Zobrazeno 1 - 10
of 13
pro vyhledávání: '"Umut, Karakus"'
Autor:
Alba Escalera, Manon Laporte, Sam Turner, Umut Karakus, Ana S. Gonzalez-Reiche, Adriana van de Guchte, Keith Farrugia, Zain Khalil, Harm van Bakel, Derek Smith, Adolfo García-Sastre, Teresa Aydillo
Publikováno v:
Emerging Microbes and Infections, Vol 13, Iss 1 (2024)
ABSTRACTSARS-CoV-2 Omicron subvariants are still emerging and spreading worldwide. These variants contain a high number of polymorphisms in the spike (S) glycoprotein that could potentially impact their pathogenicity and transmission. We have previou
Externí odkaz:
https://doaj.org/article/dd636ff1dfcb4a6788fca9dc5eec9110
Autor:
Nikolas Friedrich, Emanuel Stiegeler, Matthias Glögl, Thomas Lemmin, Simon Hansen, Claus Kadelka, Yufan Wu, Patrick Ernst, Liridona Maliqi, Caio Foulkes, Mylène Morin, Mustafa Eroglu, Thomas Liechti, Branislav Ivan, Thomas Reinberg, Jonas V. Schaefer, Umut Karakus, Stephan Ursprung, Axel Mann, Peter Rusert, Roger D. Kouyos, John A. Robinson, Huldrych F. Günthard, Andreas Plückthun, Alexandra Trkola
Publikováno v:
Nature Communications, Vol 12, Iss 1, Pp 1-18 (2021)
The V3-crown of the HIV-1 envelope protein largely elicits non-neutralizing antibodies. Here, the authors show that the V3-crown can be targeted by broadly neutralizing designed ankyrin repeat proteins recognizing two conformations one of which resem
Externí odkaz:
https://doaj.org/article/ecac0450d3ce4cd7a9cab854f96059f2
Autor:
Sonja Fernbach, Eva E. Spieler, Idoia Busnadiego, Umut Karakus, Anouk Lkharrazi, Silke Stertz, Benjamin G. Hale
Publikováno v:
Cell Reports, Vol 38, Iss 12, Pp 110549- (2022)
Summary: Host interferons (IFNs) powerfully restrict viruses through the action of several hundred IFN-stimulated gene (ISG) products, many of which remain uncharacterized. Here, using RNAi screening, we identify several ISG restriction factors with
Externí odkaz:
https://doaj.org/article/c7fe089cf64945cbabb2229136207bb2
Autor:
Marie O Pohl, Idoia Busnadiego, Verena Kufner, Irina Glas, Umut Karakus, Stefan Schmutz, Maryam Zaheri, Irene Abela, Alexandra Trkola, Michael Huber, Silke Stertz, Benjamin G Hale
Publikováno v:
PLoS Biology, Vol 19, Iss 3, p e3001006 (2021)
Since entering the human population, Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2; the causative agent of Coronavirus Disease 2019 [COVID-19]) has spread worldwide, causing >100 million infections and >2 million deaths. While large-sca
Externí odkaz:
https://doaj.org/article/942eb63eba2e43ccbc2ad9759b98db2c
Autor:
Idoia Busnadiego, Sonja Fernbach, Marie O. Pohl, Umut Karakus, Michael Huber, Alexandra Trkola, Silke Stertz, Benjamin G. Hale
Publikováno v:
mBio, Vol 11, Iss 5 (2020)
ABSTRACT Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), the cause of coronavirus disease 2019 (COVID-19), is a recently emerged respiratory coronavirus that has infected >23 million people worldwide with >800,000 deaths. Few COVID-19 t
Externí odkaz:
https://doaj.org/article/fa5798cc3bce4c0196b825fcd06ded1e
Autor:
Emilio Yángüez, Annika Hunziker, Maria Pamela Dobay, Soner Yildiz, Simon Schading, Elizaveta Elshina, Umut Karakus, Peter Gehrig, Jonas Grossmann, Ronald Dijkman, Mirco Schmolke, Silke Stertz
Publikováno v:
Nature Communications, Vol 9, Iss 1, Pp 1-13 (2018)
