Central control of dynamic gene circuits governs T cell rest and activation

Autor: Arce, Maya M., Umhoefer, Jennifer M., Arang, Nadia, Kasinathan, Sivakanthan, Freimer, Jacob W., Steinhart, Zachary, Shen, Haolin, Pham, Minh T. N., Ota, Mineto, Wadhera, Anika, Dajani, Rama, Dorovskyi, Dmytro, Chen, Yan Yi, Liu, Qi, Zhou, Yuan, Swaney, Danielle L., Obernier, Kirsten, Shy, Brian R., Carnevale, Julia, Satpathy, Ansuman T., Krogan, Nevan J., Pritchard, Jonathan K., Marson, Alexander

Publikováno v: Nature; 20240101, Issue: Preprints p1-10, 10p

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Systematic decoding of cis gene regulation defines context-dependent control of the multi-gene costimulatory receptor locus in human T cells.

Autor: Mowery CT; Medical Scientist Training Program, University of California, San Francisco, San Francisco, CA, USA.; Biomedical Sciences Graduate Program, University of California, San Francisco, San Francisco, CA, USA.; Gladstone-UCSF Institute of Genomic Immunology, San Francisco, CA, USA.; Department of Medicine, University of California, San Francisco, San Francisco, CA, USA.; Department of Microbiology and Immunology, University of California, San Francisco, San Francisco, CA, USA., Freimer JW; Gladstone-UCSF Institute of Genomic Immunology, San Francisco, CA, USA.; Department of Medicine, University of California, San Francisco, San Francisco, CA, USA.; Department of Microbiology and Immunology, University of California, San Francisco, San Francisco, CA, USA.; Department of Genetics, Stanford University, Stanford, CA, USA., Chen Z; Department of Cancer Biology, Dana-Farber Cancer Institute, Boston, MA, USA.; Broad Institute of MIT and Harvard, Cambridge, MA, USA.; Departments of Cell Biology and Pathology, Harvard Medical School, Boston, MA, USA., Casaní-Galdón S; Department of Cancer Biology, Dana-Farber Cancer Institute, Boston, MA, USA.; Broad Institute of MIT and Harvard, Cambridge, MA, USA.; Departments of Cell Biology and Pathology, Harvard Medical School, Boston, MA, USA., Umhoefer JM; Biomedical Sciences Graduate Program, University of California, San Francisco, San Francisco, CA, USA.; Gladstone-UCSF Institute of Genomic Immunology, San Francisco, CA, USA.; Department of Medicine, University of California, San Francisco, San Francisco, CA, USA.; Department of Microbiology and Immunology, University of California, San Francisco, San Francisco, CA, USA., Arce MM; Biomedical Sciences Graduate Program, University of California, San Francisco, San Francisco, CA, USA.; Gladstone-UCSF Institute of Genomic Immunology, San Francisco, CA, USA.; Department of Medicine, University of California, San Francisco, San Francisco, CA, USA., Gjoni K; Gladstone Institute of Data Science and Biotechnology, San Francisco, CA, USA.; Department of Epidemiology and Biostatistics, University of California, San Francisco, San Francisco, CA, USA., Daniel B; Gladstone-UCSF Institute of Genomic Immunology, San Francisco, CA, USA.; Department of Pathology, Stanford University, Stanford, CA, USA.; Center for Personal Dynamic Regulomes, Stanford University, Stanford, CA, USA.; Department of Microchemistry, Proteomics, Lipidomics and Next Generation Sequencing, Genentech, South San Francisco, CA, USA., Sandor K; Gladstone-UCSF Institute of Genomic Immunology, San Francisco, CA, USA.; Department of Pathology, Stanford University, Stanford, CA, USA., Gowen BG; Innovative Genomics Institute, University of California, Berkeley, Berkeley, CA, USA.; Department of Molecular and Cell Biology, University of California, Berkeley, Berkeley, CA, USA., Nguyen V; Gladstone-UCSF Institute of Genomic Immunology, San Francisco, CA, USA.; Department of Medicine, University of California, San Francisco, San Francisco, CA, USA.; Department of Microbiology and Immunology, University of California, San Francisco, San Francisco, CA, USA.; Diabetes Center, University of California, San Francisco, San Francisco, CA, USA.; Department of Surgery, University of California, San Francisco, San Francisco, CA, USA.; UCSF CoLabs, University of California, San Francisco, San Francisco, CA, USA., Simeonov DR; Biomedical Sciences Graduate