Zobrazeno 1 - 10
of 13
pro vyhledávání: '"Una Nattermann"'
Autor:
Joaquin Caro-Astorga, Joseph T. Meyerowitz, Devon A. Stork, Una Nattermann, Samantha Piszkiewicz, Lara Vimercati, Petra Schwendner, Antoine Hocher, Charles Cockell, Erika DeBenedictis
Publikováno v:
Frontiers in Microbiology, Vol 15 (2024)
Nature exhibits an enormous diversity of organisms that thrive in extreme environments. From snow algae that reproduce at sub-zero temperatures to radiotrophic fungi that thrive in nuclear radiation at Chernobyl, extreme organisms raise many question
Externí odkaz:
https://doaj.org/article/40f727a8d0054ceb950106a4fff3deb9
Autor:
Yang Hsia, Rubul Mout, William Sheffler, Natasha I. Edman, Ivan Vulovic, Young-Jun Park, Rachel L. Redler, Matthew J. Bick, Asim K. Bera, Alexis Courbet, Alex Kang, T. J. Brunette, Una Nattermann, Evelyn Tsai, Ayesha Saleem, Cameron M. Chow, Damian Ekiert, Gira Bhabha, David Veesler, David Baker
Publikováno v:
Nature Communications, Vol 12, Iss 1, Pp 1-10 (2021)
De novo design of self-assembling protein nanostructures and materials is of significant interest, however design of complex, multi-component assemblies is challenging. Here, the authors present a stepwise hierarchical approach to build such assembli
Externí odkaz:
https://doaj.org/article/8bb80e33cedb4e58856a97a798a217fd
Autor:
Zhe Li, Shunzhi Wang, Una Nattermann, Asim K. Bera, Andrew J. Borst, Matthew J. Bick, Erin C. Yang, William Sheffler, Byeongdu Lee, Soenke Seifert, Hannah Nguyen, Alex Kang, Radhika Dalal, Joshua M. Lubner, Yang Hsia, Hugh Haddox, Alexis Courbet, Quinton Dowling, Marcos Miranda, Andrew Favor, Ali Etemadi, Natasha I. Edman, Wei Yang, Banumathi Sankaran, Babak Negahdari, David Baker
SummaryProtein crystallization plays a central role in structural biology1, with broad impact2in pharmaceutical formulation3, drug delivery4, biosensing5, and biocatalysis6,7. Despite this importance, the process of protein crystallization remains po
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::97c9e49b9bf954ca7ba67cff48a16384
https://doi.org/10.1101/2022.11.18.517014
https://doi.org/10.1101/2022.11.18.517014
Autor:
Jing Yang (John) Wang, Alena Khmelinskaia, William Sheffler, Marcos C. Miranda, Aleksandar Antanasijevic, Andrew J. Borst, Susana V. Torres, Chelsea Shu, Yang Hsia, Una Nattermann, Daniel Ellis, Carl Walkey, Maggie Ahlrichs, Sidney Chan, Alex Kang, Hannah Nguyen, Claire Sydeman, Banumathi Sankaran, Mengyu Wu, Asim K. Bera, Lauren Carter, Brooke Fiala, Michael Murphy, David Baker, Andrew B. Ward, Neil P. King
Computationally designed protein nanoparticles have recently emerged as a promising platform for the development of new vaccines and biologics. For many applications, secretion of designed nanoparticles from eukaryotic cells would be advantageous, bu
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::115c7abbdfb14cb721d89bac11eda22f
https://doi.org/10.1101/2022.08.04.502842
https://doi.org/10.1101/2022.08.04.502842
Autor:
Joel Quispe, David Veesler, Philip Bradley, Scott E. Boyken, David Baker, Una Nattermann, William Sheffler, D. Nagarajan, George Ueda, Alexis Courbet, Young-Jun Park, Justin M. Kollman, J. P. Hansen, Bethel Np, Daniel-Adriano Silva, Adam Moyer, Chunfu Xu, Yang Hsia, Neil P. King
Natural nanomachines like the F1/F0-ATPase contain protein components that undergo rotation relative to each other. Designing such mechanically constrained nanoscale protein architectures with internal degrees of freedom is an outstanding challenge f
