: http://arxiv.org/abs/2303.04915

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On estimands and the analysis of adverse events in the presence of varying follow-up times within the benefit assessment of therapies

Autor: Unkel, Steffen, Amiri, Marjan, Benda, Norbert, Beyersmann, Jan, Knoerzer, Dietrich, Kupas, Katrin, Langer, Frank, Leverkus, Friedhelm, Loos, Anja, Ose, Claudia, Proctor, Tanja, Schmoor, Claudia, Schwenke, Carsten, Skipka, Guido, Unnebrink, Kristina, Voss, Florian, Friede, Tim

The analysis of adverse events (AEs) is a key component in the assessment of a drug's safety profile. Inappropriate analysis methods may result in misleading conclusions about a therapy's safety and consequently its benefit-risk ratio. The statistica

Externí odkaz: http://arxiv.org/abs/1805.01834

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Systematic reviews in paediatric multiple sclerosis and Creutzfeldt-Jakob disease exemplify shortcomings in methods used to evaluate therapies in rare conditions

Autor: Unkel, Steffen, Röver, Christian, Stallard, Nigel, Benda, Norbert, Posch, Martin, Zohar, Sarah, Friede, Tim

Publikováno v: Orphanet Journal of Rare Diseases, 11:16, 2016

BACKGROUND: Randomized controlled trials (RCTs) are the gold standard design of clinical research to assess interventions. However, RCTs cannot always be applied for practical or ethical reasons. To investigate the current practices in rare diseases,

Externí odkaz: http://arxiv.org/abs/1602.07207

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