Zobrazeno 1 - 10
of 31
pro vyhledávání: '"Umesh S. Kestur"'
Publikováno v:
Pharmaceutics, Vol 13, Iss 5, p 735 (2021)
To reduce the dosage size of amorphous solid dispersion (ASD)-based formulations, it is of interest to devise formulation strategies that allow increased drug loading (DL) without compromising dissolution performance. The aim of this study was to exp
Externí odkaz:
https://doaj.org/article/d91d122171c4458d82cf09b41b23523f
Publikováno v:
Pharmaceutical Development and Technology. 26:41-47
The objective of this study was to understand the impact of coating excipients on the chemical stability of active pan coated peliglitazar, which was prone to acid as well as base-catalyzed degradation. Four different coating formulations containing
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f03b5b412027842f26c0b473e8cfa295
https://doi.org/10.1080/10837450.2020.1832520
https://doi.org/10.1080/10837450.2020.1832520
Publikováno v:
Journal of Controlled Release. 298:68-82
Liquid-liquid phase separation (LLPS) occurs following amorphous solid dispersion (ASD) dissolution when the drug concentration exceeds the "amorphous solubility", and is emerging as an important characteristic of formulations that may enhance the or
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::175e12eea1dbbf61826ca0a0fb8bc518
https://doi.org/10.1016/j.jconrel.2019.01.039
https://doi.org/10.1016/j.jconrel.2019.01.039
Publikováno v:
Pharmaceutics, Vol 13, Iss 735, p 735 (2021)
Pharmaceutics
Volume 13
Issue 5
Pharmaceutics
Volume 13
Issue 5
To reduce the dosage size of amorphous solid dispersion (ASD)-based formulations, it is of interest to devise formulation strategies that allow increased drug loading (DL) without compromising dissolution performance. The aim of this study was to exp
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::365e1730e887371b65c73d2cd975be52
https://doi.org/10.3390/pharmaceutics13050735
https://doi.org/10.3390/pharmaceutics13050735
Publikováno v:
Pharmaceutical Research. 33:1276-1288
Excipients are essential for solubility enhancing formulations. Hence it is important to understand how additives impact key solution properties, particularly when supersaturated solutions are generated by dissolution of the solubility enhancing form
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::40c6af9e22d2e660655db16b7b675d01
https://doi.org/10.1007/s11095-016-1871-y
https://doi.org/10.1007/s11095-016-1871-y
Publikováno v:
European Journal of Pharmaceutical Sciences. 155:105514
To reduce the pill burden associated with amorphous solid dispersions (ASDs), which arises from the large quantity of polymer used in the formulation, it is of interest to understand the relationship between drug loading and release properties. The a
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::75418c9ff70dc4378bf2e429008bf0d3
https://doi.org/10.1016/j.ejps.2020.105514
https://doi.org/10.1016/j.ejps.2020.105514
Publikováno v:
Molecular Pharmaceutics. 13:223-231
Amorphous solid dispersions (ASDs) are of great interest as enabling formulations because of their ability to increase the bioavailability of poorly soluble drugs. However, the dissolution of these formulations under nonsink dissolution conditions re
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c956d46c9b930c52916e3f558aaa2b4e
https://doi.org/10.1021/acs.molpharmaceut.5b00652
https://doi.org/10.1021/acs.molpharmaceut.5b00652
Autor:
Divyakant Desai, Hang Guo, Dan Tang, Umesh S. Kestur, Shasad Sharif, Benjamin Wong, Steven H. Chan
Publikováno v:
Pharmaceutical Development and Technology. 22:715-723
During the development of a wet granulated 850 mg metformin hydrochloride tablet formulation, the tablets exhibited high friability (>3% w/w) irrespective of the source of extra-granular magnesium stearate (MgSt). High friability values indicated tha
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::acc3b010c4be3dedfa29de181e7412bc
https://doi.org/10.3109/10837450.2015.1116562
https://doi.org/10.3109/10837450.2015.1116562
Autor:
Amy Saari, Umesh S. Kestur, Balvinder S. Vig, Divyakant Desai, Yan Xu, Aditya U. Vanarase, John R. Crison, Munir A. Hussain, Neil Mathias
Publikováno v:
The AAPS Journal. 17:988-998
In vitro and in vivo experimental models are frequently used to assess a new chemical entity’s (NCE) biopharmaceutical performance risk for food effect (FE) in humans. Their ability to predict human FE hinges on replicating key features of clinical
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c1d148e34469a703b2280811413c4ed6
https://doi.org/10.1208/s12248-015-9759-z
https://doi.org/10.1208/s12248-015-9759-z
Publikováno v:
International Journal of Pharmaceutics. 476:93-98
The objective of this work was to monitor and identify the impact of coating microenvironment, as measured by PyroButtons ® data loggers, on the chemical stability of a moisture-sensitive drug molecule brivanib alaninate (BA). BA tablets were coated
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::201b7b73a5967c5122ac7f67523fd607
https://doi.org/10.1016/j.ijpharm.2014.09.030
https://doi.org/10.1016/j.ijpharm.2014.09.030