Zobrazeno 1 - 10
of 11
pro vyhledávání: '"Unja Martin"'
Autor:
Michael Certo, Christopher Baldeviano, Sharlene Adams, Martin Asimis, Alexander Astrakhan, Andy Chavkin, Maria L. Cabral, Jimmy Chu, Marie Debrue, Devina Desai, John Evans, Pinky Htun, Amanda Iniguez, Jordan Jarjour, Carl Johnson, Harini Kantamneni, Sema Kurtulus, Michael Magee, Unja Martin, Seamus McKenney, Sara Miller, Prashant Nambiar, Vinh Khang Nguyen, Mauris Nnamani, Jen Obrigewitch, Lisa Pechilis, Molly Perkins, Christopher Petersen, Jason Pinger, Cindy Rogers, Nick Rouillard, Kendal Sanson, Emily Thompson, Collin Walter, Roslyn Yi, Sarah Voytek, Philip Gregory
Publikováno v:
Cancer Research. 82:581-581
Anti-CD19 CAR T cell therapies have improved outcomes for non-Hodgkin lymphoma (NHL) patients. However, only 30-40% of patients treated with commercially available CART cell therapies obtain long term remission, highlighting the need for more efficac
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::ba36a88532fbaad33195924bbae866ba
https://doi.org/10.1158/1538-7445.am2022-581
https://doi.org/10.1158/1538-7445.am2022-581
Autor:
Danielle Montt, Rachael Logan, Timmer John C, Mark Pogson, Jordan Jarjour, Claudya Evandy, Jones Kyle S, Giacomo Tampella, Quennie Vong, Anne-Rachael Krostag, Joshua A. Gustafson, Dong Xia, Alexander Astrakhan, Kaori Oda, Bryan Peguero, Wai-Hang Leung, Jacob Appelbaum, Brendan Eckelman, Joy Zhang, Michael C. Jensen, James B. Rottman, Unja Martin
Publikováno v:
Regular and young investigator award abstracts.
Background Bioengineered T cell treatments for acute myeloid leukemia (AML) are challenged by near universal expression of leukemia antigens on normal hematopoietic stem/progenitor cells:1 2 ‘on target/off tumor‘ activity may cause myelosuppressi
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::bd9b30ec14c4c65c5a6644d257d5a68e
https://doi.org/10.1136/jitc-2020-sitc2020.0100
https://doi.org/10.1136/jitc-2020-sitc2020.0100
Autor:
Jacob S. Appelbaum, April Price, Joy Zhang, Kaori Oda, Sumati Sundaram, Paula Lewis, Sanela Bilic, Giacomo Tampella, Dong Xia, Anne-Rachel Krostag, Pauline So, Unja Martin, Wai-Hang Leung, Alexander Astrakhan, Mark Pogson, Jordan Jarjour, Josh Gustafson, Michael CV Jensen
Publikováno v:
Blood. 138:905-905
Background: Acute myeloid leukemia (AML) chimeric antigen receptor (CAR) T cell therapies are at early stages of testing in human clinical trials. We previously described the design of a CD33-specific dimerizing agent regulated immunoreceptor complex
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::864213b7b710c4cbb0ef5a26b422c948
https://doi.org/10.1182/blood-2021-154461
https://doi.org/10.1182/blood-2021-154461
Autor:
Wai-Hang Leung, Joel Gay, Unja Martin, Tracy E. Garrett, Holly M. Horton, Michael T. Certo, Bruce R. Blazar, Richard A. Morgan, Philip D. Gregory, Jordan Jarjour, Alexander Astrakhan
Publikováno v:
JCI insight. 5
Chimeric antigen receptor (CAR) T cell therapies have achieved promising outcomes in several cancers, however more challenging oncology indications may necessitate advanced antigen receptor designs and functions. Here we describe a bipartite receptor
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::cedc649bdff2af6633dae81cecbe75a5
https://pubmed.ncbi.nlm.nih.gov/31039141
https://pubmed.ncbi.nlm.nih.gov/31039141
Autor:
Nicholas A Popp, Alexandra E. Grier, Unja Martin, Kyle Jacoby, Julia G. Yang, Stephen Burleigh, Michael C. Jensen, Andrew M. Scharenberg, Michelle C Krutein, Kamila S. Gwiazda, Jaya Sahni, David J. Rawlings, Iram F. Khan
