Inflammation status modulates the effect of host genetic variation on intestinal gene expression in inflammatory bowel disease.

Autor: Hu S; Department of Gastroenterology and Hepatology, University of Groningen and University Medical Center Groningen, Groningen, The Netherlands.; Department of Genetics, University of Groningen and University Medical Center Groningen, Groningen, The Netherlands., Uniken Venema WT; Department of Gastroenterology and Hepatology, University of Groningen and University Medical Center Groningen, Groningen, The Netherlands.; Department of Genetics, University of Groningen and University Medical Center Groningen, Groningen, The Netherlands., Westra HJ; Department of Genetics, University of Groningen and University Medical Center Groningen, Groningen, The Netherlands., Vich Vila A; Department of Gastroenterology and Hepatology, University of Groningen and University Medical Center Groningen, Groningen, The Netherlands.; Department of Genetics, University of Groningen and University Medical Center Groningen, Groningen, The Netherlands., Barbieri R; Department of Gastroenterology and Hepatology, University of Groningen and University Medical Center Groningen, Groningen, The Netherlands.; Department of Genetics, University of Groningen and University Medical Center Groningen, Groningen, The Netherlands., Voskuil MD; Department of Gastroenterology and Hepatology, University of Groningen and University Medical Center Groningen, Groningen, The Netherlands., Blokzijl T; Department of Gastroenterology and Hepatology, University of Groningen and University Medical Center Groningen, Groningen, The Netherlands., Jansen BH; Department of Gastroenterology and Hepatology, University of Groningen and University Medical Center Groningen, Groningen, The Netherlands., Li Y; Department of Gastroenterology and Hepatology, University of Groningen and University Medical Center Groningen, Groningen, The Netherlands.; Department of Genetics, University of Groningen and University Medical Center Groningen, Groningen, The Netherlands., Daly MJ; Broad Institute of Harvard and Massachusetts Institute of Technology, Cambridge, MA, USA.; Institute for Molecular Medicine Finland, HiLIFE, University of Helsinki, Helsinki, Finland., Xavier RJ; Broad Institute of Harvard and Massachusetts Institute of Technology, Cambridge, MA, USA.; Center for Microbiome Informatics and Therapeutic, Massachusetts Institute of Technology, Cambridge, MA, USA., Dijkstra G; Department of Gastroenterology and Hepatology, University of Groningen and University Medical Center Groningen, Groningen, The Netherlands., Festen EA; Department of Gastroenterology and Hepatology, University of Groningen and University Medical Center Groningen, Groningen, The Netherlands.; Department of Genetics, University of Groningen and University Medical Center Groningen, Groningen, The Netherlands., Weersma RK; Department of Gastroenterology and Hepatology, University of Groningen and University Medical Center Groningen, Groningen, The Netherlands. r.k.weersma@umcg.nl.

Publikováno v: Nature communications [Nat Commun] 2021 Feb 18; Vol. 12 (1), pp. 1122. Date of Electronic Publication: 2021 Feb 18.

Single-Cell RNA Sequencing of Blood and Ileal T Cells From Patients With Crohn's Disease Reveals Tissue-Specific Characteristics and Drug Targets.

Autor: Uniken Venema WT; Department of Gastroenterology and Hepatology, University of Groningen, University Medical Center Groningen, Groningen, The Netherlands., Voskuil MD; Department of Gastroenterology and Hepatology, University of Groningen, University Medical Center Groningen, Groningen, The Netherlands., Vila AV; Department of Gastroenterology and Hepatology, University of Groningen, University Medical Center Groningen, Groningen, The Netherlands; Department of Genetics, University of Groningen, University Medical Center Groningen, Groningen, The Netherlands., van der Vries G; Department of Genetics, University of Groningen, University Medical Center Groningen, Groningen, The Netherlands., Jansen BH; Department of Gastroenterology and Hepatology, University of Groningen, University Medical Center Groningen, Groningen, The Netherlands., Jabri B; Department of Medicine and Committee on Immunology, University of Chicago, Chicago, Illinois., Faber KN; Department of Gastroenterology and Hepatology, University of Groningen, University Medical Center Groningen, Groningen, The Netherlands; Department of Laboratory Medicine, University of Groningen, University Medical Center Groningen, Groningen, The Netherlands., Dijkstra G; Department of Gastroenterology and Hepatology, University of Groningen, University Medical Center Groningen, Groningen, The Netherlands., Xavier RJ; Broad Institute of Harvard and the Massachusetts Institute of Technology, Cambridge, Massachusetts; Division of Gastroenterology, Massachusetts General Hospital, Harvard Medical School, Boston, Massachusetts., Wijmenga C; Department of Genetics, University of Groningen, University Medical Center Groningen, Groningen, The Netherlands., Graham DB; Broad Institute of Harvard and the Massachusetts Institute of Technology, Cambridge, Massachusetts; Division of Gastroenterology, Massachusetts General Hospital, Harvard Medical School, Boston, Massachusetts., Weersma RK; Department of Gastroenterology and Hepatology, University of Groningen, University Medical Center Groningen, Groningen, The Netherlands., Festen EA; Department of Gastroenterology and Hepatology, University of Groningen, University Medical Center Groningen, Groningen, The Netherlands; Department of Genetics, University of Groningen, University Medical Center Groningen, Groningen, The Netherlands. Electronic address: e.a.m.festen@umcg.nl.

Publikováno v: Gastroenterology [Gastroenterology] 2019 Feb; Vol. 156 (3), pp. 812-815.e22. Date of Electronic Publication: 2018 Nov 02.