Zobrazeno 1 - 10
of 27
pro vyhledávání: '"Un Yung Choi"'
Lung-specific MCEMP1 functions as an adaptor for KIT to promote SCF-mediated mast cell proliferation
Autor:
Youn Jung Choi, Ji-Seung Yoo, Kyle Jung, Logan Rice, Dokyun Kim, Violetta Zlojutro, Matthew Frimel, Evan Madden, Un Yung Choi, Suan-Sin Foo, Younho Choi, Zhongyi Jiang, Holly Johnson, Mi-Jeong Kwak, Seokmin Kang, Brian Hong, Gil Ju Seo, Stephanie Kim, Shin-Ae Lee, Samad Amini-Bavil-Olyaee, Hadi Maazi, Omid Akbari, Kewal Asosingh, Jae U. Jung
Publikováno v:
Nature Communications, Vol 14, Iss 1, Pp 1-18 (2023)
Abstract Lung mast cells are important in host defense, and excessive proliferation or activation of these cells can cause chronic inflammatory disorders like asthma. Two parallel pathways induced by KIT–stem cell factor (SCF) and FcεRI–immunogl
Externí odkaz:
https://doaj.org/article/e12d74620b6b42939bf57f14ab7e1358
Publikováno v:
PLoS Pathogens, Vol 18, Iss 8, p e1010775 (2022)
The oral cavity is the major site for transmission of Kaposi's sarcoma-associated herpesvirus (KSHV), but how KSHV establishes infection and replication in the oral epithelia remains unclear. Here, we report a KSHV spontaneous lytic replication model
Externí odkaz:
https://doaj.org/article/d91257ececed433e9f2e2902da6b2449
Autor:
Wook-Bin Lee, Ji-Seon Kang, Won Young Choi, Quanri Zhang, Chul Han Kim, Un Yung Choi, Jeongsil Kim-Ha, Young-Joon Kim
Publikováno v:
Nature Communications, Vol 7, Iss 1, Pp 1-14 (2016)
Resolution of granulomas in mycobacterial infection requires macrophages to switch from cytokine to nitric oxide (NO) production. Here the authors show that Mincle stimulates translation of the key NO synthesis genes by a mechanism dependent on p38-m
Externí odkaz:
https://doaj.org/article/ae17c8e545c24eaeac56e1a53a11d707
Autor:
Hye-Ra Lee, Fan Li, Un Yung Choi, Hye Ryun Yu, Grace M. Aldrovandi, Pinghui Feng, Shou-Jiang Gao, Young-Kwon Hong, Jae U. Jung
Publikováno v:
mBio, Vol 9, Iss 1 (2018)
ABSTRACT Kaposi’s sarcoma-associated herpesvirus (KSHV) is the etiologic agent for Kaposi’s sarcoma (KS), which is one of the most common HIV-associated neoplasms. The endothelium is the thin layer of squamous cells where vascular blood endotheli
Externí odkaz:
https://doaj.org/article/cf50622faca94ffd8f546f12a019d261
Autor:
Un Yung Choi, Ji Yeon Hur, Myeong Sup Lee, Quanri Zhang, Won Young Choi, Lark Kyun Kim, Wook-Bin Lee, Goo Taeg Oh, Young-Joon Kim
Publikováno v:
PLoS ONE, Vol 9, Iss 4, p e95805 (2014)
To avoid excessive activation, immune signals are tightly controlled by diverse inhibitory proteins. TRIM30, a tripartite motif (TRIM)-containing protein is one of such inhibitors known to function in macrophages. To define the roles of TRIM30, we ge
Externí odkaz:
https://doaj.org/article/33927d536c2d4f16bd46950cc8fd3fc5
Autor:
Lark Kyun Kim, Un Yung Choi, Hwan Sung Cho, Jung Seon Lee, Wook-bin Lee, Jihyun Kim, Kyoungsuk Jeong, Jaewon Shim, Jeongsil Kim-Ha, Young-Joon Kim
Publikováno v:
PLoS Biology, Vol 5, Iss 9, p e238 (2007)
The activation of several transcription factors is required for the elimination of infectious pathogens via the innate immune response. The transcription factors NF-kappaB, AP-1, and STAT play major roles in the synthesis of immune effector molecules
Externí odkaz:
https://doaj.org/article/a6c87e249fb148fc9632b12232f2879d
Autor:
Suan-Sin Foo, Weiqiang Chen, Kyle L. Jung, Tamiris Azamor, Un Yung Choi, Pengfei Zhang, Suzy AA Comhair, Serpil C. Erzurum, Lara Jehi, Jae U. Jung
Publikováno v:
bioRxiv
Almost 20% of patients with COVID-19 experience long-term effects, known as post-COVID condition or long COVID. Among many lingering neurologic symptoms, chronic headache is the most common. Despite this health concern, the etiology of long COVID hea
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::50c701cb3646269009af151d81fb81af
https://europepmc.org/articles/PMC10028820/
https://europepmc.org/articles/PMC10028820/
Autor:
Un Yung Choi, Jae Jin Lee, Angela Park, Kyle L. Jung, Shin-Ae Lee, Youn Jung Choi, Hye-Ra Lee, Chih-Jen Lai, Hyungjin Eoh, Jae U. Jung
Publikováno v:
Cell Rep
Spermidine is essential for cellular growth and acts as a prerequisite of hypusination, a post-translational modification of eukaryotic initiation factor 5A (eIF5A), allowing the translation of polyproline-containing proteins. Here, we show that onco
Autor:
Angela, Park, Soohwan, Oh, Kyle L, Jung, Un Yung, Choi, Hye-Ra, Lee, Michael G, Rosenfeld, Jae U, Jung
Publikováno v:
Proc Natl Acad Sci U S A
Enhancers play indispensable roles in cell proliferation and survival through spatiotemporally regulating gene transcription. Active enhancers and superenhancers often produce noncoding enhancer RNAs (eRNAs) that precisely control RNA polymerase II a
Autor:
Shou-Jiang Gao, Un Yung Choi, Youn Jung Choi, Angela Park, Pinghui Feng, Jae Jin Lee, Claire Yu, Hye-Ra Lee, Jae U. Jung, Wei Zhu, Ji-Seung Yoo, Hyungjin Eoh, Shaochen Chen
Publikováno v:
Proc Natl Acad Sci U S A
Three-dimensional (3D) cell culture is well documented to regain intrinsic metabolic properties and to better mimic the in vivo situation than two-dimensional (2D) cell culture. Particularly, proline metabolism is critical for tumorigenesis since pyr