Výsledky vyhledávání - "Umesh, Todmal"

Pharmacokinetics of Darolutamide in Mouse - Assessment of the Disposition of the Diastereomers, Key Active Metabolite and Interconversion Phenomenon: Implications to Cancer Patients

Autor: Mohd Zainuddin, Umesh Todmal, Narayanan Balaji, Ramesh Mullangi, Nuggehally R. Srinivas, Bhavesh Babulal Gabani, Vinay Kiran, Saibabu Polina, Neeraj Kumar Saini, Suresh P. Sulochana

Publikováno v: Drug Metabolism Letters. 14:54-65

Background: Darolutamide is recently approved for the treatment of non-metastatic castrate resistance prostate cancer. Hitherto, no stereoselective pharmacokinetic data have been published pertaining to darolutamide and its diastereomers in animals o

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d255aa35ad9c89522fecbcdc8eb1149f
https://doi.org/10.2174/1872312814666200521091236

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Validated LC-MS/MS Method for Simultaneous Quantitation of Three PI3K Inhibitors, Copanlisib, Duvelisib and Idelalisib in Mouse Plasma: Application to a Pharmacokinetic Study in Mice

Autor: Pavan Kumar Kurakula, Umesh Todmal, Mohd Zainuddin, Sreekanth Dittakavi, Ravi Kumar Trivedi, Ramesh Mullangi, Bhavesh Babulal Gabani

Phosphatidylinositol 3-kinase (PI3K) inhibitors are emerging novel class of anticancer drugs. In this work, we report the development and validation of an LC-MS/MS method for the simultaneous quantitation of three PI3K inhibitors namely copanlisib, d

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::07d340aaf016382d2fc64a56bc163da8

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Preparation and optimization of nilotinib self-micro-emulsifying drug delivery systems to enhance oral bioavailability

Autor: Ashok Zakkula, Ravi Kumar Jairam, Bhavesh Babulal Gabani, Vinay Kiran, Ramesh Mullangi, Umesh Todmal

Publikováno v: Drug development and industrial pharmacy. 46(3)

Objective: The objective of the current research was to prepare self-micro-emulsifying drug delivery systems (SMEDDS) for BCS class II drug, nilotinib to enhance its oral bioavailability.Methodolog...

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::cccc24cc03fb9545ced942c382e9ab81
https://pubmed.ncbi.nlm.nih.gov/32067499

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RP-HPLC-UV Method for Simultaneous Quantification of Second Generation Non-Steroidal Antiandrogens Along with their Active Metabolites in Mice Plasma: Application to a Pharmacokinetic Study

Autor: Umesh Todmal, Suresh P. Sulochana, Ashok Zakkula, Ramesh Mullangi, Vinay Kiran

Publikováno v: Drug Research. 69:537-544

A simple, specific and reproducible high-performance liquid chromatography (HPLC) assay method has been developed and validated for the quantitation of second generation antiandrogens and their active metabolites namely apalutamide, enzalutamide, N-d

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5894921587a0d15dbabba4c2f74c4058
https://doi.org/10.1055/a-0790-8309

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Validation of an LC–MS/MS Method for Simultaneous Detection of Five Selective KCNQ Channel Openers: ICA-27243, ML-213, PF-05020182, SF-0034 and Flupirtine in Mice Plasma and its Application to a Pharmacokinetic Study in Mice

Autor: Umesh Todmal, Gurulingappa Hallur, Ramesh Mullangi, Sridharan Rajagopal, Suresh P. Sulochana, Ravi Kanth Bhamidipati, Swapan Kumar Samanta, Mohd Zainuddin, Sriram Rajagopal

Publikováno v: Chromatographia. 81:457-468

A sensitive and rapid LC–MS/MS method was developed and validated for the simultaneous quantitation of five selective KCNQ channel openers, namely ICA-27243, ML-213, PF-05020182, SF-0034 and flupirtine in mice plasma as per regulatory guideline. Th

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::cc1ef7004177cd1b0e45d532fbab906f
https://doi.org/10.1007/s10337-018-3472-x

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Validated LC–ESI–MS/MS method for the determination of tunicamycin in rat plasma: Application to a pharmacokinetic study

Autor: Bhavesh Babulal Gabani, Vinay Kiran, Umesh Todmal, Suresh P. Sulochana, Ramesh Mullangi

Publikováno v: Biomedical Chromatography.

A liquid chromatography coupled to tandem mass spectrometry (LC-MS/MS) method has been developed and validated for the quantification of tunicamycin in rat plasma as per regulatory guideline. Chromatography of tunicamycin and the IS in the processed

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8401f51af2e8123f964e18ebe1588e98
https://doi.org/10.1002/bmc.4661

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Stereoselective pharmacokinetics and tissue distribution of levodropropizine after administration of pure levodropropizine and the

Autor: Bhavesh Babulal, Gabani, Umesh, Todmal, Neeraj Kumar, Saini, Vinod A, Balakrishna, Suresh P, Sulochana, Ashok, Timmapuram, Mohd, Zainuddin, Narayanan, Balaji, Praharaj, Shuvranshu, Nuggehally R, Srinivas, Ramesh, Mullangi

Publikováno v: Xenobiotica; the fate of foreign compounds in biological systems. 50(2)

Levodropropizine (LDP) is a non-opioid anti-tussive. The stereoselective pharmacokinetics and tissue distribution (TD) of LDP vs. dextrodropropizine (DDP) have been characterized after oral and

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::993c4f5216365a3e940caeee3bb86bdd
https://pubmed.ncbi.nlm.nih.gov/30896275

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Enantioselective LC-ESI-MS/MS determination of dropropizine enantiomers in rat plasma and application to a pharmacokinetic study

Autor: Rajesh Chandran, Ramesh Mullangi, Umesh Todmal, Neeraj Kumar Saini, Suresh P. Sulochana, Narayanan Balaji, Bhavesh Babulal Gabani

Publikováno v: Biomedical chromatography : BMC. 33(3)

We developed and validated a simple, sensitive, selective and reliable LC-ESI-MS/MS method for direct quantitation of dropropizine enantiomers namely levodropropizine (LDP) and dextrodropropizine (DDP) in rat plasma without the need for derivatizatio

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0a8b1d7b29b72891a67286b9a3e7ac9a
https://pubmed.ncbi.nlm.nih.gov/30426526

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Validated LC-MS-MS Method for Determination of SF0034 in Mice Plasma: Application to a Pharmacokinetic Study in Mice

Autor: Umesh Todmal, P. Suresh, Ravi Kanth Bhamidipati, Swapan Kumar Samanta, Ramesh Mullangi, Sridharan Rajagopal, Gurulingappa Hallur, Mohd Zainuddin, Sriram Rajagopal

Publikováno v: Journal of chromatographic science. 55(7)

A rapid and sensitive assay method has been developed and validated using liquid chromatography coupled to tandem mass spectrometry with electrospray ionization in the positive-ion mode for the estimation of SF0034 in mice plasma. The assay procedure

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::dd4a37933de791f7ce0173c99a71b968
https://pubmed.ncbi.nlm.nih.gov/28383683

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