Program, University of California, San Francisco, San Francisco, CA, USA.; Department of Medicine, University of California, San Francisco, San Francisco, CA, USA.; Department of Microbiology and Immunology, University of California, San Francisco, San Francisco, CA, USA., Garrido CM; Gladstone-UCSF Institute of Genomic Immunology, San Francisco, CA, USA.; Department of Medicine, University of California, San Francisco, San Francisco, CA, USA.; Department of Microbiology and Immunology, University of California, San Francisco, San Francisco, CA, USA., Curie GL; Innovative Genomics Institute, University of California, Berkeley, Berkeley, CA, USA.; Department of Molecular and Cell Biology, University of California, Berkeley, Berkeley, CA, USA., Schmidt R; Gladstone-UCSF Institute of Genomic Immunology, San Francisco, CA, USA.; Department of Medicine, University of California, San Francisco, San Francisco, CA, USA.; Department of Microbiology and Immunology, University of California, San Francisco, San Francisco, CA, USA.; Department of Laboratory Medicine, Medical University of Vienna, Vienna, Austria., Steinhart Z; Gladstone-UCSF Institute of Genomic Immunology, San Francisco, CA, USA.; Department of Medicine, University of California, San Francisco, San Francisco, CA, USA.; Department of Microbiology and Immunology, University of California, San Francisco, San Francisco, CA, USA., Satpathy AT; Gladstone-UCSF Institute of Genomic Immunology, San Francisco, CA, USA.; Department of Pathology, Stanford University, Stanford, CA, USA.; Parker Institute for Cancer Immunotherapy, San Francisco, CA, USA.; Program in Immunology, Stanford University, Stanford, CA, USA., Pollard KS; Gladstone Institute of Data Science and Biotechnology, San Francisco, CA, USA.; Department of Epidemiology and Biostatistics, University of California, San Francisco, San Francisco, CA, USA.; Chan Zuckerberg Biohub SF, San Francisco, CA, USA., Corn JE; Innovative Genomics Institute, University of California, Berkeley, Berkeley, CA, USA.; Department of Molecular and Cell Biology, University of California, Berkeley, Berkeley, CA, USA.; Department of Biology, ETH Zürich, Zürich, Switzerland., Bernstein BE; Department of Cancer Biology, Dana-Farber Cancer Institute, Boston, MA, USA.; Broad Institute of MIT and Harvard, Cambridge, MA, USA.; Departments of Cell Biology and Pathology, Harvard Medical School, Boston, MA, USA., Ye CJ; Gladstone-UCSF Institute of Genomic Immunology, San Francisco, CA, USA. jimmie.ye@ucsf.edu.; Department of Epidemiology and Biostatistics, University of California, San Francisco, San Francisco, CA, USA. jimmie.ye@ucsf.edu.; Parker Institute for Cancer Immunotherapy, San Francisco, CA, USA. jimmie.ye@ucsf.edu.; Chan Zuckerberg Biohub SF, San Francisco, CA, USA. jimmie.ye@ucsf.edu.; Rosalind Russell/Ephraim P. Engleman Rheumatology Research Center, University of California, San Francisco, San Francisco, CA, USA. jimmie.ye@ucsf.edu.; Bakar Computational Health Sciences Institute, University of California, San Francisco, San Francisco, CA, USA. jimmie.ye@ucsf.edu.; Institute for Human Genetics, University of California, San Francisco, San Francisco, CA, USA. jimmie.ye@ucsf.edu., Marson A; Gladstone-UCSF Institute of Genomic Immunology, San Francisco, CA, USA. alexander.marson@ucsf.edu.; Department of Medicine, University of California, San Francisco, San Francisco, CA, USA. alexander.marson@ucsf.edu.; Department of Microbiology and Immunology, University of California, San Francisco, San Francisco, CA, USA. alexander.marson@ucsf.edu.; Innovative Genomics Institute, University of California, Berkeley, Berkeley, CA, USA. alexander.marson@ucsf.edu.; Parker Institute for Cancer Immunotherapy, San Francisco, CA, USA. alexander.marson@ucsf.edu.; Institute for Human Genetics, University of California, San Francisco, San Francisco, CA, USA. alexander.marson@ucsf.edu.; UCSF Helen Diller Family Comprehensive Cancer Center, University of California, San Francisco, San Francisco, CA, USA. alexander.marson@ucsf.edu.

Publikováno v: Nature genetics [Nat Genet] 2024 Jun; Vol. 56 (6), pp. 1156-1167. Date of Electronic Publication: 2024 May 29.