Zobrazeno 1 - 10
of 110
pro vyhledávání: '"Umeharu Ohto"'
Publikováno v:
Communications Biology, Vol 7, Iss 1, Pp 1-10 (2024)
Abstract Two mammalian homologs of systemic RNA interference defective protein 1 (SID-1) (SIDT1/2) are suggested to function as double-stranded RNA (dsRNA) transporters for extracellular dsRNA uptake or for release of incorporated dsRNA from lysosome
Externí odkaz:
https://doaj.org/article/63c4d99fbbad47928381bb7d7daff641
Autor:
Kentaro Sakaniwa, Akiko Fujimura, Takuma Shibata, Hideki Shigematsu, Toru Ekimoto, Masaki Yamamoto, Mitsunori Ikeguchi, Kensuke Miyake, Umeharu Ohto, Toshiyuki Shimizu
Publikováno v:
Nature Communications, Vol 14, Iss 1, Pp 1-8 (2023)
TLR3 activates a potent immune response by binding to dsRNA. Here the authors report cryo-EM analyses to show that TLR3 dimers laterally form a higher multimeric complex along dsRNA, providing the basis for cooperative binding and efficient signal tr
Externí odkaz:
https://doaj.org/article/191eb9ffbbaf4c64a5feaddd969568ae
Autor:
Zhikuan Zhang, Norimichi Nomura, Yukiko Muramoto, Toru Ekimoto, Tomoko Uemura, Kehong Liu, Moeko Yui, Nozomu Kono, Junken Aoki, Mitsunori Ikeguchi, Takeshi Noda, So Iwata, Umeharu Ohto, Toshiyuki Shimizu
Publikováno v:
Nature Communications, Vol 13, Iss 1, Pp 1-12 (2022)
M protein plays essential roles in virus assembly and morphogenesis. Here, authors reveal two cryo-EM structures of M protein from SARS-CoV-2 that suggest conformational dynamics of M protein and its role in virus assembly.
Externí odkaz:
https://doaj.org/article/a5db8836d0a44eb0879660163e86a76f
Autor:
Yi Yang, Adam Csakai, Shuangshuang Jiang, Christina Smith, Hiromi Tanji, Jian Huang, Torey Jones, Kentaro Sakaniwa, Lindsey Broadwell, Chengrui Shi, Subada Soti, Umeharu Ohto, Yaohui Fang, Shu Shen, Fei Deng, Toshiyuki Shimizu, Hang Yin
Publikováno v:
Nature Communications, Vol 12, Iss 1, Pp 1-9 (2021)
Toll-like receptor 8 (TLR8) plays essential roles in the innate immune response to viral single-stranded RNA (ssRNA), so small molecule modulators of TLR8 are of interest, however adverse effects limit their use. Here, the authors report a tetrasubst
Externí odkaz:
https://doaj.org/article/83bd70c8f89a49098e079e0d211e760d
Autor:
Umeharu Ohto
Publikováno v:
Frontiers in Immunology, Vol 13 (2022)
Innate immunity is a primary defense system against microbial infections. Innate immune pattern recognition receptors (PRRs) play pivotal roles in detection of invading pathogens. When pathogens, such as bacteria and viruses, invade our bodies, their
Externí odkaz:
https://doaj.org/article/e55c04aee1934a7abb1c2b713ba0ced6
Autor:
Shingo Tojo, Zhikuan Zhang, Hiroyuki Matsui, Masahiro Tahara, Mitsunori Ikeguchi, Mami Kochi, Mami Kamada, Hideki Shigematsu, Akihisa Tsutsumi, Naruhiko Adachi, Takuma Shibata, Masaki Yamamoto, Masahide Kikkawa, Toshiya Senda, Yoshiaki Isobe, Umeharu Ohto, Toshiyuki Shimizu
Publikováno v:
Nature Communications, Vol 11, Iss 1, Pp 1-11 (2020)
A series of Toll-like receptor 7 (TLR7)-specific antagonists and extensive structural analysis reveal the open conformation of the receptor and the structural basis of TLR7 antagonism. One of the compounds shows efficacy in treating mouse model of sy
Externí odkaz:
https://doaj.org/article/be81925ea7f144b39dd225d5ffceb7a8
Autor:
Yuqun Xu, Takuya Miyakawa, Shohei Nosaki, Akira Nakamura, Ying Lyu, Hidemitsu Nakamura, Umeharu Ohto, Hanako Ishida, Toshiyuki Shimizu, Tadao Asami, Masaru Tanokura
Publikováno v:
Nature Communications, Vol 9, Iss 1, Pp 1-11 (2018)
HTL and D14 receptors perceive the structurally similar signaling compounds karrikin and strigolactone. Here, the authors show that ShD14 and a divergent clade of ShHTLs from Strigae capable of recognizing strigolact are capable of recognizing strigo
Externí odkaz:
https://doaj.org/article/42ae383f7fea4ea29f91a971b62f2613
Autor:
Eicke Latz, Friederike Gorki, Lenka Dohnalová, Christoph Thaiss, Jelena Zurkovic, Anette Christ, Umeharu Ohto, Jan Marzinek, Peter J. Bond, Eike Geißmar, Santu Singha, Arslan Hamid, Mohamed Yaghmour, Kyra de Goede, Maximilian Rothe, Katarzyna Placek, Amin Polzin, Philipp Wollnitzke, Bodo Levkau, Michael Fitzgerald, Joost Rutten, Mihai Netea, Niels Riksen, Christoph Thiele, Andreas Pfeiffer, Peter Düwell, Jan Van den Bossche
Chronic low-grade inflammation, also called metaflammation, is associated with prevalent non-communicable diseases, such as atherosclerosis. Anti-inflammatory therapy provides a clinical benefit in patients, but the triggers that incite metaflammatio
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::87ebfd6252277ef95cea848d7a335543
https://doi.org/10.21203/rs.3.rs-2792338/v1
https://doi.org/10.21203/rs.3.rs-2792338/v1
Autor:
Jinta Asami, Kanako Terakado Kimura, Yoko Fujita-Fujiharu, Hanako Ishida, Zhikuan Zhang, Yayoi Nomura, Kehong Liu, Tomoko Uemura, Yumi Sato, Masatsugu Ono, Masaki Yamamoto, Takeshi Noda, Hideki Shigematsu, David Drew, So Iwata, Toshiyuki Shimizu, Norimichi Nomura, Umeharu Ohto
Publikováno v:
Nature. 606:1021-1026
Chronic infection with hepatitis B virus (HBV) affects more than 290 million people worldwide, is a major cause of cirrhosis and hepatocellular carcinoma, and results in an estimated 820,000 deaths annually
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e4781eb3c3355fe40aa3b2d2a8f2f072
https://doi.org/10.1038/s41586-022-04845-4
https://doi.org/10.1038/s41586-022-04845-4
Publikováno v:
Nature Communications, Vol 7, Iss 1, Pp 1-11 (2016)
NOD2 has a role in host innate immune responses, activating the NF-κB signalling pathway and mutations have been associated with chronic inflammatory disorders. Here, Maekawa et al. solved the structure of NOD2 in its inactive form, suggesting a mec
Externí odkaz:
https://doaj.org/article/7427180e5bf844dd9f3a66b77937b088