Zobrazeno 1 - 3
of 3
pro vyhledávání: '"Umesh Parasharam Aher"'
Publikováno v:
Beilstein Journal of Organic Chemistry, Vol 17, Iss 1, Pp 2680-2715 (2021)
Beilstein Journal of Organic Chemistry
Beilstein Journal of Organic Chemistry
Sugar-modified nucleosides have gained considerable attention in the scientific community, either for use as molecular probes or as therapeutic agents. When the methylene group of the ribose ring is replaced with a sulfur atom at the 3’-position, t
Autor:
Dhananjai Srivastava, Harishchandra Sambhaji Jadhav, BS Jayashree, Gautham G. Shenoy, Umesh Parasharam Aher, Girij Pal Singh
Publikováno v:
Organic Process Research & Development. 24:387-397
A stereoselective large-scale synthetic process is described to produce 1,3-oxathiolane nucleoside, lamivudine. A mild, inexpensive, and readily available zirconium (IV) chloride (ZrCl4) catalyst a...
Autor:
Girij Pal Singh, Harishchandra Sambhaji Jadhav, Bhairab Nath Roy, Manmeet Brijkishore Saini, Umesh Parasharam Aher, Dhananjai Srivastava
Publikováno v:
Organic Process Research & Development. 13:450-455
A large-scale synthesis of (−)-[2R,5S]-4-amino-1- [2-(hydroxymethyl)-1,3-oxathiolan-5-yl]-2(1H)-pyrimidin-2-one (lamivudine) through resolution of racemic lamivudine by cocrystal formation with (S)- BINOL has been demonstrated. Lamivudine of very h