Zobrazeno 1 - 10
of 10
pro vyhledávání: '"Umut Ulge"'
Autor:
Evan Hall, Carlo Bifulco, Aung Naing, Anthony Joshua, Georgina Long, Margaret Callahan, Brian Costello, Aaron Hansen, Brooke Shankles, Umut Ulge, Andrew Weickhardt
Publikováno v:
Journal for ImmunoTherapy of Cancer, Vol 9, Iss Suppl 2 (2021)
Externí odkaz:
https://doaj.org/article/38e40fada5b44f479af1ab007ac9ac25
Publikováno v:
Current Opinion in Chemical Biology. 56:119-128
Engineered proteins are revolutionizing immunotherapy, but advances are still needed to harness their full potential. Traditional protein engineering methods use naturally existing proteins as a starting point, and therefore, are intrinsically limite
Autor:
Lestat R. Ali, Javier Castellanos, K. Christopher Garcia, Stephanie J. Crowley, Tamara Biary, Gonçalo J. L. Bernardes, Daniel-Adriano Silva, Mikel Ruterbusch, David Baker, Isabel Leung, Carl Walkey, Brian D. Weitzner, Shawn Yu, Marion Pepper, Alfredo Quijano-Rubio, Enrique Marcos, Fátima Pardo-Avila, Umut Ulge, Lance Stewart, Kevin Jude, Stanley R. Riddell, Michael Dougan, Jamie B. Spangler, Lauren Carter, Carlos Labão-Almeida
Publikováno v:
Nature
© 2019 Springer Nature limited. All rights reserved.
We describe a de novo computational approach for designing proteins that recapitulate the binding sites of natural cytokines, but are otherwise unrelated in topology or amino acid sequence. W
We describe a de novo computational approach for designing proteins that recapitulate the binding sites of natural cytokines, but are otherwise unrelated in topology or amino acid sequence. W
Publikováno v:
Regular and young investigator award abstracts.
Background NL-201 is a de novo IL-2 and IL-15 receptor agonist designed with enhanced affinity for IL-2Rβγ and no binding interface for IL-2Rα (CD25). Previously, we reported that NL-201 stimulates selective proliferation of CD8+ effector T cells
Autor:
Aung Naing, Margaret Callahan, Brian Costello, Brendan Curti, Evan Hall, Aaron Hansen, Georgina Long, Anthony Joshua, Brooke Shankles, Umut Ulge, Andrew Weickhardt
Publikováno v:
Journal for ImmunoTherapy of Cancer, Vol 9, Iss Suppl 2 (2021)
BackgroundNL-201 is a selective and long-acting computationally designed alpha-independent agonist of the IL-2 and IL-15 receptors, which share beta and gamma signaling subunits. NL-201 is being developed as a potent activator of CD8+ T cells and NK
Publikováno v:
Nucleic Acids Research
Homing endonucleases (HEs) promote the evolutionary persistence of selfish DNA elements by catalyzing element lateral transfer into new host organisms. The high site specificity of this lateral transfer reaction, termed homing, reflects both the leng
Publikováno v:
Nucleic Acids Research
Homing endonucleases (HEs) cleave long (∼ 20 bp) DNA target sites with high site specificity to catalyze the lateral transfer of parasitic DNA elements. In order to determine whether comprehensive computational design could be used as a general str
Generation of single-chain LAGLIDADG homing endonucleases from native homodimeric precursor proteins
Publikováno v:
Nucleic Acids Research
Homing endonucleases (HEs) cut long DNA target sites with high specificity to initiate and target the lateral transfer of mobile introns or inteins. This high site specificity of HEs makes them attractive reagents for gene targeting to promote DNA mo
Publikováno v:
Nucleic Acids Research
We used a yeast one-hybrid assay to isolate and characterize variants of the eukaryotic homing endonuclease I-PpoI that were able to bind a mutant, cleavage-resistant I-PpoI target or ‘homing’ site DNA in vivo. Native I-PpoI recognizes and cleave
Autor:
Miriam Menichelli, Summer B. Thyme, Hui Li, David Baker, Raymond J. Monnat, Umut Ulge, Austin Burt, Andrea Crisanti, Blake T. Hovde, Philippos Aris Papathanos, Nikolai Windbichler
Publikováno v:
Nature
Genetic approaches to manipulating or eradicating disease vectors have been proposed as alternatives to malaria eradication. The success of this approach depends on efficient spread of a genetic modification in field populations. Windbichler et al. s