Výsledky vyhledávání - "Umesh R Desai"

Akademický článek

The alphaherpesvirus conserved pUS10 is important for natural infection and its expression is regulated by the conserved Herpesviridae protein kinase (CHPK).

Autor: Nagendraprabhu Ponnuraj, Haji Akbar, Justine V Arrington, Stephen J Spatz, Balaji Nagarajan, Umesh R Desai, Keith W Jarosinski

Publikováno v: PLoS Pathogens, Vol 19, Iss 2, p e1010959 (2023)

Conserved Herpesviridae protein kinases (CHPK) are conserved among all members of the Herpesviridae. Herpesviruses lacking CHPK propagate in cell culture at varying degrees, depending on the virus and cell culture system. CHPK is dispensable for Mare

Externí odkaz: https://doaj.org/article/d1e3750fe8ec4e24a37fe9bdfbcfd2b3

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Akademický článek

Maintaining pH-dependent conformational flexibility of M1 is critical for efficient influenza A virus replication

Autor: Meng-Jung Chiang, Faik N Musayev, Martina Kosikova, Zhengshi Lin, Yamei Gao, Philip D Mosier, Bashayer Althufairi, Zhiping Ye, Qibing Zhou, Umesh R Desai, Hang Xie, Martin K Safo

Publikováno v: Emerging Microbes and Infections, Vol 6, Iss 1, Pp 1-11 (2017)

The M gene segment of influenza A virus has been shown to be a contributing factor to the high growth phenotype. However, it remains largely unknown why matrix protein 1 (M1), the major structural protein encoded by M gene, exhibits pH-dependent conf

Externí odkaz: https://doaj.org/article/012e972efd224b868ea35d92c5d90cd6

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Akademický článek

A molecular dynamics-based algorithm for evaluating the glycosaminoglycan mimicking potential of synthetic, homogenous, sulfated small molecules.

Autor: Balaji Nagarajan, Nehru Viji Sankaranarayanan, Bhaumik B Patel, Umesh R Desai

Publikováno v: PLoS ONE, Vol 12, Iss 2, p e0171619 (2017)

Glycosaminoglycans (GAGs) are key natural biopolymers that exhibit a range of biological functions including growth and differentiation. Despite this multiplicity of function, natural GAG sequences have not yielded drugs because of problems of hetero

Externí odkaz: https://doaj.org/article/a817105fbb7b46249a7bfc0a491725be

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Akademický článek

Allosteric Inhibition of Factor XIIIa. Non-Saccharide Glycosaminoglycan Mimetics, but Not Glycosaminoglycans, Exhibit Promising Inhibition Profile.

Autor: Rami A Al-Horani, Rajesh Karuturi, Michael Lee, Daniel K Afosah, Umesh R Desai

Publikováno v: PLoS ONE, Vol 11, Iss 7, p e0160189 (2016)

Factor XIIIa (FXIIIa) is a transglutaminase that catalyzes the last step in the coagulation process. Orthostery is the only approach that has been exploited to design FXIIIa inhibitors. Yet, allosteric inhibition of FXIIIa is a paradigm that may offe

Externí odkaz: https://doaj.org/article/1fb45436284b443e823ef4bf5c1506f3

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Akademický článek

A Simple Method for Discovering Druggable, Specific Glycosaminoglycan-Protein Systems. Elucidation of Key Principles from Heparin/Heparan Sulfate-Binding Proteins.

Autor: Aurijit Sarkar, Umesh R Desai

Publikováno v: PLoS ONE, Vol 10, Iss 10, p e0141127 (2015)

Glycosaminoglycans (GAGs) affect human physiology and pathology by modulating more than 500 proteins. GAG-protein interactions are generally assumed to be ionic and nonspecific, but specific interactions do exist. Here, we present a simple method to

Externí odkaz: https://doaj.org/article/8cd388da20184816bf47b7afba1fcc77

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Akademický článek

6-Hydroxyflavone and derivatives exhibit potent anti-inflammatory activity among mono-, di- and polyhydroxylated flavones in kidney mesangial cells.

Autor: Xing Wang, Zhiwei Wang, Preetpal Singh Sidhu, Umesh R Desai, Qibing Zhou

Publikováno v: PLoS ONE, Vol 10, Iss 3, p e0116409 (2015)

Inflammatory responses by kidney mesangial cells play a critical role in the glomerulonephritis. The anti-inflammatory potential of nineteen mono-, di- and polyhydroxylated flavones including fisetin, quercetin, morin, tricetin, gossypetin, apigenin

Externí odkaz: https://doaj.org/article/58882358a42641cd8372bcaf8e6a713e

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Akademický článek

Crystal structures of influenza A virus matrix protein M1: variations on a theme.

Autor: Martin K Safo, Faik N Musayev, Philip D Mosier, Qibing Zhou, Hang Xie, Umesh R Desai

Publikováno v: PLoS ONE, Vol 9, Iss 10, p e109510 (2014)

Matrix protein 1 (M1) of the influenza A virus plays multiple roles in virion assembly and infection. Interest in the pH dependence of M1's multiple functions led us to study the effect of subtle pH changes on M1 structure, resulting in the elucidati

Externí odkaz: https://doaj.org/article/fffd62a16ceb459b9bf81f3aab59f1b6

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Akademický článek

On the specificity of heparin/heparan sulfate binding to proteins. Anion-binding sites on antithrombin and thrombin are fundamentally different.

Autor: Philip D Mosier, Chandravel Krishnasamy, Glen E Kellogg, Umesh R Desai

Publikováno v: PLoS ONE, Vol 7, Iss 11, p e48632 (2012)

The antithrombin-heparin/heparan sulfate (H/HS) and thrombin-H/HS interactions are recognized as prototypic specific and non-specific glycosaminoglycan (GAG)-protein interactions, respectively. The fundamental structural basis for the origin of speci

Externí odkaz: https://doaj.org/article/d33788b9c3f544ec9e9f9a78132156d4

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