Influenza A virus (IAV) causes annual epidemics and development of antivirals is needed. Here, the authors perform phosphoproteomics during IAV entry and identify GRK2 as drug target, inhibition of which decreases replication of seasonal and pandemic
Externí odkaz:
https://doaj.org/article/75fc5e0fffec45b99c4b42c17dc10447
Autor:
Caio Foulkes, Roger D. Kouyos, Jonas V. Schaefer, Mustafa Eroglu, Stephan Ursprung, Mylène Morin, Andreas Plückthun, Thomas Liechti, Thomas Lemmin, Peter Rusert, Matthias Glögl, Yufan Wu, Thomas Reinberg, Simon Hansen, Axel Mann, Emanuel Stiegeler, Umut Karakus, Huldrych F. Günthard, Nikolas Friedrich, Branislav Ivan, L. Maliqi, Patrick Ernst, Claus Kadelka, John A. Robinson, Alexandra Trkola
Publikováno v:
Nature Communications
Nature Communications, Vol 12, Iss 1, Pp 1-18 (2021)
nature communications
Nature Communications, 12 (1)
Nature Communications, Vol 12, Iss 1, Pp 1-18 (2021)
nature communications
Nature Communications, 12 (1)
The V3 loop of the HIV-1 envelope (Env) protein elicits a vigorous, but largely non-neutralizing antibody response directed to the V3-crown, whereas rare broadly neutralizing antibodies (bnAbs) target the V3-base. Challenging this view, we present V3
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::dee2957c6d1a0b3b371dbdbdb4210fc6
https://www.repository.cam.ac.uk/handle/1810/332402
https://www.repository.cam.ac.uk/handle/1810/332402
Autor:
Sonja, Fernbach, Eva E, Spieler, Idoia, Busnadiego, Umut, Karakus, Anouk, Lkharrazi, Silke, Stertz, Benjamin G, Hale
Publikováno v:
Cell reports. 38(12)
Host interferons (IFNs) powerfully restrict viruses through the action of several hundred IFN-stimulated gene (ISG) products, many of which remain uncharacterized. Here, using RNAi screening, we identify several ISG restriction factors with previousl
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::29ae12d6d80e17a111e4f14a2c128f48
https://pubmed.ncbi.nlm.nih.gov/35320721
https://pubmed.ncbi.nlm.nih.gov/35320721
Autor:
Eva E. Spieler, Benjamin G. Hale, Milagros Sempere Borau, Adolfo García-Sastre, Carsten Magnus, Silke Stertz, Michael Schotsaert, Eva Moritz, Annika Hunziker, Alexandra Trkola, Sira C. Günther, Caroline Lanz, Carles Martínez-Romero, Umut Karakus
Publikováno v:
The Journal of Experimental Medicine
Journal of Experimental Medicine, 218 (6)
Journal of Experimental Medicine, 218 (6)
Lanz et al. reveal that IFITM3, an effector protein of the IFN response, can compete with influenza virus glycoproteins for incorporation into viral particles. This decrease in viral glycoprotein content sensitizes influenza virus to antibody-mediate
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8dd45841d8877b07783e243e0cfa9867
http://europepmc.org/articles/PMC8072448
http://europepmc.org/articles/PMC8072448
Publikováno v:
J Virol
The influenza A virus (IAV) envelope protein hemagglutinin binds α2,6- or α2,3-linked sialic acid as a host cell receptor. Bat IAV subtypes H17N10 and H18N11 form an exception to this rule and do not bind sialic acid but enter cells via major histo
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::10bef747b22fb7bcbf92523589b1b07c
https://doi.org/10.1128/jvi.01357-19
https://doi.org/10.1128/jvi.01357-19