Zobrazeno 1 - 10
of 15
pro vyhledávání: '"Ume-Kulsoom Shah"'
Autor:
Samantha V. Llewellyn, Gillian E. Conway, Ilaria Zanoni, Amalie Kofoed Jørgensen, Ume-Kulsoom Shah, Didem Ag Seleci, Johannes G. Keller, Jeong Won Kim, Wendel Wohlleben, Keld Alstrup Jensen, Anna Costa, Gareth J. S. Jenkins, Martin J. D. Clift, Shareen H. Doak
Publikováno v:
Journal of Nanobiotechnology, Vol 19, Iss 1, Pp 1-24 (2021)
Abstract Background With the continued integration of engineered nanomaterials (ENMs) into everyday applications, it is important to understand their potential for inducing adverse human health effects. However, standard in vitro hazard characterisat
Externí odkaz:
https://doaj.org/article/a7986442632e40378669f55646113773
Autor:
Anna Luisa Costa, Johannes Keller, Wendel Wohlleben, Gareth J.S. Jenkins, Ume-Kulsoom Shah, Jeong Won Kim, Keld Alstrup Jensen, Samantha V. Llewellyn, Martin J. D. Clift, Didem Ag Seleci, Shareen H. Doak, Gillian E. Conway, Amalie Kofoed Jørgensen, Ilaria Zanoni
Publikováno v:
Journal of Nanobiotechnology, Vol 19, Iss 1, Pp 1-24 (2021)
Journal of Nanobiotechnology
Journal of Nanobiotechnology
Background With the continued integration of engineered nanomaterials (ENMs) into everyday applications, it is important to understand their potential for inducing adverse human health effects. However, standard in vitro hazard characterisation appro
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::20b53c9862987c5b53aa9fd3c93d886c
https://doaj.org/article/a7986442632e40378669f55646113773
https://doaj.org/article/a7986442632e40378669f55646113773
Autor:
Martin J. D. Clift, Gillian E. Conway, Tereza Cervena, Gareth J.S. Jenkins, Ume-Kulsoom Shah, Abdullah S Al Ali, Shareen H. Doak, Samantha V. Llewellyn, Stephen J. Evans
Publikováno v:
Mutagenesis
Following advancements in the field of genotoxicology, it has become widely accepted that 3D models are not only more physiologically relevant but also have the capacity to elucidate more complex biological processes that standard 2D monocultures are
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4511305c9ae8085d0d46faa3aead79a3
https://doi.org/10.1093/mutage/geab013
https://doi.org/10.1093/mutage/geab013
Autor:
Gareth J.S. Jenkins, Shareen H. Doak, Demi Pritchard, Emrah Dural, Ume-Kulsoom Shah, Katherine E. Chapman
Publikováno v:
Mutagenesis. 35:479-489
In this study, we have studied the cytotoxicity and genotoxic potency of 3 pro-oxidants; H2O2, menadione and KBrO3 in different dosing scenarios, namely acute (1-day dosing) and chronic (5-days). For this purpose, relative population doubling (RPD%)
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1f9d58cbf02fb5caaf3c8cc3a8288246
https://doi.org/10.1093/mutage/geaa024
https://doi.org/10.1093/mutage/geaa024
Autor:
James A. Tonkin, Ume-Kulsoom Shah, Shareen H. Doak, M. R. Brown, Katherine E. Chapman, George E. Johnson, Eleanor C. Wilde, Gareth J.S. Jenkins, Jatin R Verma
Publikováno v:
Mutagenesis. 35:445-452
In vitro genotoxicity studies are a quick and high throughput approach to assess the genotoxic potential of chemicals; however, the reliability of these tests and their relevance to in vivo effects depends on the choice of representative cell line an
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b755356f16ce5a2d98c3ba5d94c14241
https://doi.org/10.1093/mutage/geaa029
https://doi.org/10.1093/mutage/geaa029
Autor:
Samantha V. Llewellyn, Ali Kermanizadeh, Victor Ude, Nicklas Raun Jacobsen, Gillian E. Conway, Ume-Kulsoom Shah, Marije Niemeijer, Martijn J. Moné, Bob van de Water, Shambhu Roy, Wolfgang Moritz, Vicki Stone, Gareth J.S. Jenkins, Shareen H. Doak
Publikováno v:
Toxicology in Vitro
Toxicology In Vitro, 85, 105473
Toxicology In Vitro, 85, 105473
To reduce, replace, and refine in vivo testing, there is increasing emphasis on the development of more physiologically relevant in vitro test systems to improve the reliability of non-animal-based methods for hazard assessment. When developing new a
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3280abd30bca97acfa6499c0f19f06ed
https://cronfa.swan.ac.uk/Record/cronfa61299
https://cronfa.swan.ac.uk/Record/cronfa61299
Autor:
Ann T. Doherty, George E. Johnson, Fiona M. Chapman, Katherine E. Chapman, Jatin R. Verma, Eleanor C. Wilde, James A. Tonkin, Leanne M. Stannard, Gareth J.S. Jenkins, M. Rowan Brown, Ume-Kulsoom Shah, Anna L. Seager, Shareen H. Doak
Publikováno v:
Archives of Toxicology
Current in vitro genotoxicity tests can produce misleading positive results, indicating an inability to effectively predict a compound’s subsequent carcinogenic potential in vivo. Such oversensitivity can incur unnecessary in vivo tests to further
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::57a23b0c49eed7468aa74bcdecf69813
https://cronfa.swan.ac.uk/Record/cronfa55186/Download/55186__18359__b5f156f08e5d4ed9bbdcc8a37f5027bb.pdf
https://cronfa.swan.ac.uk/Record/cronfa55186/Download/55186__18359__b5f156f08e5d4ed9bbdcc8a37f5027bb.pdf
Advanced 3D Liver Models for In vitro Genotoxicity Testing Following Long-Term Nanomaterial Exposure
Autor:
Gillian E. Conway, Gareth J.S. Jenkins, Samantha V. Llewellyn, Stephen J. Evans, Martin J. D. Clift, Ume-Kulsoom Shah, Shareen H. Doak
Publikováno v:
Journal of Visualized Experiments
Due to the rapid development and implementation of a diverse array of engineered nanomaterials (ENM), exposure to ENM is inevitable and the development of robust, predictive in vitro test systems is essential. Hepatic toxicology is key when consideri
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7a85ca4f231f559e96156fd1169ea39f
https://doi.org/10.3791/61141-v
https://doi.org/10.3791/61141-v
Autor:
Ume-Kulsoom Shah, Gareth J.S. Jenkins, Katherine E. Chapman, Neenu Singh, Shareen H. Doak, Jefferson de Oliveira Mallia
Publikováno v:
Mutation Research/Genetic Toxicology and Environmental Mutagenesis. 834:35-41
The file attached to this record is the author's final peer reviewed version. The Publisher's final version can be found by following the DOI link. The liver's role in metabolism of chemicals makes it an appropriate tissue for toxicity testing. Curre
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::498a76c6d217ba0ca7b54e0d5d12c4d6
https://doi.org/10.1016/j.mrgentox.2018.06.020
https://doi.org/10.1016/j.mrgentox.2018.06.020
Autor:
Neenu Singh, Gareth J.S. Jenkins, Ume-Kulsoom Shah, Shareen H. Doak, Jefferson de Oliveira Mallia, Katherine E. Chapman
Publikováno v:
Mutation Research/Genetic Toxicology and Environmental Mutagenesis. 825:51-58
The liver’s role in metabolism of chemicals makes it an appropriate tissue for toxicity testing. Current testing protocols, such as animal testing and two-dimensional liver cell systems, offer limited resemblance to in vivo liver cell behaviour, in
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::32850b3e561b5dd20f9da345d28c9394
https://doi.org/10.1016/j.mrgentox.2017.12.005
https://doi.org/10.1016/j.mrgentox.2017.12.005