Zobrazeno 1 - 10
of 111
pro vyhledávání: '"Una, O'Doherty"'
Publikováno v:
Pathogens and Immunity, Vol 8, Iss 2 (2024)
Background: The primary hurdle to curing HIV is due to the establishment of a reservoir early in infection. In an effort to find new treatment strategies, we and others have focused on understanding the selection pressures exerted on the reservoir by
Externí odkaz:
https://doaj.org/article/1daacb0028114ff39505fc2386e9139f
Publikováno v:
Pathogens and Immunity, Vol 8, Iss 1 (2023)
The inaugural FASEB HIV Reservoirs and Immune Control Conference brought researchers together from across the globe to discuss reservoir dynamics in clinical cohorts. It extended over 4 days in the seaside town of Malahide, Ireland. The scientific se
Externí odkaz:
https://doaj.org/article/d0eb302487b14973a85a09382e436e05
Autor:
Marilia R. Pinzone, Sam Weissman, Alexander O. Pasternak, Ryan Zurakowski, Stephen Migueles, Una O’Doherty
Publikováno v:
JCI Insight, Vol 6, Iss 16 (2021)
Historically, naive cells have been considered inconsequential to HIV persistence. Here, we compared the contributions of naive and memory cells to the reservoirs of individuals with a spectrum of reservoir sizes and variable immunological control. W
Externí odkaz:
https://doaj.org/article/07e18e798f2e4473be66cf7c80da6216
Autor:
Marilia Rita Pinzone, D. Jake VanBelzen, Sam Weissman, Maria Paola Bertuccio, LaMont Cannon, Emmanuele Venanzi-Rullo, Stephen Migueles, R. Brad Jones, Talia Mota, Sarah B. Joseph, Kevin Groen, Alexander O. Pasternak, Wei-Ting Hwang, Brad Sherman, Anastasios Vourekas, Giuseppe Nunnari, Una O’Doherty
Publikováno v:
Nature Communications, Vol 10, Iss 1, Pp 1-12 (2019)
How HIV reservoirs are shaped over time on antiviral therapy is poorly understood. Here, the authors analyze the dynamics of the HIV reservoir by longitudinal proviral sequencing revealing that HIV reservoir expression can contribute to its clearance
Externí odkaz:
https://doaj.org/article/bcf0eb263eba47799a2cae2421234886
Autor:
Emmanuele Venanzi Rullo, Marilia Rita Pinzone, LaMont Cannon, Sam Weissman, Manuela Ceccarelli, Ryan Zurakowski, Giuseppe Nunnari, Una O’Doherty
Publikováno v:
JCI Insight, Vol 5, Iss 20 (2020)
Despite the efficacy of antiretroviral therapy (ART), HIV persists in a latent form and remains a hurdle to eradication. CD4+ T lymphocytes harbor the majority of the HIV reservoir, but the role of individual subsets remains unclear. CD4+ T cells wer
Externí odkaz:
https://doaj.org/article/3420deeaca514f978eefbad384131d6d
Autor:
Leila B. Giron, Florent Colomb, Emmanouil Papasavvas, Livio Azzoni, Xiangfan Yin, Matthew Fair, Alitzel Anzurez, Mohammad Damra, Karam Mounzer, Jay R. Kostman, Pablo Tebas, Una O'Doherty, Hiroaki Tateno, Qin Liu, Michael R. Betts, Luis J. Montaner, Mohamed Abdel-Mohsen
Publikováno v:
EBioMedicine, Vol 59, Iss , Pp 102945- (2020)
Background: A comprehensive understanding of host factors modulated by the antiviral cytokine interferon-α (IFNα) is imperative for harnessing its beneficial effects while avoiding its detrimental side-effects during HIV infection. Cytokines modula
Externí odkaz:
https://doaj.org/article/fab31996f60c46fa9d6c34db3d611550
Publikováno v:
Retrovirology, Vol 15, Iss 1, Pp 1-15 (2018)
Abstract Recent years have seen a substantial increase in the number of tools available to monitor and study HIV reservoirs. Here, we discuss recent technological advances that enable an understanding of reservoir dynamics beyond classical assays to
Externí odkaz:
https://doaj.org/article/472a3536401449f4b19e79adc4187aab
Autor:
Marilia Rita Pinzone, Una O’Doherty
Publikováno v:
Retrovirology, Vol 15, Iss 1, Pp 1-12 (2018)
Abstract The identification of the most appropriate marker to measure reservoir size has been a great challenge for the HIV field. Quantitative viral outgrowth assay (QVOA), the reference standard to quantify the amount of replication-competent virus
Externí odkaz:
https://doaj.org/article/986fde13cbff4b148038cdf6d18cd5be
Autor:
Maud Mavigner, S. Thera Lee, Jakob Habib, Cameron Robinson, Guido Silvestri, Una O’Doherty, Ann Chahroudi
Publikováno v:
Journal of Virus Eradication, Vol 2, Iss 4, Pp 219-226 (2016)
Objectives: Although antiretroviral therapy (ART) effectively suppresses HIV-1 replication, it does not eradicate the virus and ART interruption consistently results in rebound of viraemia, demonstrating the persistence of a long-lived viral reservoi
Externí odkaz:
https://doaj.org/article/51612f8cd7e04f7fa4f1b52e329bb19f
Autor:
Saba Ghassemi, Joseph S. Durgin, Selene Nunez-Cruz, Jai Patel, John Leferovich, Marilia Pinzone, Feng Shen, Katherine D. Cummins, Gabriela Plesa, Vito Adrian Cantu, Shantan Reddy, Frederic D. Bushman, Saar I. Gill, Una O’Doherty, Roddy S. O’Connor, Michael C. Milone
Publikováno v:
Nature Biomedical Engineering. 6:118-128
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::26077ffdf79d07acc01efe40bd25c3b5
https://doi.org/10.1038/s41551-021-00842-6
https://doi.org/10.1038/s41551-021-00842-6