Process development for an effective COVID-19 vaccine candidate harboring recombinant SARS-CoV-2 delta plus receptor binding domain produced by Pichia pastoris

Autor: Sibel Kalyoncu, Semiramis Yilmaz, Ayca Zeybek Kuyucu, Dogu Sayili, Olcay Mert, Hakan Soyturk, Seyda Gullu, Huseyin Akinturk, Erhan Citak, Merve Arslan, Melda Guray Taskinarda, Ibrahim Oguzhan Tarman, Gizem Yilmazer Altun, Ceren Ozer, Ridvan Orkut, Aysegul Demirtas, Idil Tilmensagir, Umur Keles, Ceren Ulker, Gizem Aralan, Yavuz Mercan, Muge Ozkan, Hasan Onur Caglar, Gizem Arik, Mehmet Can Ucar, Muzaffer Yildirim, Tugce Canavar Yildirim, Dilara Karadag, Erhan Bal, Aybike Erdogan, Serif Senturk, Serdar Uzar, Hakan Enul, Cumhur Adiay, Fahriye Sarac, Arzu Tas Ekiz, Irem Abaci, Ozge Aksoy, Hivda Ulbegi Polat, Saban Tekin, Stefan Dimitrov, Aykut Ozkul, Gerhard Wingender, Ihsan Gursel, Mehmet Ozturk, Mehmet Inan

Publikováno v: Scientific Reports, Vol 13, Iss 1, Pp 1-14 (2023)

Abstract Recombinant protein-based SARS-CoV-2 vaccines are needed to fill the vaccine equity gap. Because protein-subunit based vaccines are easier and cheaper to produce and do not require special storage/transportation conditions, they are suitable

Externí odkaz: https://doaj.org/article/399478b705064ba69bab82d757c2112a

AXL Knock-Out in SNU475 Hepatocellular Carcinoma Cells Provides Evidence for Lethal Effect Associated with G2 Arrest and Polyploidization

Autor: Tugce Batur, Ayse Argundogan, Umur Keles, Zeynep Mutlu, Hani Alotaibi, Serif Senturk, Mehmet Ozturk

Publikováno v: International Journal of Molecular Sciences, Vol 22, Iss 13247, p 13247 (2021)
International Journal of Molecular Sciences; Volume 22; Issue 24; Pages: 13247
International Journal of Molecular Sciences

AXL, a member of the TAM family, is a promising therapeutic target due to its elevated expression in advanced hepatocellular carcinoma (HCC), particularly in association with acquired drug resistance. Previously, RNA interference was used to study it

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::af6b5ad7803e8afa23508fc592eadb7d
https://www.mdpi.com/1422-0067/22/24/13247

Differential expression of full-length and NH(2) terminally truncated FAM134B isoforms in normal physiology and cancer

Autor: Muhittin Serdar, Gökhan Karakülah, Erhan Bal, Umur Keles, Sila Kahyaoglu, Neşe Atabey, Evin Iscan, Mehmet Ozturk, Ayse Derya Cavga, Nilgun Tasdemir, Zeynep Mutlu, Umut Ekin, Aslı Suner, Huriye Erbak Yilmaz

Publikováno v: Am J Physiol Gastrointest Liver Physiol
American journal of physiology. Gastrointestinal and liver physiology

Keles U, Iscan E, Yilmaz HE, Karakulah G, Suner A, Bal E, Tasdemir N, Cavga AD, Ekin U, Mutlu Z, Kahyaoglu S, Serdar MA, Atabey N, Ozturk M. Differential expression of full-length and NH2terminally truncated FAM134B isoforms in normal physiology and

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::932fadd0934a29b756ede753d57283e9
https://europepmc.org/articles/PMC7864244/

Genetics and epigenetics of liver cancer

Autor: Dilek Cevik, Mehmet Ozturk, Cigdem Ozen, Umur Keles, Alper Tunga Dagcan, Hande Topel, Gokhan Yildiz, Aysegul Ors

Publikováno v: New Biotechnology

Conference Name: 15th European Congress on Biotechnology, (ECB15) 2012 Date of Conference: 23-26 September 2012 Hepatocellular carcinoma (HCC) represents a major form of primary liver cancer in adults. Chronic infections with hepatitis B (HBV) and C

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::62a27912cb320c3f63e0d4c8d5a252bb
https://pubmed.ncbi.nlm.nih.gov/23392071