Repurposed dihydroorotate dehydrogenase inhibitors with efficacy against drug-resistant Acinetobacter baumannii .

Autor: Russo TA; Department of Medicine, Veterans Administration Western New York Healthcare System, Buffalo, NY 14215.; The Department of Medicine, University at Buffalo-State University of New York, Buffalo, NY 14203.; Department of Microbiology and Immunology, University at Buffalo-State University of New York, Buffalo, NY 14203.; The Witebsky Center for Microbial Pathogenesis, University at Buffalo-State University of New York, Buffalo, NY 14203., Umland TC; Department of Structural Biology, University at Buffalo State University of New York, Buffalo, NY 14203.; Hauptman Woodward Medical Research Institute, Buffalo, NY 14203., Deng X; Department of Biochemistry, University of Texas Southwestern Medical Center at Dallas, Dallas, TX 75390., El Mazouni F; Department of Biochemistry, University of Texas Southwestern Medical Center at Dallas, Dallas, TX 75390., Kokkonda S; Department of Chemistry, University of Washington, Seattle, WA 98195.; Department of Global Health, University of Washington, Seattle, WA 98195., Olson R; Department of Medicine, Veterans Administration Western New York Healthcare System, Buffalo, NY 14215.; The Department of Medicine, University at Buffalo-State University of New York, Buffalo, NY 14203., Carlino-MacDonald U; Department of Medicine, Veterans Administration Western New York Healthcare System, Buffalo, NY 14215.; The Department of Medicine, University at Buffalo-State University of New York, Buffalo, NY 14203., Beanan J; Department of Medicine, Veterans Administration Western New York Healthcare System, Buffalo, NY 14215.; The Department of Medicine, University at Buffalo-State University of New York, Buffalo, NY 14203., Alvarado CL; Department of Medicine, Veterans Administration Western New York Healthcare System, Buffalo, NY 14215.; The Department of Medicine, University at Buffalo-State University of New York, Buffalo, NY 14203., Tomchick DR; Department of Biophysics, University of Texas Southwestern Medical Center at Dallas, Dallas, TX 75390., Hutson A; Department of Biostatistics and Bioinformatics, Roswell Park Comprehensive Cancer Center, Buffalo, NY 14203., Chen H; Department of Biochemistry, University of Texas Southwestern Medical Center at Dallas, Dallas, TX 75390., Posner B; Department of Biochemistry, University of Texas Southwestern Medical Center at Dallas, Dallas, TX 75390., Rathod PK; Department of Chemistry, University of Washington, Seattle, WA 98195.; Department of Global Health, University of Washington, Seattle, WA 98195., Charman SA; Centre for Drug Candidate Optimisation, Monash Institute of Pharmaceutical Sciences, Monash University, Parkville, VIC 3052 Australia., Phillips MA; Department of Biochemistry, University of Texas Southwestern Medical Center at Dallas, Dallas, TX 75390.

Publikováno v: Proceedings of the National Academy of Sciences of the United States of America [Proc Natl Acad Sci U S A] 2022 Dec 20; Vol. 119 (51), pp. e2213116119. Date of Electronic Publication: 2022 Dec 13.

New antibacterial candidates against Acinetobacter baumannii discovered by in silico-driven chemogenomics repurposing.

Autor: Borges, Kellen Christina Malheiros^1,2 (AUTHOR), Costa, Vinícius Alexandre Fiaia³ (AUTHOR), Neves Junior, Bruno³ (AUTHOR), Kipnis, André¹ (AUTHOR) akipnis@ufg.br, Junqueira-Kipnis, Ana Paula¹ (AUTHOR)

Publikováno v: PLoS ONE. 9/26/2024, Vol. 19 Issue 9, p1-25. 25p.

Nuclear reassembly defects after mitosis trigger apoptotic and p53-dependent safeguard mechanisms in Drosophila.

Autor: Li, Jingjing^1,2 (AUTHOR), Jordana, Laia^1,2 (AUTHOR), Mehsen, Haytham^1,2 (AUTHOR), Wang, Xinyue¹ (AUTHOR), Archambault, Vincent^1,2 (AUTHOR) vincent.archambault.1@umontreal.ca

Publikováno v: PLoS Biology. 8/26/2024, Vol. 22 Issue 8, p1-29. 29p.

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