New Approaches to Overcome Transport Related Drug Resistance in Trypanosomatid Parasites

Autor: Garcia-Salcedo, Jose A, Unciti-Broceta, Juan D, Valverde-Pozo, Javier, Soriano, Miguel

Leishmania and Trypanosoma are members of the Trypanosomatidae family that cause severe human infections such as leishmaniasis, Chagas disease, and sleeping sickness affecting millions of people worldwide. Despite efforts to eradicate them, migration

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=od______2636::ebb2ba1c25951f54fad1b272c5a1b923
https://hdl.handle.net/10668/2523

Agathadiol, a labdane diterpenoid from juniper berries, is a positive allosteric modulator of CB 1 R.

Autor: Salamone S; Dipartimento di Scienze del Farmaco, Largo Donegani 2, 28100 Novara, Italy., Appendino G; Dipartimento di Scienze del Farmaco, Largo Donegani 2, 28100 Novara, Italy., Khalili A; Dipartimento di Scienze del Farmaco, Largo Donegani 2, 28100 Novara, Italy., Pollastro F; Dipartimento di Scienze del Farmaco, Largo Donegani 2, 28100 Novara, Italy; PlantaChem Srls, via Amico Canobio 4/6, 28100 Novara, Italy. Electronic address: federica.pollastro@uniupo.it., Munoz E; Instituto Maimónides de Investigación Biomédica de Córdoba, av. de Menéndez Pidal, 14004 Córdoba, Spain; Departamento de Biología Celular, Fisiología e Inmunología, Campus de Menéndez Pidal, Universidad de Córdoba, 14071 Spain Córdoba, Spain; Hospital Universitario Reina Sofía, av. de Menéndez Pidal, s/n, 14004 Córdoba, Spain. Electronic address: fi1muble@uco.es., Unciti-Broceta JD; Emerald Health Biotechnology, Parque Científico Tecnológico Rabanales 21, Calle Cecilia Payne, 14014 Córdoba, Spain.

Publikováno v: Fitoterapia [Fitoterapia] 2021 Nov; Vol. 155, pp. 105059. Date of Electronic Publication: 2021 Oct 09.

(+)-trans-Cannabidiol-2-hydroxy pentyl is a dual CB 1 R antagonist/CB 2 R agonist that prevents diabetic nephropathy in mice.

Autor: González-Mariscal I; Instituto de Investigación Biomédica de Málaga-IBIMA, UGC Endocrinología y Nutrición, Hospital Regional Universitario de Málaga, 29009 Málaga, Spain. Electronic address: isabel.gonzalez@ibima.eu., Carmona-Hidalgo B; Emerald Health Biotechnology, Córdoba, Spain., Winkler M; Symrise AG, Holzminden, Germany., Unciti-Broceta JD; Emerald Health Biotechnology, Córdoba, Spain., Escamilla A; Microscopy platform, IBIMA, Malaga, Spain., Gómez-Cañas M; Departamento de Bioquímica y Biología Molecular, Facultad de Medicina, Instituto Universitario de Investigación en Neuroquímica, Universidad Complutense, CIBERNED and IRYCIS, Madrid, Spain., Fernández-Ruiz J; Departamento de Bioquímica y Biología Molecular, Facultad de Medicina, Instituto Universitario de Investigación en Neuroquímica, Universidad Complutense, CIBERNED and IRYCIS, Madrid, Spain., Fiebich BL; VivaCell Biotechnology GmbH, Dezlingen, Germany., Romero-Zerbo SY; Instituto de Investigación Biomédica de Málaga-IBIMA, UGC Endocrinología y Nutrición, Hospital Regional Universitario de Málaga, 29009 Málaga, Spain., Bermúdez-Silva FJ; Instituto de Investigación Biomédica de Málaga-IBIMA, UGC Endocrinología y Nutrición, Hospital Regional Universitario de Málaga, 29009 Málaga, Spain; Centro de Investigación Biomédica en Red de Diabetes y Enfermedades Metabólicas Asociadas (CIBERDEM), Madrid, Spain., Collado JA; Instituto Maimónides de Investigación Biomédica de Córdoba, Spain; Departamento de Biología Celular, Fisiología e Inmunología, Universidad de Córdoba, 14004 Córdoba, Spain; Hospital Universitario Reina Sofía, Córdoba, Spain., Muñoz E; Instituto Maimónides de Investigación Biomédica de Córdoba, Spain; Departamento de Biología Celular, Fisiología e Inmunología, Universidad de Córdoba, 14004 Córdoba, Spain; Hospital Universitario Reina Sofía, Córdoba, Spain. Electronic address: fi1muble@uco.es.

Publikováno v: Pharmacological research [Pharmacol Res] 2021 Jul; Vol. 169, pp. 105492. Date of Electronic Publication: 2021 May 19.

An effective polymeric nanocarrier that allows for active targeting and selective drug delivery in cell coculture systems.

