[68Ga]Ga-DOTAGA-Glu(FAPi)2 Shows Enhanced Tumor Uptake and Theranostic Potential in Preclinical PET Imaging

Autor: Julie van Krimpen Mortensen, Simona Mattiussi, Lars Hvass, Emilie Graae Lund, Vladimir Shalgunov, Frank Roesch, Umberto Maria Battisti, Matthias Manfred Herth, Andreas Kjaer

Publikováno v: Diagnostics, Vol 14, Iss 18, p 2024 (2024)

The use of fibroblast activation protein inhibitors (FAPis) for positron emission tomography (PET) imaging in cancer has garnered significant interest in recent years, yielding promising results in preclinical and clinical settings. FAP is predominan

Externí odkaz: https://doaj.org/article/0f620831dd6c421fb00297db7f050fe5

Optimization of Direct Aromatic 18F-Labeling of Tetrazines

Autor: Ida Vang Andersen, Rocío García-Vázquez, Umberto Maria Battisti, Matthias M. Herth

Publikováno v: Molecules, Vol 27, Iss 13, p 4022 (2022)

Radiolabeling of tetrazines has gained increasing attention due to their important role in pretargeted imaging or therapy. The most commonly used radionuclide in PET imaging is fluorine-18. For this reason, we have recently developed a method which e

Externí odkaz: https://doaj.org/article/d8cf2e1b9f7e4868bcc9e4e8073b8b37

Synthesis and radiolabeling of a polar [ 125 I]I‐1,2,4,5‐tetrazine

Autor: Natasha Bidesi, Vladimir Shalgunov, Umberto Maria Battisti, Lars Hvass, Jesper Tranekjær Jørgensen, Christian B. M. Poulie, Andreas I. Jensen, Andreas Kjaer, Matthias M. Herth

Publikováno v: Bidesi, N, Shalgunov, V, Battisti, U M, Hvass, L, Jørgensen, J T, Poulie, C B M, Jensen, A I, Kjaer, A & Herth, M M 2023, ' Synthesis and radiolabeling of a polar [ 125 I]I-1,2,4,5-tetrazine ', Journal of Labelled Compounds and Radiopharmaceuticals, vol. 66, no. 1, pp. 22-30 . https://doi.org/10.1002/jlcr.4009

Pretargeting imaging has gained a lot of prominence, due to its excellent bioorthogonality and improved imaging contrast compared to conventional imaging. A new iodo tetrazine (Tz) derivative has been synthesized and further developed into the corres

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e8196a963928bd991c82cecd9b536981
https://doi.org/10.1002/jlcr.4009

Alpha-Synuclein PET Tracer Development—An Overview about Current Efforts

Autor: Špela Korat, Natasha Shalina Rajani Bidesi, Federica Bonanno, Adriana Di Nanni, Anh Nguyên Nhât Hoàng, Kristina Herfert, Andreas Maurer, Umberto Maria Battisti, Gregory David Bowden, David Thonon, Daniëlle Vugts, Albert Dirk Windhorst, Matthias Manfred Herth

Publikováno v: Pharmaceuticals, Vol 14, Iss 9, p 847 (2021)

Neurodegenerative diseases such as Parkinson’s disease (PD) are manifested by inclusion bodies of alpha-synuclein (α-syn) also called α-synucleinopathies. Detection of these inclusions is thus far only possible by histological examination of post

Externí odkaz: https://doaj.org/article/6f08dda7133841da83960bbb97283473

Synthesis and in vivo evaluation of [

Autor: Marius, Müller, Vladimir, Shalgunov, Lars, Hvass, Jesper T, Jørgensen, Vasko, Kramer, Markus, Staudt, Umberto Maria, Battisti, Andreas, Kjaer, Matthias M, Herth

Publikováno v: Bioorganicmedicinal chemistry letters. 80

Tucatinib is a selective human epidermal growth factor receptor 2 (HER2) tyrosine kinase inhibitor approved by the U.S. Food and Drug Administration (FDA) in April 2020 for HER2-positive lesions in metastatic breast cancer patients, including CNS met

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::92ca2c5acc12e5bdaf6a3fddc5c005e3
https://pubmed.ncbi.nlm.nih.gov/36455802