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Oxone promoted dehydrogenative Povarov cyclization of N-aryl glycine derivatives: an approach towards quinoline fused lactones and lactams

Autor: Murugan Muthukrishnan, Devidas A. More, Ganesh H. Shinde, Aslam C. Shaikh

Publikováno v: RSC Advances. 9:30277-30291

Oxone promoted intramolecular dehydrogenative imino Diels–Alder reaction (Povarov cyclization) of alkyne tethered N-aryl glycine esters and amides has been explored, thus affording biologically significant quinoline fused lactones and lactams. The

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::04a471c0dd92debe3db603358d02ca39
https://doi.org/10.1039/c9ra06212b

Submerged fermentation of Streptomyces uncialis providing a biotechnology platform for uncialamycin biosynthesis, engineering, and production

Autor: Dong Yang, Jun Luo, Tingting Huang, Ajeeth Adhikari, Christiana N. Teijaro, Hindra Hindra, Hui Ming Ge, Xiaohui Yan, Ben Shen

Publikováno v: Journal of Industrial Microbiology & Biotechnology

Uncialamycin (UCM) belongs to the anthraquinone-fused subfamily of 10-membered enediyne natural products that exhibits an extraordinary cytotoxicity against a wide spectrum of human cancer cell lines. Antibody-drug conjugates, utilizing synthetic ana

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8bc7745b5ccffd355e5d9d7dd4ff6d0b
http://europepmc.org/articles/PMC8210685

Review – Lichen-Associated Bacteria as a Hot Spot of Chemodiversity: Focus on Uncialamycin, a Promising Compound for Future Medicinal Applications

Autor: Martin Grube, Nathalie Legrave, David Delmail, Marcelino T. Suzuki, Delphine Parrot, Sophie Tomasi

Publikováno v: Planta Medica
Planta Medica, Georg Thieme Verlag, 2016, 82 (13), pp.1143-1152. ⟨10.1055/s-0042-105571⟩
Planta Medica, 2016, 82 (13), pp.1143-1152. ⟨10.1055/s-0042-105571⟩

International audience; This review presents the state of knowledge on the medicinal potential of bacteria associated with lichens. In fact, besides the classical symbiotic partners (photobiont and mycobiont) forming the lichen thallus, associated ba

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9c03ba6c13d475794f0723f0eda59a67
https://doi.org/10.1055/s-0042-105571

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