Zobrazeno 1 - 10
of 134
pro vyhledávání: '"Umberto Laforenza"'
Autor:
Pawan Faris, Agnese Rumolo, Giorgia Pellavio, Matteo Tanzi, Mauro Vismara, Roberto Berra-Romani, Andrea Gerbino, Salvatore Corallo, Paolo Pedrazzoli, Umberto Laforenza, Daniela Montagna, Francesco Moccia
Publikováno v:
Cell Death Discovery, Vol 9, Iss 1, Pp 1-10 (2023)
Abstract Colorectal carcinoma (CRC) represents the fourth most common cancer worldwide and is the third most common cause of malignancy-associated mortality. Distant metastases to the liver and lungs are the main drivers of CRC-dependent death. Pro-o
Externí odkaz:
https://doaj.org/article/ec3c7131d39a44beb21ad7dc3b05cf0b
Autor:
Giorgia Pellavio, Maria Paola Demichelis, Patrizia Sommi, Umberto Anselmi-Tamburini, Claudia Scotti, Umberto Laforenza
Publikováno v:
International Journal of Molecular Sciences, Vol 25, Iss 1, p 372 (2023)
Aquaporins (AQPs) allow the diffusion of hydrogen peroxide (H2O2) and act as ROS scavenging systems, which are important for controlling the redox state of cells. Recently, cerium oxide nanoparticles were found to increase the water and H2O2 permeabi
Externí odkaz:
https://doaj.org/article/0851edb3a22e4788844a1d492223772a
Autor:
Giacomo Rossino, Annamaria Marra, Roberta Listro, Marco Peviani, Elena Poggio, Daniela Curti, Giorgia Pellavio, Umberto Laforenza, Giulio Dondio, Dirk Schepmann, Bernhard Wünsch, Martina Bedeschi, Noemi Marino, Anna Tesei, Hee-Jin Ha, Young-Ho Kim, Jihyae Ann, Jeewoo Lee, Pasquale Linciano, Marcello Di Giacomo, Daniela Rossi, Simona Collina
Publikováno v:
Pharmaceuticals, Vol 16, Iss 7, p 962 (2023)
Neuropathic pain (NP) is a chronic condition resulting from damaged pain-signaling pathways. It is a debilitating disorder that affects up to 10% of the world’s population. Although opioid analgesics are effective in reducing pain, they present sev
Externí odkaz:
https://doaj.org/article/35d4e6301ce4448da02e9dbd77693350
Autor:
Roberto Berra-Romani, Ajelet Vargaz-Guadarrama, Josué Sánchez-Gómez, Nayeli Coyotl-Santiago, Efraín Hernández-Arambide, José Everardo Avelino-Cruz, Mario García-Carrasco, Monica Savio, Giorgia Pellavio, Umberto Laforenza, Alfredo Lagunas-Martínez, Francesco Moccia
Publikováno v:
Frontiers in Cell and Developmental Biology, Vol 10 (2022)
Histamine is an inflammatory mediator that can be released from mast cells to induce airway remodeling and cause persistent airflow limitation in asthma. In addition to stimulating airway smooth muscle cell constriction and hyperplasia, histamine pro
Externí odkaz:
https://doaj.org/article/2976a1a97f9f497d8c8b06d19df3de87
Autor:
Roberto Berra-Romani, Valentina Brunetti, Giorgia Pellavio, Teresa Soda, Umberto Laforenza, Giorgia Scarpellino, Francesco Moccia
Publikováno v:
Cells, Vol 12, Iss 13, p 1732 (2023)
Nitric oxide (NO) represents a crucial mediator to regulate cerebral blood flow (CBF) in the human brain both under basal conditions and in response to somatosensory stimulation. An increase in intracellular Ca2+ concentrations ([Ca2+]i) stimulates t
Externí odkaz:
https://doaj.org/article/140defea8571408f955496e07e62e654
Autor:
Giorgia Pellavio, Patrizia Sommi, Umberto Anselmi-Tamburini, Maria Paola DeMichelis, Stefania Coniglio, Umberto Laforenza
Publikováno v:
International Journal of Molecular Sciences, Vol 23, Iss 18, p 10837 (2022)
Some aquaporins (AQPs) allow the diffusion of hydrogen peroxide (H2O2), the most abundant ROS, through the cell membranes. Therefore, the possibility of regulating the AQP-mediated permeability to H2O2, and thus ROS scavenging, appears particularly i
Externí odkaz:
https://doaj.org/article/a34ae24d57364ff58269a1c76d160c30
Publikováno v:
Cells, Vol 11, Iss 12, p 1892 (2022)
Malignant pleural mesothelioma (MPM) is an aggressive cancer of the pleural surface and is associated with previous asbestos exposure. The chemotherapy drug is one of the main treatments, but the median survival ranges from 8 to 14 months from diagno
Externí odkaz:
https://doaj.org/article/e640855aa60a4da2b534f33c63b0ed2e
Autor:
Kamil Gotfryd, Andreia Filipa Mósca, Julie Winkel Missel, Sigurd Friis Truelsen, Kaituo Wang, Mariana Spulber, Simon Krabbe, Claus Hélix-Nielsen, Umberto Laforenza, Graça Soveral, Per Amstrup Pedersen, Pontus Gourdon
Publikováno v:
Nature Communications, Vol 9, Iss 1, Pp 1-11 (2018)
Uptake and release of glycerol from the small intestine and adipocytes is facilitated by a subclass of aquaporins (AQP), but how glycerol flow is regulated remains poorly understood. Here authors solve the crystal structure of AQP10 and show how lipo
Externí odkaz:
https://doaj.org/article/f2f9e79e53f4454685084cc268e265dc
Autor:
Giuseppe Gagliano, Anita Monteverdi, Stefano Casali, Umberto Laforenza, Claudia A. M. Gandini Wheeler-Kingshott, Egidio D’Angelo, Lisa Mapelli
Publikováno v:
Cells, Vol 11, Iss 6, p 1047 (2022)
Neurovascular coupling (NVC) is the process associating local cerebral blood flow (CBF) to neuronal activity (NA). Although NVC provides the basis for the blood oxygen level dependent (BOLD) effect used in functional MRI (fMRI), the relationship betw
Externí odkaz:
https://doaj.org/article/e2d39ce048314253b658c578c836e231
Autor:
Giorgia Pellavio, Giacomo Rossino, Giulia Gastaldi, Daniela Rossi, Pasquale Linciano, Simona Collina, Umberto Laforenza
Publikováno v:
International Journal of Molecular Sciences, Vol 22, Iss 18, p 9790 (2021)
Sigma1 Receptor (S1R) is involved in oxidative stress, since its activation is triggered by oxidative or endoplasmic reticulum stress. Since specific aquaporins (AQP), called peroxiporins, play a relevant role in controlling H2O2 permeability and ens
Externí odkaz:
https://doaj.org/article/944a5086b18240db84d846a95af83d67