Zobrazeno 1 - 10
of 90
pro vyhledávání: '"Umbrella trial"'
Autor:
Paul Hutton, James Kelly, Christopher D. J. Taylor, Brian Williams, Richard Emsley, Candy Ho Alexander, Anvita Vikram, David Saddington, Andrea McCann, Joseph Burke, Emma Eliasson, Sean Harper, Thanos Karatzias, Peter J. Taylor, Andrew Watson, Nadine Dougall, Jill Stavert, Suzanne O’Rourke, Angela Glasgow, Regina Murphy, Karen Palmer, Nosheen Zaidi, Polly Bidwell, Jemma Pritchard, Lucy Carr, Amanda Woodrow
Publikováno v:
Pilot and Feasibility Studies, Vol 9, Iss 1, Pp 1-17 (2023)
Abstract Background A high proportion of patients diagnosed with schizophrenia-spectrum disorders will at some point in their lives be assessed as not having the capacity to make their own decisions about pharmacological treatment or inpatient care (
Externí odkaz:
https://doaj.org/article/a8b6f3b9fd824d0c8ff7556c480011ad
Autor:
张怡君, 田雪, 胥芹, 张晓丽, 王安心
Publikováno v:
Zhongguo cuzhong zazhi, Vol 18, Iss 2, Pp 240-243 (2023)
近年来，主方案设计已被广泛应用于临床试验中。主方案设计可以在多种疾病中评估一种或多种干预措施的疗效，也可以在单一疾病中评估多种干预措施的疗效。篮式研究和伞式研究是主方
Externí odkaz:
https://doaj.org/article/187fde77563448ea83e02ded4468857c
Autor:
Karolina Strzebonska, Mateusz Blukacz, Mateusz T. Wasylewski, Maciej Polak, Bishal Gyawali, Marcin Waligora
Publikováno v:
BMC Medicine, Vol 20, Iss 1, Pp 1-16 (2022)
Abstract Background Umbrella clinical trials in precision oncology are designed to tailor therapies to the specific genetic changes within a tumor. Little is known about the risk/benefit ratio for umbrella clinical trials. The aim of our systematic r
Externí odkaz:
https://doaj.org/article/fde121abb1274be4bdfa675f15665d8f
Autor:
Louise C Brown, David Fisher, Richard Adams, Jenny Seligmann, Matthew Seymour, Richard Kaplan, Susan D Richman, Philip Quirke, Rachel Butler, Helen Roberts, Janet Graham, Richard H Wilson, Timothy S Maughan
Publikováno v:
Efficacy and Mechanism Evaluation, Vol 9, Iss 9 (2022)
Background: Complex trials with innovative designs are becoming increasingly common and offer the potential to improve patient outcomes in a shorter time frame. There is evidence that patients with colorectal cancer fall into different subgroups with
Externí odkaz:
https://doaj.org/article/a710ce8c7ebb4534b2145ccccfea160e
Akademický článek
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Autor:
Yuan B
Publikováno v:
Pharmacogenomics and Personalized Medicine, Vol Volume 14, Pp 487-496 (2021)
Bing Yuan HK Modern Chinese Medicine R&D Center, Hong KongCorrespondence: Bing YuanHK Modern Chinese Medicine R&D Center, Room 2, 7/F Kiu Kin Mansion, 566-568 Nathan Road, Kowloon, Hong KongEmail greenisland@vip.163.comAbstract: The rise of precision
Externí odkaz:
https://doaj.org/article/f625af6671d046a4be75e63917cce10c
Autor:
Florian Lüke, Dennis Christoph Harrer, Pan Pantziarka, Tobias Pukrop, Lina Ghibelli, Christopher Gerner, Albrecht Reichle, Daniel Heudobler
Publikováno v:
Frontiers in Oncology, Vol 12 (2022)
The combinatory use of drugs for systemic cancer therapy commonly aims at the direct elimination of tumor cells through induction of apoptosis. An alternative approach becomes the focus of attention if biological changes in tumor tissues following co
Externí odkaz:
https://doaj.org/article/e9cddf90b49d4395930e3c6b358fab04
Autor:
Karolina Strzebonska, Marcin Waligora
Publikováno v:
BMC Medical Ethics, Vol 20, Iss 1, Pp 1-10 (2019)
Abstract Background Novel precision oncology trial designs, such as basket and umbrella trials, are designed to test new anticancer agents in more effective and affordable ways. However, they present some ethical concerns referred to scientific valid
Externí odkaz:
https://doaj.org/article/6fc963a104cc4110a6515ee2c4949d79
Autor:
Young Kyung Ko, Jeong-An Gim
Publikováno v:
Pharmaceutics, Vol 14, Iss 8, p 1539 (2022)
Depending on the patients’ genotype, the same drug may have different efficacies or side effects. With the cost of genomic analysis decreasing and reliability of analysis methods improving, vast amount of genomic information has been made available
Externí odkaz:
https://doaj.org/article/73ed5fac965b4315a48e133c764d691f
Akademický článek
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