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::d1980c347129ed6f10ca632fa616b536
https://doi.org/10.1101/2021.11.11.468255
https://doi.org/10.1101/2021.11.11.468255
Autor:
Ivan Vulovic, Cameron M. Chow, Natasha I. Edman, Evelyn Tsai, Yang Hsia, Matthew J. Bick, Alex Kang, Alexis Courbet, William Sheffler, Rubul Mout, Gira Bhabha, Rachel L. Redler, Young-Jun Park, David Veesler, David Baker, Una Nattermann, Damian C. Ekiert, Ayesha Saleem, Asim K. Bera, T. J. Brunette
Publikováno v:
Nature Communications
Nature Communications, Vol 12, Iss 1, Pp 1-10 (2021)
Nature Communications, Vol 12, Iss 1, Pp 1-10 (2021)
A systematic and robust approach to generating complex protein nanomaterials would have broad utility. We develop a hierarchical approach to designing multi-component protein assemblies from two classes of modular building blocks: designed helical re
Autor:
Yang Hsia, Rubul Mout, William Sheffler, Natasha I. Edman, Ivan Vulovic, Young-Jun Park, Rachel L. Redler, Matthew J. Bick, Asim K. Bera, Alexis Courbet, Alex Kang, TJ Brunette, Una Nattermann, Evelyn Tsai, Ayesha Saleem, Cameron M. Chow, Damian Ekiert, Gira Bhabha, David Veesler, David Baker
A goal of de novo protein design is to develop a systematic and robust approach to generating complex nanomaterials from stable building blocks. Due to their structural regularity and simplicity, a wide range of monomeric repeat proteins and oligomer
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::91df8f7682a2a4422e94cd3226ea4762
https://doi.org/10.1101/2020.07.27.221333
https://doi.org/10.1101/2020.07.27.221333
Gatekeeper helix activates Golgi SM protein Sly1 and directly mediates close-range vesicle tethering
Autor:
B. M. Delgado, Rachael L. Plemel, Joji Mima, Una Nattermann, Mengtong Duan, Elizabeth A. Miller, Alexey J. Merz, Daniel P. Nickerson, T. Takenaka, A. Lin
The essential Golgi protein Sly1 is a member of the SM (Sec1/mammalian Unc-18) family of SNARE chaperones. Sly1 was originally identified through gain-of-function alleles that bypass requirements for diverse vesicle tethering factors. Employing genet
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::59a634574df040a47f697b8a5d5d9717
Autor:
Rachel U. Park, David Baker, Una Nattermann, Kevin A Cannon, Scott E. Boyken, Neil P. King, Todd O. Yeates, Sue Yi
Publikováno v:
Protein Sci
In recent years, new protein engineering methods have produced more than a dozen symmetric, self‐assembling protein cages whose structures have been validated to match their design models with near‐atomic accuracy. However, many protein cage desi
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f072aecc993f9beed2f48ae6e5febf6a
https://europepmc.org/articles/PMC7096701/
https://europepmc.org/articles/PMC7096701/
Autor:
Suzie H. Pun, Heather H. Gustafson, Neil P. King, Rashmi Ravichandran, Garreck H. Lenz, Marc J. Lajoie, David Baker, Una Nattermann, Angelica Yehdego, Jacob B. Bale, Daniel Ellis, Sharon Ke, Drew L. Sellers, Gabriel Butterfield
Publikováno v:
Nature. 552:415-420
Computationally designed icosahedral protein-based assemblies can protect their genetic material and evolve in biochemical environments, suggesting a route to the custom design of synthetic nanomaterials for non-viral drug delivery. Viruses use capsi