Zobrazeno 1 - 10
of 30
pro vyhledávání: '"Una Campbell"'
Autor:
Francesca Perini, Jadwiga Maria Nazimek, Shane Mckie, Liliana P. Capitão, Jessica Scaife, Deepa Pal, Michael Browning, Gerard R. Dawson, Hiroyuki Nishikawa, Una Campbell, Seth C. Hopkins, Antony Loebel, Rebecca Elliott, Catherine J. Harmer, Bill Deakin, Kenneth S. Koblan
Publikováno v:
Schizophrenia, Vol 9, Iss 1, Pp 1-11 (2023)
Abstract Ulotaront, a trace amine-associated receptor 1 (TAAR1) and serotonin 5-HT1A receptor agonist without antagonist activity at dopamine D2 or the serotonin 5-HT2A receptors, has demonstrated efficacy in the treatment of schizophrenia. Here we r
Externí odkaz:
https://doaj.org/article/8e93de31cac74e1c866d57bdd55e4b8e
Publikováno v:
Biomedicine & Pharmacotherapy, Vol 153, Iss , Pp 113359- (2022)
Inhibitors of dopamine transporters (DAT), norepinephrine transporters (NET) and serotonin transporters (SERT) are effective treatments for neuropsychiatric diseases. Dasotraline [(1R,4 S)− 4-(3,4-dichlorophenyl)− 1,2,3,4-tetrahydro-1-naphthalena
Externí odkaz:
https://doaj.org/article/afb181bcb2324c0ab10ca6a081e286fb
Autor:
Colleen Synan, Carrie Bowen, David J. Heal, Christelle Froger-Colléaux, Patrick M. Beardsley, Nina Dedic, Seth C. Hopkins, Una Campbell, Kenneth S. Koblan
Publikováno v:
Drug and alcohol dependence. 231
Ulotaront (SEP-363856) is a trace amine-associated receptor 1 (TAAR1) agonist with 5-hydroxytryptamine type 1A (5-HT1A) agonist activity that is currently in Phase 3 clinical development for the treatment of schizophrenia. Unlike available antipsycho
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1238e8ec35eeb6be0573e7ce6a77c632
https://pubmed.ncbi.nlm.nih.gov/35033729
https://pubmed.ncbi.nlm.nih.gov/35033729
Autor:
Una Campbell, Kerry L. Spear, Taleen Hanania, Seth C. Hopkins, Liming Shao, John Emmerson Campbell, Emer Leahy, Philip Jones, Nina Dedic, Kenneth S. Koblan, Thomas H. Large, Robert Lew
Publikováno v:
Journal of Pharmacology and Experimental Therapeutics. 371:1-14
For the past 50 years, the clinical efficacy of antipsychotic medications has relied on blockade of dopamine D2 receptors. Drug development of non-D2 compounds, seeking to avoid the limiting side effects of dopamine receptor blockade, has failed to d
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::2808a2c8f936f84a6ad2fd06dc5207ea
https://doi.org/10.1124/jpet.119.260281
https://doi.org/10.1124/jpet.119.260281
Autor:
Q. Kevin Fang, John Emmerson Campbell, Una Campbell, Philip Jones, Noel Aaron Powell, Vadim Alexandrov, Emily Sabath, Liming Shao, Kerry L. Spear, Irene Morganstern, Thomas H. Large, Taleen Hanania, Hua M. Zhong
Publikováno v:
MedChemComm. 7:1093-1101
Phenotypic drug discovery (PDD) is increasingly being recognized as a viable compliment to target-based drug discovery (TDD). By measuring functional changes, typically at a systems level, PDD can facilitate the identification of compounds having a d
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::fe09535f97f43c9fa55f35e30eca47e3
https://doi.org/10.1039/c6md00128a
https://doi.org/10.1039/c6md00128a
Autor:
Michael C. Hewitt, Larry W. Hardy, Una Campbell, Liming Shao, Scott Christopher Malcolm, Mark A. Varney, Zhi-Dong Jiang, Fengjiang Wang, Kerry L. Spear, Sharon Rae Engel, Rudy Schreiber, Nancy A. Spicer, Jianguo Ma
Publikováno v:
Journal of Medicinal Chemistry. 54:5283-5295
The present work expands the chemical space known to offer potent inhibition of the serotonin transporter (SERT), norepinephrine transporter (NET), and dopamine transporter (DAT) and discloses novel bicyclic octahydrocyclopenta[c]pyrrole and octahydr
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::aed0afc224aeeeca77078f581960d256
https://doi.org/10.1021/jm101312a
https://doi.org/10.1021/jm101312a
Autor:
Sharon Rae Engel, Larry W. Hardy, Michael C. Hewitt, Kerry L. Spear, John Emmerson Campbell, Rudy Schreiber, Liming Shao, Jianguo Ma, Una Campbell, Fengjiang Wang, Nancy A. Spicer, Scott Christopher Malcolm, Mark A. Varney
Publikováno v:
Bioorganic & Medicinal Chemistry Letters. 21:1438-1441
Novel chiral cyclohexylaryl amines were developed with potent reuptake inhibition against the serotonin, norepinephrine and dopamine transporters and activity at 10 and 30 mpk PO in the mouse tail suspension test. Prototype compound 31 (SERT, NET, DA
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7042369b79aee5fac51b2c9ee2e85dad
https://doi.org/10.1016/j.bmcl.2011.01.016
https://doi.org/10.1016/j.bmcl.2011.01.016
Autor:
R. Schreiber, Megan E. Breuer, Lucianne Groenink, S.M. Korte, Una Campbell, Marcel D. Waldinger, Johnny S.W. Chan, Eelke M.S. Snoeren, Taleen Hanania, Ronald S. Oosting, Berend Olivier
Publikováno v:
European Neuropsychopharmacology. 18:908-916
Current antidepressants have a delayed onset of action and disturbing side effects, including inhibition of sexual behavior. It is hypothesized that novel drugs, hitting multiple disease-relevant targets, may yield a new generation of superior antide
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::65e7b51d4716265c0a94ee9c167ad28a
https://doi.org/10.1016/j.euroneuro.2008.07.011
https://doi.org/10.1016/j.euroneuro.2008.07.011
Autor:
Dana E. Rodriguez, Jean-Michel Vernier, Hutchinson John H, Hervé Schaffhauser, Anthony B. Pinkerton, Lorrie P. Daggett, Joyce K. James, Michael F. Gardner, Blake A. Rowe, Una Campbell, Rowena V. Cube
Publikováno v:
Bioorganic & Medicinal Chemistry Letters. 15:1565-1571
We have identified and synthesized a series of phenyl-tetrazolyl and 4-thiopyridyl indanones as allosteric potentiators of the metabotropic glutamate receptor 2. Structure activity relationship studies directed toward improving the potency and level
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a8e1edf523edbd2b8328be76da134078
https://doi.org/10.1016/j.bmcl.2005.01.077
https://doi.org/10.1016/j.bmcl.2005.01.077
Autor:
Laura E. Chavez-Noriega, P. Jeffrey Conn, Hervé Schaffhauser, Michael J. Marino, Una Campbell
Publikováno v:
Current Neuropharmacology. 3:9-34
Schizophrenia is the most disabling psychiatric disorder and one of the world's top ten causes of long-term disability, affecting 1% of the population worldwide. The major symptoms of schizophrenia , psychosis (positive symptoms), apathy, social with
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::bba7985c965e1b8f6aed26d3b567e155
https://doi.org/10.2174/1570159052773369
https://doi.org/10.2174/1570159052773369