Many future therapeutic applications of Clustered Regularly Interspaced Short Palindromic Repeats (CRISPR)/Cas9 and related RNA-guided nucleases are likely to require their use to promote gene targeting, thus necessitating development of methods that
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::980de1f2fa3c70eba0b91ff7585a9386
https://europepmc.org/articles/PMC5113096/
https://europepmc.org/articles/PMC5113096/
Autor:
Shannon Grande, Kathryn Hooper, Yegor Smurnyy, Andrew Chavkin, Ankit Gupta, Richard A. Morgan, Unja Martin, Michael S Magee, Jordan Jarjour, Lisa J Pechilis, Amanda Rode, Anne-Rachel Krostag, Kyle Havens, Alexander Astrakhan
Publikováno v:
Blood. 132:338-338
Chimeric antigen receptor (CAR) T cell therapies continue to show excellent outcomes in hematological cancers. Achieving success in additional tumor indications, however, will likely require modulating inhibitory pathways that limit CAR T cell potenc
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::b6e306c046254916ba7da6e04d4d89dc
https://doi.org/10.1182/blood-2018-99-119247
https://doi.org/10.1182/blood-2018-99-119247
Autor:
David A. Largaespada, Brian C. Gliniak, Philip J. Morrissey, John E. Sims, Neal G. Copeland, Unja Martin, Werner Müller, Andrew G. Farr, James P. Di Santo, Raymond J. Paxton, Nancy A. Jenkins, Kirsten E. Garka, Linda S. Park, Steven F. Ziegler
Publikováno v:
The Journal of Experimental Medicine
The cellular receptor for murine thymic stromal lymphopoietin (TSLP) was detected in a variety of murine, but not human myelomonocytic cell lines by radioligand binding. cDNA clones encoding the receptor were isolated from a murine T helper cell cDNA
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::dabec0fed6509b692ea0dde73872d8c7
http://europepmc.org/articles/PMC2193276
http://europepmc.org/articles/PMC2193276
Autor:
Sean Luhr, David Cosman, Linda S. Park, Philip J. Morrissey, Larsen Alf D, Unja Martin, Rick Sorensen
Publikováno v:
Proceedings of the National Academy of Sciences. 89:4295-4299
A cDNA clone (clone 71) that encodes a low-affinity receptor for murine granulocyte-macrophage colony-stimulating factor (GM-CSF) has been isolated by direct expression. This molecule is the homologue of the human GM-CSF receptor alpha subunit, altho
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5dc64a385ebee17d9893b3de268d8f23
https://doi.org/10.1073/pnas.89.10.4295
https://doi.org/10.1073/pnas.89.10.4295
Autor:
Unja Martin, Jesse L. Gurgel, Christopher A. Gabel, Scholler John, Blair R. Renshaw, John E. Sims
Publikováno v:
Journal of immunology (Baltimore, Md. : 1950). 183(6)
An interesting trait shared by many members of the IL-1 cytokine family is the absence of a signal sequence that can direct the newly synthesized polypeptides to the endoplasmic reticulum. As a result, these cytokines accumulate intracellularly. Rece
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::547c4a3e068442d8a83fc0b51179eac5
https://pubmed.ncbi.nlm.nih.gov/19717513
https://pubmed.ncbi.nlm.nih.gov/19717513
Publikováno v:
The Journal of Immunology. 182:38.10-38.10
Interleukin (IL)-1F6, like many members of the IL-1 cytokine family, lacks a signal sequence. Moreover, IL-1F6 does not contain an obvious prodomain or a caspase cleavage site but is somehow released to act on target cells. The mechanism of cellular
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::1d2403aa97348573bdea9db52448c753
https://doi.org/10.4049/jimmunol.182.supp.38.10
https://doi.org/10.4049/jimmunol.182.supp.38.10