Autor: Cano-Cortes MV; GENYO, Centre for Genomics and Oncological Research, Pfizer/University of Granada/Andalusian Regional Government, PTS Granada, Avda. Ilustración 114, 18016 Granada, Spain. rmsanchez@go.ugr.es juandiaz@go.ugr.es and Department of Medicinal & Organic Chemistry and Excellence Research Unit of 'Chemistry applied to Biomedicine and the Environment', Faculty of Pharmacy, University of Granada, Campus de Cartuja s/n, 18071, Granada, Spain and Biosanitary Research Institute of Granada (ibs.GRANADA), University Hospitals of Granada-University of Granada, Granada, 18071, Spain., Altea-Manzano P; GENYO, Centre for Genomics and Oncological Research, Pfizer/University of Granada/Andalusian Regional Government, PTS Granada, Avda. Ilustración 114, 18016 Granada, Spain. rmsanchez@go.ugr.es juandiaz@go.ugr.es and Laboratory of Cellular Metabolism and Metabolic Regulation, VIB-KU Leuven Center for Cancer Biology, Campus GasthuisberǵHerestraat 49, 3000 Leuven, Belgium., Laz-Ruiz JA; GENYO, Centre for Genomics and Oncological Research, Pfizer/University of Granada/Andalusian Regional Government, PTS Granada, Avda. Ilustración 114, 18016 Granada, Spain. rmsanchez@go.ugr.es juandiaz@go.ugr.es and Department of Medicinal & Organic Chemistry and Excellence Research Unit of 'Chemistry applied to Biomedicine and the Environment', Faculty of Pharmacy, University of Granada, Campus de Cartuja s/n, 18071, Granada, Spain and Biosanitary Research Institute of Granada (ibs.GRANADA), University Hospitals of Granada-University of Granada, Granada, 18071, Spain., Unciti-Broceta JD; Nanogetic S.L. Avda de la Innovacion 1, PTS, Edificio BIC, 18016 - Granada, Spain., Lopez-Delgado FJ; GENYO, Centre for Genomics and Oncological Research, Pfizer/University of Granada/Andalusian Regional Government, PTS Granada, Avda. Ilustración 114, 18016 Granada, Spain. rmsanchez@go.ugr.es juandiaz@go.ugr.es and DestiNA Genomica S.L. PTS Granada, Avenida de la Innovación 1, Edificio BIC, 18016, Granada, Spain., Espejo-Roman JM; GENYO, Centre for Genomics and Oncological Research, Pfizer/University of Granada/Andalusian Regional Government, PTS Granada, Avda. Ilustración 114, 18016 Granada, Spain. rmsanchez@go.ugr.es juandiaz@go.ugr.es and Department of Medicinal & Organic Chemistry and Excellence Research Unit of 'Chemistry applied to Biomedicine and the Environment', Faculty of Pharmacy, University of Granada, Campus de Cartuja s/n, 18071, Granada, Spain and Biosanitary Research Institute of Granada (ibs.GRANADA), University Hospitals of Granada-University of Granada, Granada, 18071, Spain., Diaz-Mochon JJ; GENYO, Centre for Genomics and Oncological Research, Pfizer/University of Granada/Andalusian Regional Government, PTS Granada, Avda. Ilustración 114, 18016 Granada, Spain. rmsanchez@go.ugr.es juandiaz@go.ugr.es and Department of Medicinal & Organic Chemistry and Excellence Research Unit of 'Chemistry applied to Biomedicine and the Environment', Faculty of Pharmacy, University of Granada, Campus de Cartuja s/n, 18071, Granada, Spain and Biosanitary Research Institute of Granada (ibs.GRANADA), University Hospitals of Granada-University of Granada, Granada, 18071, Spain., Sanchez-Martin RM; GENYO, Centre for Genomics and Oncological Research, Pfizer/University of Granada/Andalusian Regional Government, PTS Granada, Avda. Ilustración 114, 18016 Granada, Spain. rmsanchez@go.ugr.es juandiaz@go.ugr.es and Department of Medicinal & Organic Chemistry and Excellence Research Unit of 'Chemistry applied to Biomedicine and the Environment', Faculty of Pharmacy, University of Granada, Campus de Cartuja s/n, 18071, Granada, Spain and Biosanitary Research Institute of Granada (ibs.GRANADA), University Hospitals of Granada-University of Granada, Granada, 18071, Spain.

Publikováno v: Nanoscale [Nanoscale] 2021 Feb 18; Vol. 13 (6), pp. 3500-3511.

The dimerization of Δ ⁹ -tetrahydrocannabinolic acid A (THCA-A).

Autor: Cuadari A; Dipartimento di Scienze del Farmaco, Università del Piemonte Orientale, Novara 28100, Italy., Pollastro F; Dipartimento di Scienze del Farmaco, Università del Piemonte Orientale, Novara 28100, Italy., Unciti-Broceta JD; Emerald Health Biotechnology España, Calle Cecilia Payne, Córdoba 14014, Spain., Caprioglio D; Dipartimento di Scienze del Farmaco, Università del Piemonte Orientale, Novara 28100, Italy., Minassi A; Dipartimento di Scienze del Farmaco, Università del Piemonte Orientale, Novara 28100, Italy., Lopatriello A; Dipartimento di Farmacia, Università di Napoli Federico II, Napoli 80131, Italy., Muñoz E; Maimonides Biomedical Research Institute of Córdoba, Cordoba 14004, Spain.; Department of Cellular Biology, Physiology and Immunology, University of Córdoba, Cordoba 14004, Spain.; University Hospital Reina Sofía, Avenida de Menendez Pidal s/n, Cordoba 14004, Spain., Taglialatela-Scafati O; Dipartimento di Farmacia, Università di Napoli Federico II, Napoli 80131, Italy., Appendino G; Dipartimento di Scienze del Farmaco, Università del Piemonte Orientale, Novara 28100, Italy.

Publikováno v: Acta pharmaceutica Sinica. B [Acta Pharm Sin B] 2019 Sep; Vol. 9 (5), pp. 1078-1083. Date of Electronic Publication: 2019 Jun 24.