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Structure of the Mycobacterium tuberculosis type VII secretion system chaperone EspG(5) in complex with PE25-PPE41 dimer

Autor: Korotkova, N., Freire, D., Phan, T.H., Ummels, R., Creekmore, C.C., Evans, T.J., Wilmanns, M., Bitter, W., Parret, A.H.A., Houben, E.N.G., Korotkov, K.V.

Publikováno v: Molecular Microbiology, 94(2), 367-382. Wiley-Blackwell
Korotkova, N, Freire, D, Phan, T H, Ummels, R, Creekmore, C C, Evans, T J, Wilmanns, M, Bitter, W, Parret, A H A, Houben, E N G & Korotkov, K V 2014, ' Structure of the Mycobacterium tuberculosis type VII secretion system chaperone EspG(5) in complex with PE25-PPE41 dimer ', Molecular Microbiology, vol. 94, no. 2, pp. 367-382 . https://doi.org/10.1111/mmi.12770

The growth or virulence of Mycobacterium tuberculosis bacilli depends on homologous type VII secretion systems, ESX-1, ESX-3 and ESX-5, which export a number of protein effectors across membranes to the bacterial surface and environment. PE and PPE p

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=dedup_wf_001::756fdc51ec9247d4bba46d6b26825f40
https://research.vu.nl/en/publications/4397d4d5-f017-4cb1-9e97-8fcf977b3526

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Analysis of SecA2-dependent substrates in Mycobacterium marinum identifies protein kinase G (PknG) as a virulence effector

Autor: van der Woude, A.D., Stoop, E.J.M., Stiess, M., Wang, Q., Ummels, R., van Stempvoort, G., Piersma, S.R., Cascioferro, A., Jimenez, C.R., Houben, E.N.G., Luirink, J., Pieters, J., van der Sar, A.M., Bitter, W.

Publikováno v: van der Woude, A D, Stoop, E J M, Stiess, M, Wang, Q, Ummels, R, van Stempvoort, G, Piersma, S R, Cascioferro, A, Jimenez, C R, Houben, E N G, Luirink, J, Pieters, J, van der Sar, A M & Bitter, W 2014, ' Analysis of SecA2-dependent substrates in Mycobacterium marinum identifies protein kinase G (PknG) as a virulence effector. ', Cellular Microbiology, vol. 16, no. 2, pp. 280-295 . https://doi.org/10.1111/cmi.12221
Cellular Microbiology, 16(2), 280-295. Wiley-Blackwell

Summary: The pathogenicity of mycobacteria is closely associated with their ability to export virulence factors. For this purpose, mycobacteria possess different protein secretion systems, including the accessory Sec translocation pathway, SecA2. Alt

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=dedup_wf_001::d8c97797b0a5165b63bc1f3fa4e96109
https://hdl.handle.net/1871.1/4079c80a-0009-4816-a09b-57e8bb3ae29d

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Lipoarabinomannan mannose caps do not affect mycobacterial virulence or the induction of protective immunity in experimental animal models of infection and have minimal impact on in vitro inflammatory responses

Autor: afonso-barroso, a, clark, so, williams, a, rosa, gt, nobrega, c, silva-gomes, s, vale-costa, s, ummels, r, stoker, n, movahedzadeh, f, van der ley, p, sloots, a, cot, m, appelmelk, bj, puzo, g, nigou, j, geurtsen, j, appelberg, r

Publikováno v: Repositório Científico de Acesso Aberto de Portugal
Repositório Científico de Acesso Aberto de Portugal (RCAAP)
instacron:RCAAP
Cellular Microbiology; Vol 15
Cellular Microbiology, 15(4), 660-674. Wiley-Blackwell
Cellular Microbiology
Afonso-Barroso, A, Clark, S O, Williams, A, Rosa, G T, Nobrega, C, Silva-Gomes, S, Vale-Costa, S, Ummels, R, Stoker, N, Movahedzadeh, F, van der Ley, P, Sloots, A, Cot, M, Appelmelk, B J, Puzo, G, Nigou, J, Geurtsen, J J G & Appelberg, R 2013, ' Lipoarabinomannan mannose caps do not affect mycobacterial virulence or the induction of protective immunity in experimental animal models of infection and have minimal impact on in vitro inflammatory responses ', Cellular Microbiology, vol. 15, no. 4, pp. 660-674 . https://doi.org/10.1111/cmi.12065

Mannose-capped lipoarabinomannan (ManLAM) is considered an important virulence factor of Mycobacterium tuberculosis. However, while mannose caps have been reported to be responsible for various immunosuppressive activities of ManLAMobserved in vitro,

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=dedup_wf_001::f30e03f5c8590ff263502121f1d3ffe4

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Composition of the type VII secretion system membrane complex

Autor: Houben, E.N.G., Bestebroer, J., Ummels, R., Wilson, L., Piersma, S.R., Jimenez, C.R., Ottenhoff, T.H.M., Luirink, J., Bitter, W.

Publikováno v: Houben, E N G, Bestebroer, J, Ummels, R, Wilson, L, Piersma, S R, Jimenez, C R, Ottenhoff, T H M, Luirink, S & Bitter, W 2012, ' Composition of the type VII secretion system membrane complex. ', Molecular Microbiology, vol. 86, no. 2, pp. 472-484 . https://doi.org/10.1111/j.1365-2958.2012.08206.x
Molecular Microbiology, 86(2), 472-484. Wiley-Blackwell
Molecular Microbiology, 86(2), 472-484

Pathogenic mycobacteria require type VII secretion (T7S) systems to transport virulence factors across their complex cell envelope. These bacteria have up to five of these systems, termed ESX-1 to ESX-5. Here, we show that ESX-5 of Mycobacterium tube

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=dedup_wf_001::4cffa48bd6d80297af567e026f000d91
https://research.vu.nl/en/publications/576aebb0-8c8a-49a2-a85c-42eb3eba41f4

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